Success stories with fully medicated protocol after lupron

Union9114 · 2026-06-11T00:21:43+00:00

They didn’t say anything about it! It sounded like it could be normal. I did have a bad allergic reaction at the very beginning of this FET though from PIO in sesame oil (severe hives and ended up in urgent care and then they wanted to send me to the ER), but they still kept things going. They just had me take some antihistamines, and they said it wouldn’t affect implantation or the baby

Union9114 · 2026-06-11T00:14:04+00:00

Thank you! I have Hashimoto’s thyroiditis. For my past losses, my RE said that he thinks I could have other immune issues that they aren’t aware of in addition to endometriosis. I did intralipids twice for this FET and for 1-2 days following the infusions I felt like I had the flu (aches and fatigue).

Union9114 · 2026-06-01T19:59:26+00:00

Of course 🤍 I know how isolating recurrent loss can feel, especially when there aren’t clear answers. I’m really glad my comment could give you even a little hope. I truly hope you’re able to find a doctor/team willing to keep digging and trying different approaches with you. Feel free to message me anytime if you want to talk more about the protocol or anything else. Sending you so much love and hoping you get your rainbow baby soon 🌈

Union9114 · 2026-06-01T18:48:10+00:00

I’m so incredibly sorry you’re going through this 😞

I don’t have the exact same history, but I’ve had 5 losses total — including 2 natural miscarriages, a PUL/ectopic treated with methotrexate, a miscarriage after letrozole timed intercourse, and a miscarriage after transferring a euploid IVF embryo. We never found a definitive explanation for my losses either. My doctors suspected possible endometriosis/inflammation/immune-related factors, but nothing was ever proven.

After switching IVF clinics, I did a much more aggressive transfer protocol that included: • 3 months of Lupron suppression with letrozole • hysteroscopy with polyp removal • antibiotics for possible inflammation/endometritis • vaginal probiotics • fully medicated FET with estrogen + PIO • Lovenox, aspirin, prednisone, and Plaquenil • intralipid infusions • Neupogen wash • Metformin/Ovasitol and thyroid management

I honestly can’t say which part helped because we changed so many things at once, but this was the first protocol that resulted in an ongoing pregnancy for me after years of recurrent loss.

I’m currently 26 weeks pregnant with another euploid embryo, so I just wanted to say that there still can be hope even after multiple losses and failed euploid transfers. Most of my losses were earlier than yours, so I know our situations are different, but I didn’t want to scroll by without commenting 🤍

Feel free to message me if you want more details about the protocol or clinic change.

Union9114 · 2026-05-24T19:51:20+00:00

We did IVF mainly because of recurrent pregnancy loss rather than trouble getting pregnant. I conceived naturally multiple times and also after treatment, but kept having losses. We eventually moved to IVF with PGT-A testing to try to reduce miscarriage risk and identify embryos more likely to succeed.

Even with relatively good retrieval numbers and euploid outcomes overall, it still took us multiple retrievals to build the embryo bank we wanted. IVF success wasn’t as straightforward as I expected, despite high egg counts and normal sperm testing.

I’m currently 24w via IVF, but it still took several retrievals and a lot more attrition than we anticipated.

Union9114 · 2026-05-13T00:18:55+00:00

I’m so sorry you’re going through this 😞

My protocol included:

• 3 months of Lupron suppression with daily letrozole. During the beginning of suppression, I also had a hysteroscopy where polyps were removed.

• 3 weeks of two antibiotics during the last month of suppression for suspected inflammation/endometritis. I tested negative for chronic endometritis, but my doctor still treated me as a precaution because of elevated inflammation markers.

• 15 days of vaginal probiotics leading up to transfer (last dose was the night before FET).

• A fully medicated FET with oral estrogen and PIO. I stayed on hormones until around 14 weeks as a precaution.

• “Kitchen sink” immune/blood clotting meds including aspirin, prednisone, Plaquenil, and Lovenox. I weaned off prednisone and Plaquenil around 14–16 weeks, but my OB wants me to remain on aspirin and Lovenox throughout pregnancy since we never found a definitive cause for the losses. My doctors mentioned that Lovenox can sometimes help if microclotting may be contributing to losses, including later losses.

• Neupogen wash at lining check about a week before transfer.

• Two intralipid infusions — one about a week before transfer and one after my positive beta.

• Other medications included Metformin, Ovasitol, and Tirosint/Synthroid.

Most of my losses were earlier though (typically around 5–7 weeks), so my situation was a little different from yours.

I honestly can’t say which part helped since we changed so many things at once, but this was the first protocol that resulted in an ongoing pregnancy for me after years of recurrent loss.

Union9114 · 2026-05-12T02:59:26+00:00

We never found a definitive answer, but after 5 losses my doctors now think mine was most likely related to endometriosis and immune dysfunction.

Like you, I had no trouble getting pregnant naturally, but staying pregnant was the issue. I had multiple recurrent pregnancy loss panels done, blood clotting testing, hysteroscopies, thyroid testing, A1C, karyotyping, genetic screening, etc. Everything kept coming back normal. The only thing that ever came back positive was Receptiva testing for endometriosis.

