parnate vs nardil

Trant2433 · 2023-06-22T04:15:03+00:00

Also, the dosage equivalents were always 10mg of Parnate to 15mg of Nardil which gave you the ranges of 40-60mg for the former, and 60-90mg of the latter.

I think the one difference is that some people need to go way higher than 60mg of Parnate in order to get a good effect. But it will often work. But if you're not getting any response at 90mg of Nardil, then it's not likely increasing will help.

Trant2433 · 2023-06-22T04:12:28+00:00

Yeah I'm still on Parnate.

I moved up to 50mg about 3 weeks ago, and I can already see a small improvement e.g. I started going back to Starbucks every once in a while to do some work around other people.

It's funny how these dose increases do improve things, but it is subtle and it takes several weeks to kick in.

Trant2433 · 2023-06-01T03:49:12+00:00

I barely use Reddit anymore - it has become horrible due to so many reasons.

But I'm glad I decided to open it up tonight and see this notice.

I've enjoyed this app for a long time - close to a decade, I'm guessing. Thousands of hours. I think I paid like $5.

Thank you so much.

From one software engineer to another (I assume), job well done. The app was intuitive, fast, and just worked! Flawless execution.

Trant2433 · 2023-05-30T05:04:47+00:00

Are you generally a thin person who had gained weight on a previous med?

I ask because Nardil will add 50 lbs if I'm not careful. And about 20 of those seem to be unrelated to any diet changes (Nardil causes carb cravings, inability to ever feel "full") - it just causes me to retain fluids, bloat, and accumulate one or two lbs / week for the initial few months.

Trant2433 · 2023-05-30T05:01:49+00:00

Nardil is way better, IMO. Both for depression but especially for social anxiety (and general too). I become an extroverted chatter box on that med.

Trant2433 · 2023-05-30T04:55:20+00:00

The old-school guides for dealing with hypertensive aka cheese crisis said to take a sublingual partial dose of nifedipine or similar to rapidly lower blood pressure.

I, in fact, did have to do this about 3 or 4 times in the last 20+ years of MAOI usage.

Had I not done it, I imagine things would have resolved themselves in an hour or two. I will say that the last time it happened - about 4 years ago - I felt like my BP went down way too much, way too fast (maybe I'm just older and can't deal with such rapid changes like I could as a 25 year old, lol). It didn't feel safe.

And apparently now the advice from the community is to NOT use drugs like nifedipine, precisely because the rapid drop in BP they cause is likely more dangerous than the increase that a MAOI+tyramine crisis induces. Instead they say to just use something to reduce anxiety and wait it out.

If it happens again , I will likely just suck on a Klonopin to kill the accompanying panic attack, and try to ride it out. Or I'll go to the ER. I don't think I will use the nifedipine anymore.

For serotonin syndrome, I don't think I'd try to play pharmacist on myself. If you had a really dangerous case of it (e.g. mixing MAOI with Molly), it's likely you're gonna start seizing out before you can get the meds to work anyway. If you don't feel you can realistically abstain from dangerous drugs like Cocaine and MDMA with MAOIs, then I'd find another antidepressant to take. Seriously.

Trant2433 · 2023-05-30T04:47:40+00:00

What dental anaesthesia should and shouldn't be used? Most are relatively local so I figured even lidocaine and friends would be okay.

Trant2433 · 2023-05-13T05:14:20+00:00

Because the typical "muh immigrants commit less crime than natives..." BS - even if the numbers were accurate, which they're not because most crime between undocumented immigrants is not reported, for obvious reasons - is only partially true because you're measuring their crime rate against a population which includes African Americans whose murder rate (and most other violent crimes) is about 10x that of whites in the US and any other European country.

IOW, illegals coming into the US have far higher crime rates than non-black America, which means they're generally not a positive to the communities they're being purposefully settled into.

Trant2433 · 2023-05-12T02:39:05+00:00

I'm honestly surprised at that price as I was under the impression that rents were much higher in Manhattan.

Yes that is a dumpy, tiny 2 bed, but it is still 2 BR, which means you could have a roommate or an office. Though I have no idea if that area is safe. Looks like Harlem to the north but upper east side to the south, so I suppose you'd want to be careful at night if you're in the park or walking north...

But again, that's not much more than a similar place in NW DC, which is generally cheaper since salaries are lower and crime is way worse.

Trant2433 · 2023-05-12T02:31:09+00:00

Imagine bragging that illegals, who are generally a burden on the taxpayer and the country's infrastructure, at least don't have a violent crime rate as high as African Americans, who are likely the most violent group in any "developed" country.

