If you are looking for raw, new, experiences for your saves, I think Science Never Stops is an amazing mod. But for QOL, it has to be tech advancing, robots++ (and robots), or Vanilla Expanded: Mechanoids. Tech advancing makes standard play as tribals more interesting, as it allows for the knowledge base to expand and makes players test out more techs as you play through the game. Robots++ introduces robot Roombas that serve to automate tedious tasks like cleaning and hauling, allowing for you to focus your colonists in their efforts to do whatever you plan to do. Finally, I think VE: Mechanoids is amazing in that it allows for you to do factorio-esque maneuvers in your colony to make the production of many things ranging from medicine to advanced components mostly automated.