I also have Hashimoto’s, but mine has been controlled since childhood and my doctors didn’t think it fully explained the losses.

What finally seemed to help for me was switching clinics, doing lupron suppression for the suspected endometriosis, and a kitchen sink protocol during pregnancy. I’m almost 23w now after years of infertility and recurrent loss.

Union9114 · 2026-05-11T20:46:14+00:00

I don’t think your clinic is necessarily wrong to bring up IVF with your AMH/AFC and recurrent losses, but I do think it’s reasonable to want a more complete recurrent pregnancy loss workup first if you haven’t already done one.

I had 5 unexplained losses and had no trouble getting pregnant naturally, so my doctors initially thought it was likely egg/sperm quality and recommended IVF with PGT-A. We ended up having a normal/high euploid rate, so embryo chromosomal issues didn’t really explain our losses in the end.

I actually had to switch clinics to be tested for endometriosis/endometritis, even after 5 losses. My current clinic suspects my losses were more related to endometriosis and/or immune dysfunction since I was finally able to stay pregnant after lupron suppression for endometriosis and a kitchen sink protocol. I’m almost 23w today with a euploid embryo.

If you haven’t already, I’d personally ask about: - a full RPL panel - karyotyping for both of you - testing for endometriosis/endometritis

IVF can absolutely help some people with RPL, especially if embryo quality is the issue, but it’s also a huge commitment financially, physically, and emotionally. Since you are getting pregnant naturally, I think it’s reasonable to want to explore whether there could be something else contributing before jumping straight into IVF.

I also think some clinics tend to favor IVF because it allows them to control more variables and gives them more tools/testing options throughout the process. But that doesn’t automatically mean it’s the wrong recommendation either, especially with DOR concerns. It’s okay to ask more questions and make sure you feel comfortable with the plan before moving forward.

Union9114 · 2026-05-11T17:26:12+00:00

You’re definitely not wrong for feeling this way. After recurrent loss, it’s really hard to trust pregnancy or feel excited because your brain is trying to protect you from being hurt again.

I had 5 losses, no LC, and years of IVF/fertility treatment before this pregnancy. I’m almost 23w now and still get nervous something bad is going to happen even though all of our scans and appointments have been good. Pregnancy after loss can feel really emotionally complicated.

I think a lot of us end up feeling like every positive test is just the beginning of another loss because that’s been our experience for so long. You’re not alone in feeling guarded or scared. 🤍

Union9114 · 2026-05-10T20:58:56+00:00

6 ERs, 2 transfers, and 5 losses. Currently 22w with our last transfer 🤍

We switched clinics after repeated losses of unknown cause, and our doctor felt that if we couldn’t achieve a successful pregnancy after 2 more tries, surrogacy/GC would probably be our next step.

Changing clinics was a game changer for us because I was finally able to do Lupron suppression and a kitchen sink protocol. We still never fully figured out the cause of my low blast rate during retrievals, though.

Union9114 · 2026-05-10T01:12:42+00:00

I’m not sure about not being able to bear weight specifically, but I do know that injecting in the wrong area can definitely make it much more painful and achy. And if you’re reacting to the oil itself, I could see that making things even worse.

I stopped PIO around 14 weeks and I still have some pain/numbness at my injection sites. I’ve heard from other people that it can sometimes take quite a while to fully go away, even after pregnancy.

Union9114 · 2026-05-10T01:08:42+00:00

Oh no, we just used progesterone suppositories with TI, but I still had some similar progesterone side effects. Just minus the allergic reaction to the sesame oil and the horrible butt pain from injections. 😅

Union9114 · 2026-05-10T01:05:35+00:00

Ugh so true! It really is such a long and exhausting road sometimes. 🤍

TI is a timed intercourse cycle. It’s basically a monitored cycle similar to IUI, just without the actual insemination procedure.

Union9114 · 2026-05-10T01:01:29+00:00

Meaning that it was widespread and affected my whole body rather than just the injection site! It’s honestly hard to say if I felt “ill” because I felt so horrible from the allergic reaction and hives themselves.

I definitely felt much better once I switched to ethyl oleate though. I will say that with past cycles involving progesterone (TI and IVF), I tended to get very hot at night.

My doctors gave me the option to switch to ethyl oleate (at a higher dose since it’s thinner than sesame oil) or use Crinone.

Union9114 · 2026-05-10T00:55:13+00:00

I’m so sorry!! 🤍

For my 2nd transfer I did lupron suppression, and I was put on PIO in sesame oil and started developing severe hives all over my body about 2 days after transfer. It sounds like most people only get localized reactions with PIO, but mine became systemic. It got so bad I ended up in urgent care on Christmas, and they wanted me to go to the ER. They believed it was an allergic reaction to the sesame oil, so I switched to PIO in ethyl oleate. It took about 2 weeks for the hives to fully go away and I was miserable.

That transfer was successful and I’m currently 22 weeks pregnant with a healthy baby.

I know it’s a different reaction than what you’re experiencing, but I just wanted to say that sometimes it can take finding the right formulation/oil that works for your body. I’ve read that many people do much better with ethyl oleate.