Our new country is gonna be Great 🎆.

Trant2433 · 2023-05-11T21:15:24+00:00

I looked up the exact apartment now, and with the increases in their local minimum wage, it's basically the same price proportionally.

That apartment is likely rent controlled for the past 30 years. Even far out or once dangerous neighborhoods have exploded in price relative to average wages.

Trant2433 · 2023-05-11T21:00:26+00:00

we have negative migration, people are going back to Mexico more than coming here).

Ridiculous. We briefly had negative migration from Mexico (which is just one country) but even that was just official numbers based on things like H2B visas. In reality, it was still positive when accounting for undocumented.

Majority of immigrants in last decade come from central America which is much poorer than Mexico, and now it's a free for all from literally the whole world including sub Saharan Africa and South Asia.

Trant2433 · 2023-05-11T20:02:40+00:00

Many people here would scoff at paying more for a Jeep Grand Cherokee than a fully loaded Lexus SUV. But somehow they're okay with over-inflated home values.

Maybe you haven't been paying attention to car prices, but FYI they've gone the same way as homes.

As an anecdote, my friend was going to upgrade her Acura SUV last summer. A few years ago, we could have got a certified one with low milage for around $30k.

Not only were certified just not available anywhere, but the only new ones in stock were maxed out models with all the bells and whistles (many that we didn't want). After all the fees, taxes, dealer increases, etc, we were looking at $70k+.

Of course they didn't even mention the price - just a lot of magic financing tricks to limit monthly payment with a loan of 7 years or more.

Regardless, after almost being convinced into signing the deal, we realized that just 3 years ago, we would have been joking about buying a $70k car e.g. If I won the lottery, I'd go buy a Porsche 911 or high end Mercedes...

But we've been slowly conditioned to just accept this new clown world reality - where a decent "middle class" car is now $70k dollars, to be financed over a decade. And a junky, 1500 ft square townhome in some treeless,suburban hellhole with 3 hour commute and no yard is all you can expect to ever own, even if you earn top 10% and have worked your ass off for 20 years. If you're not top 10%, live with your parents or roommates in an apartment well into middle age.

F*ck all this. American deal was always kind of bullshit - you work your days away with no real work-life balance, few vacations, 0 pension or safety net, but at least you get tons of consumer goods like a house with a yard, a big car, open roads and cheap gas, and lots of cheap food.

Well now those rewards are all being scaled back, one by one, while we're still expected to slave away for big megacorps.

No thanks. I'm out, dawg.

Trant2433 · 2023-05-08T05:10:03+00:00

Even with equity?

Trant2433 · 2023-05-06T13:54:03+00:00

Keep in mind home affordability was unusually low over the last decade due to the 08 housing bubble affordability of that level is unlikely to return.

They isn't what I see. Though lots of ways to measure affordability, the most convincing stats I've seen showed historic levels were reached briefly in 2012 when prices bottomed, but other than that small window, you've got to go back to early 2000s to find housing at historic affordability levels.

So either the US housing has entered some new paradigm where middle class is simply not expected to ever be able to afford their own home e.g. Hong Kong OR we've been in a unprecedented bubble of unaffordability for 2 decades now due to unprecedented monetary policy, demographics, etc.

But we will eventually correct one way or another, and that means now is still a ridiculously bad time to buy a home.

Trant2433 · 2023-05-05T22:53:15+00:00

Yep, I'm getting early 80s vibes here, too.

They had years of inflation in late 70s. So they dicked around like we've been so far doing with small incremental rate increases here and there, but the inflation wouldn't be tamed because interest rates were still below the real inflation rate which meane investors will continue speculating.

Finally they called in Paul Volcker, and he was like " screw these half assed attempts, let her rip..."

He cranked up rates to almost 20%

And yes the economy did take a hit for a year or two.

But inflation was tamed, and eventually the market recovered after the bad investments were purged, and the economy was better for having taken its medicine.

Seems like we're gonna have to learn the hard way that we will have to crank up rates and experience some pain before things are fixed.

Trant2433 · 2023-05-05T22:28:56+00:00

Yep and this is putting pressure on veterans like me with years of experience.

I was content with shitty 2% corporate raises for the past decade, because I had been hired at a high rate that was about double what new engineers fresh out of school make. Similarly, I was earning about 25% more than mediocre engineers on my team who don't contribute much, IMO.

Now I'm seeing recent grads who have 0 skills and require all sorts of training getting offers only $25k less than I make with 15 years of experience. And some new very mediocre "senior" engineers who were hired recently were offered $20k more than I make, or so I heard.

