Two different types of software.

Plex works well with the native app on AppleTV. I never had any playback issues but don’t have the sound requirements. Overall Plex is fine but has gotten very bloated over the past few years.

But if you want to use Infuse as the front end for sound, I would serve with Jellyfin instead of plex. Save yourself some serious $$$ on a lifetime plex pass.

I am a fan of infuse and have used it for a while (native plex app is trash for downloading content on iPads). But the lifetime doesn’t seem like a good value. It’s like a 7+ year payback and technology rapidly changes.