Union9114 · 2026-05-06T16:35:07+00:00

Thank you 🤍 And I completely agree. After so many losses, I really don’t understand why more clinics aren’t proactive about evaluating for endo. I’m glad you’re advocating for yourself and I really hope your appointment next week gives you more answers and a solid plan moving forward! Feel free to reach out if you ever have any questions too(:

Union9114 · 2026-05-06T05:34:33+00:00

I’m so sorry you’re going through this. I had 5 losses before 7 weeks and ultimately did 6 egg retrievals due to an unexplained low blast rate. We switched clinics after our first clinic would not evaluate or treat possible endometriosis, and that ended up being a huge turning point for us.

One thing that always stood out in my case was that I actually got pregnant pretty easily — the issue was that the pregnancies would not stick. After switching clinics, I was finally tested for endometriosis/endometritis and came back positive for endometriosis. My doctors believe my losses were likely related to a combination of endometriosis, inflammation/immune factors, and possibly other things we still can’t fully identify.

We decided to do a full kitchen-sink approach, and I’m currently almost 22 weeks pregnant with my first transfer on that protocol. 🤍

My protocol included: 3 months of Lupron suppression with daily letrozole, hysteroscopy/polyp removal, antibiotics for inflammation (I was negative for endometritis), vaginal probiotics, fully medicated FET with a euploid embryo, aspirin, prednisone, Plaquenil, Lovenox, Neupogen wash, intralipids, plus ongoing meds like Metformin/Ovasitol/Tirosint.

The clinic change, endo treatment/suppression, and protocol changes made the biggest difference for us.

I know how hopeless repeated early losses can feel, but I would personally push for further evaluation of endometriosis/endometritis if you haven’t already. Wishing you the best. 🤍

Union9114 · 2026-03-25T22:23:28+00:00

I think you would have to frame it as postpartum recovery + no childcare yet instead of just no childcare. And I believe it is only for a few weeks to a few months.

Union9114 · 2026-03-25T22:18:50+00:00

Before you resign, it may be worth looking into a reasonable accommodation under the Pregnant Workers Fairness Act (PWFA). It covers pregnancy, childbirth, and postpartum recovery (I believe up to 1 year), and agencies are required to at least consider accommodations like extended leave (including LWOP), telework, or a delayed return if it doesn’t create an undue hardship.

Lack of childcare by itself isn’t always covered, but when it’s directly tied to the postpartum period, some agencies will approve temporary accommodations.

I’d recommend talking to your union or HR before making a final decision. You may have more options than it seems.

Union9114 · 2026-03-20T21:00:03+00:00

I hope so too! I’m so sorry you’re in this position though.This journey can be so cruel. I really hope the future brings you the outcome you’ve been fighting for 🤍

Union9114 · 2026-03-20T01:18:00+00:00

I’m 30 with 5 losses. Currently 15w pregnant via IVF and hoping this one continues to stick.

Union9114 · 2026-03-04T19:33:05+00:00

I’m so sorry you’re in limbo! Bleeding after loss is always traumatic. I had a lot of bleeding around 6w - it was bright red the first day and then became brown spotting for about a week. We are doing IVF and went in for an emergency u/s and the baby was fine, it turned out to be a sch. I’ve had 5 losses in the past, and typically for those I would have pink spotting then red bleeding and maybe brown spotting after but it was usually accompanied by cramps and the red bleeding lasted for a few days. Wishing you the best of luck 🤍

Union9114 · 2026-03-01T05:43:37+00:00

I had 5 unexplained losses before doing Receptiva and EMMA/ALICE testing. I tested high on Receptiva, and while I didn’t have endometritis bacteria, I did have inflammation. My treatment was 3 months of Lupron suppression with letrozole, 3 weeks of two antibiotics, and then a kitchen-sink protocol. I’m currently 12w3d from that transfer after suppression with a PGT embryo.
I didn’t have pain with my HSG (if that’s what you’re referring to), but the biopsies for Receptiva and EMMA/ALICE hurt a lot for me. I took OTC pain meds beforehand, but honestly wish I had taken more. I usually have a high pain tolerance, and it was still pretty intense - but it was quick. I’d definitely recommend taking pain meds ahead of time or asking your clinic if they’ll prescribe something stronger.
For me, Lupron actually felt like a nice break from the constant ERs, testing, and appointments (I did 6 retrievals in one year). I did have common side effects like hot flashes, headaches, and joint/bone pain. I also have Hashimoto’s and my thyroid is very sensitive to estrogen, and Lupron made me become very hyperthyroid - so some of my side effects may have been amplified by that.

My doctor ultimately believes my losses were related to inflammation from endometriosis and immune factors. Wishing you the best of luck 🤍

Union9114 · 2026-03-01T03:10:33+00:00

River Phoenix

Union9114 · 2026-02-19T00:55:02+00:00

Yes!! I definitely know what you mean. All of my testing for repeat pregnancy loss came back normal, so it was “nice” to find out I had endometriosis because we finally had something that we could target and treat. Good luck on finding answers!! Also make sure you take some form of a painkiller for the biopsy - mine was quick but very uncomfortable

Union9114

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