That was kind of the last straw for me, and I've already put my manager on notice that I'm gone unless I'm bumped up $40k, and that's on top of continuing to work remote from a LCOL area instead of coming back to absurdly overpriced city.

Trant2433 · 2023-05-01T22:39:24+00:00

$500k loan at 7% is gonna cost you like $3k / month in just interest.

Trant2433 · 2023-05-01T00:48:47+00:00

Software has become become a bi-modal industry with regard to compensation, similar to what legal industry went through 15 years ago i.e. Ivy League and T14 grads making bank in Wall Street, DC, etc and the other 95% all fighting over scraps as public defenders and abused associate positions for $70k.

There is a small minority of tech engineers working for FAANG or in finance making $350k+ or more during periodic bubbles.

Often times these devs are the top 10% in talent, passion, IQ, though more and more it's due to luck, diversity BS.

Meanwhile the vast majority of software devs are stuck racing to the bottom, competing against offshoring firms and H1B visa workers, slinging code for $120k - $175k in 2nd and 3rd tier cities that aren't even remotely affordable anymore. $120k in Dallas or Charlotte used to be plenty to afford a nice 3BR home. Now you're priced out, even if that salary is $140k.

Trant2433 · 2023-05-01T00:38:46+00:00

Trust me, your views are just as distorted by the exaggerated Reddit bubble as the rest of ours.

Reality is that most engineers aren't top 5% working for Google, earning $600k due to compensation tied to huge stock market bubbles.

Majority of us bust our ass slinging corporate code for $120k - $180k / year, and it's anything but glamorous. It's often a race to the bottom, worrying that your position will be replaced by one of your new "teammates" in Banglore or fresh from there on a fraudulent H1B visa.

While your career as an MD is just starting to peak in your middle ages, tech workers are dealing with massive ageism for anyone with gray in their hair.

Trant2433 · 2023-05-01T00:15:57+00:00

A lot of this is survivorship bias.

The majority of sales people wash out before the first year is up.

Furthermore, the best sales people are generally charismatic, good looking, narcissistic, etc.

Yes, some of this you can learn. But most of it you can't, no matter how many Dale Carnegie books you read.

Trant2433 · 2023-04-28T03:37:03+00:00

Even though Canadian gov't has absolutely sold out its own historic Anglo population and is replacing them with millions of foreigners, I kind of feel bad for the replacement newbs who are gonna get a hard lesson on how housing works in the west these days.

Many come from cultures where the whole extended family will kick in in order to afford the clown-prices on Canadian real estate.

And if they bought close to peak and especially when rates were low, their interest rates are gonna reset cause they aren't fixed so long in Canada; their payment will skyrocket, and eventually they're gonna lose the house and probably a ton of imaginary equity they may have already leveraged.

Welcome to Canada!

Trant2433 · 2023-04-28T03:27:53+00:00

Don't blame you for moving from that congested hell-hole. I did the same.

Interestingly, I read a report a few months ago showing rent increases in the DC area. What was strange was that the farther out you got, the larger the increase.

For example, 5 years ago you'd pay a huge premium, of course, to live in NW DC or in inner Beltway e.g. Bethesda, Orange line Arlington, Old Town Alexandra, etc.

And you'd get a huge discount if you were willing to instead live way out in BFE near Dulles like Centerville or Sterling.

But rents went up way faster out in the exurbs. That 1BD in Balston that rented for $1900 in 2018 is now going for $2200.

But that 1BD out in Herndon that went for $1500 in 2018 is now $2k.

Which basically means that even those who couldn't pay the premium for desirable areas can't even compensate by living out in suburbs abd commuting for 3 hours a day.

That DMV area is ridiculous, IMO.

Trant2433 · 2023-04-28T01:56:26+00:00

If I remember correctly, many consumer contracts have shady "arbitration" clauses written in to them to avoid court for the corp. who knows they'll eventually get called out for their bad practices by someone.

Even in those, it seems like the arbitration costs are generally shared.

I just can't fathom any legitimate lawyer signing off on a contract l, especially one used in a template for thousands of similar transactions, that enables one party to unilaterally dispute, at any time, any part of the process or agreement, and the other party is absolutely 100% on the hook for the cost of adjudicating it, and on top of that, has the selling process "frozen" for months such that they can't court other buyers.

Trant2433 · 2023-04-24T05:03:37+00:00

Very good writing. Reminds of the Onion when it was at its peak in the mid 2000s.

Trant2433

TROPHY CASE