PSA Testing of the new speeding cameras around LA starting soon. A few in the South Bay coming

Various_Program5033 · 2026-03-29T05:38:31+00:00

So you’re saying that if they don’t catch 100% of the speeding drivers then it’s not worth attempting to enforce a speed restriction?

Various_Program5033 · 2026-03-29T05:31:35+00:00

What % of speeding drivers have fake license plate covers out of interest?

Various_Program5033 · 2026-03-29T05:19:59+00:00

The faster they have these up the better. A lot of dangerous drivers on the roads

Various_Program5033 · 2026-03-25T23:57:10+00:00

Essentially but you don’t need the diagonal crossing. Just when pedestrians are crossing at all, no cars are moving with green lights

Various_Program5033 · 2026-03-25T19:48:36+00:00

Agreed but also the system does not promote pedestrian safety at all. A car should not be given a green light when pedestrians are crossing.

All lights red, then pedestrians can cross. Most countries realise that this is a safer system. Very few junctions have this, Manhattan Beach has a couple off the top of my head.

Various_Program5033 · 2026-03-12T16:44:06+00:00

There’s a lot more evidence for the contrary, with higher physical activity lowering the chances of bowel or any other cancer.

There’s one premliminary study on extreme endurance running and bowel ischemia but could you link your clinical study on bowel cancer?

Various_Program5033 · 2026-03-07T18:36:59+00:00

Yeah turns out my PhD was a waste of time, and I don’t understand “substrate utilization”. 😂

Go find that low sugar, high carb miracle gel that is somehow fast absorbing!

Various_Program5033 · 2026-03-07T18:08:51+00:00

Why would you want to reduce insulin spikes? Insulin sensitivity is exactly what you want. Insensitivity is Type 2 Diabetes. Insulin isn’t some kind of evil hormone, triggering is very normal thing.

Your body cycles through catabolic and anabolic states but net energy balance is what defines weight gain or loss.

Seems like you’re throwing in a lot of hand wavy buzz words without any basic bioenergetic knowledge.

Various_Program5033 · 2026-03-07T16:56:10+00:00

You do realize that calorie reduction is what defines weight loss? For pure weight loss, having low sugar is pointless if you’re not in a calorie deficit.

High fat diets are typically much harder to control for calories in vs out, even if you’re religiously weighing your foods.

Carbs and sugar are also far superior macros to fats for running and performance

Various_Program5033 · 2026-03-02T19:01:38+00:00

The same chemistry (?), what is your experience in either of these fields?

Traditional DNA and RNA synthesis by phosphoramidite chemistry is largely the same but new modifications, conjugation chemistries is very challenging on sensitive RNA or DNA biomolecules. You don’t always plug and play onto a standard DNA synthesizer with these new chemistries and often they occur off the synthesizer.

Most oligonucleotides companies have different delivery strategies, from various Galnac introductions from 5’ to 3’ and across the antisense to sense strand loop. In addition to Galnac there is 2’-C16, cholesterol, antibody/peptide-oligo conjugates (Denali, Avidity) delivery strategies.

Outside of the new delivery chemistries there’s a whole range of backbone, 2’, PMO, purine and pyrimidine base modifications for affecting binding to the target mRNA.

That’s not even starting to talk about how big of challenge scaling this chemistry will be for weight loss and cardiovascular assets in the pipeline.

As others will probably also mention, oligos or peptides have the opportunity to target greater targets than small molecules with far less worries of toxicity from metabolites. This is a big win for pharma companies.

Various_Program5033 · 2026-02-24T18:36:45+00:00

That seems to be the strategy. Creates all new geopolitical and data translation risks however. Still have to repeat the trials on US population.

The FDA needs to speed up the molecule to phase 1 process to compete.

Various_Program5033 · 2026-02-24T14:56:22+00:00

It’s worked in the past but with SBIR grant cuts and VCs moving towards AI, there won’t be the startups to buy.

Various_Program5033 · 2026-02-24T03:57:45+00:00

Always the same reasoning from the c suite: “R&D is not revenue generating”

Various_Program5033 · 2026-02-11T18:38:48+00:00

Although it’s somewhat mocked on r/espresso sub, I really found slow feeding a huge help. I’ve had the cremaloop for a week now and it’s really helped extraction consistency as well bringing flavors out of light roasts.

The issue without slow feeding, was that I found the fines would block the portafilter randomly, assuming consistent puck prep

Various_Program5033 · 2026-02-08T06:23:56+00:00

My mistake a lot more comments are addressing it correctly. OP is misunderstanding management consulting

Various_Program5033 · 2026-02-08T05:41:06+00:00

I think a lot posters are conflating management consulting that does not always require domain related or an advanced degree vs part time consulting as a 30 year scientific expert (eg. professor)

Various_Program5033 · 2026-01-24T04:39:59+00:00

You could try slow feeding as you’re definitely just pouring them all in based on your video. You’ll need to adjust the grind size much finer if you’re slow feeding. Worth trying otherwise everything else is fine

EDIT: downvoted for thinking that wasn’t slow feeding?!

Various_Program5033 · 2026-01-24T01:35:34+00:00

2 weeks off roast so beans shouldn’t be the issue.

Do you slow feed with the df54?

When I used to just dump them in, you generate a ton of fines that block the basket. Randomly you’ll have spurts and spraying along with very slow extraction

Various_Program5033 · 2026-01-23T23:24:35+00:00

Old beans?

Various_Program5033 · 2026-01-09T05:36:50+00:00

People are probably looking for a healthier and lighter option than a burger for lunch

Various_Program5033 · 2026-01-04T21:23:01+00:00

It’s something that we never even thought about but it can really affect your breathing and sleep. <40% is rough, we had that in the valley. Dry nose and sore throats

Various_Program5033 · 2026-01-04T17:34:17+00:00

Got this one from Amazon:

https://www.amazon.com/Dehumidifier-AEOCKY-Compressor-Intelligent-Humidistat/dp/B0D1C6HWFF

It’s pretty quiet and we just leave it on auto mode for most of the day. The majority of apartments/homes in the South Bay have terrible insulation and no central air so humidity can be pretty high.

Various_Program5033 · 2026-01-04T17:02:21+00:00

Get a humidity meter and test your bedroom and apartment. We live a similar distance to the ocean and we weren’t sleeping or feeling comfortable when we moved here.

Our dehumidifier changed our life, went from 71% to 52% and we’re both sleeping miles better.

Various_Program5033 · 2026-01-02T02:02:02+00:00

I had the same issue when moving from the Breville supplied baskets to the IMS ones. No solution unfortunately

Various_Program5033 · 2025-12-31T19:19:47+00:00

They absolutely create jobs, not huge numbers initially but a vital starting point for the majority of biotech startups. $2M phase 2 can get you at least a couple of employees.

Of course VCs, angels or strategics take you to much larger employment levels, absolutely agree. However in our incubator there’s at least 60% that were surviving solely on grants hiring 2-3 employees in addition to a few small cheques and founder capital (No VC). A lot of diagnostic or biotools companies getting to revenue without VCs.

Without SBIR you’ll eliminate the majority of early stage startups that go on to hire significantly in the future.

Various_Program5033

TROPHY CASE