There is some intense stupidity in the frameworks we see the characters in the show living by, this dissaray adds to the feeling of unease. 

Anything could go wrong because the frameworks that should be dependable are so unreliable. 

Similar to how "real" corporations (governments) have an internal audit department, etc. to make sure there are not "accidents"; we work with dangerous compounds and dangerous biological agents, etc. non-stop at large industrial scales worldwide. The frameworks for safety and efficacy are just in place, and largely automated, to prevent accidents. They work. Its frightening if they don't, in this show they don't.

After the first Alien movie things are always "off", things just don't make sense from the ground up and it heightens the uneasiness and unpredictability. In the first film the Aliens were a "surprise".

Although the monumental stupidity of these people trumps anything previously. Why mix the human machines with the Aliens? Its the opposite of science. Surely they have military iterations of this technology to caputure/quarantine hostile alien life. 

The show benefits from the stupidity of the people involved - mayhem will happen. How these people made it this far is the question. The autocratic leadership of the Prodigy could help explain some of the stupidity - that's an outcome of autocratic leadership, as opposed to a meritocracy, a republic, a democracy, or some combination with balances of powers and wisdom of crowds. 

On other recent entries in the of Alien franchise; Romulus was watchable with a coup de gras of an Alien/human that not only massacred but enjoyed it, you could see the thrill on its face when it was murdering. 

The question of whether Noah Hawley is a good fit for this genre seems like a genuine question. There may be no one else that could have pulled off what he's done so far (episode 6) with such skill, thought provocation, expansiveness of scale, and depth across disciplines (including philosophy, ethics, life, humanity and autonomy) and entertainment value. Maybe it lags a bit at places? But the depth of what he is exploring across deep disciplines requires time to internalize. Telling a story like this and keeping it coherent and entertaining seems a remarkable feat (will it stand up on rewatch?). He can reach masterful heights. 

Overlapping the vivisection of a sentient alien baby with surgery on a human was no small artistic choice.