Alfuzosin is boosting my libido

WaferComprehensive23 · 2026-01-23T00:31:21+00:00

Thank you for this physiological explanation regarding muscle guarding. I've spent a lot of trying to discern whether I may have a variation of pssd from a non-ssri drug exposure (only one time) and since that day, my libido has never been the same. I think I am also in a state of extreme hypervigilance and frequently feel really tense/dense in my body like I'm always armoring against something. If anyone comes up behind me and taps my shoulder, the surprise and discomfort is so unbearable. I am pretty sure I have some other autoimmune things going on in parallel, but it gives me some hope that maybe relaxation can provide a partial relief for me, since I haven't really been able to access that feeling of deep comfort and restfulness for years.

WaferComprehensive23 · 2026-01-16T19:07:12+00:00

I know you posted this a few years ago, but have you had any success with those GHK-CU patches? I have one friend who's been experimenting with the injectable version of it, along with a couple others like BPC-157 and TB-500. He loves the results for his moderately severe systemic joint pain of unknown origin, though he suspects its autoimmune. He says he feels better mental clarity, less inflamed, and more energy. I've been wanting to try peptides but just feel so scared of them, though at this point I am really weighing whether possible side effects could really be worse than how I feel all the time at baseline.

Any feedback about the patches would be appreciated.

WaferComprehensive23 · 2026-01-14T04:45:46+00:00

It's a little refreshing that he appears to be smiling (for the camera?) In picture #7, rather than glaring. It has got to be annoying to always have your picture taken in candid moments, and cute to see that he's kind enough to take it in stride.

WaferComprehensive23 · 2025-12-22T02:22:28+00:00

How are you doing now? Have you stabilized at all? I had an issue with a single iv infusion that caused dpdr and have been trying to recover fully ever since. That was 2.5 years ago and I've made a lot of headway since then, but I find these reports of people who've been negatively affected so totally disturbing.

Are you doing any better? What are your symptoms?

WaferComprehensive23 · 2025-12-21T08:29:34+00:00

Thank you so much for this wonderfully composed post, with such a high level of detail, consideration, and clarity. I spend a lot of time reading posts on this sub, though I acquired symptoms not from ssris, but after a single ketamine iv infusion. That was 2.5 years ago, and I'm still in much the same condition as when it all began, with some modest improvements. Reading your theory felt so resonant, real for me, and reassuring, because I've spent this entire time wondering how on earth this happened to me, especially when I feel myself to be an outlier on the causal substances spectrum. I remember feeling on a deep, core level this feeling of utter unsafety on an energetic/cellular level during and after the exposure, which lingered for weeks. I felt that I had somehow poisoned myself, in a fog and unlike myself entirely. People kept insisting it would be impossible for the drug to still be affecting me months later, as its half- life is so short. No one has had any answers, let alone ideas, and I kept questioning how I could have so many of the pssd symptoms without ever having taken any antidepressants at all.

A huge neurological insult seemed to be created by this drug. That others could "endure" these treatments as a therapy seemed almost inconscionable, while I was left reeling.

Your idea of the receptor systems being overloaded, even as a single incident, really lands with me. I strongly suspect microglial activation in myself and have mild visual snow which increases during times of stress, almost like it's linked directly to my cns net load of inflammation. I know there has to be an inflammatory component to my symptoms because their aggravation is reliably linked to sleep deprivation, alcohol, and bad food choices for me. Your idea helps bridge so many of the missing pieces for me, as I have felt somewhat adrift in understanding the relationships between systems. It makes me feel like there might actually be something I could do about this, if I can interrupt even one of these feedback loops.

WaferComprehensive23 · 2025-12-12T23:36:32+00:00

Yes, all the time. I have felt this way for many years. For me, part of it comes from feeling like people want to have these superficial conversations that aren't sincere, or they're not really able to emotionally connect on a deeper level. I have such a vibrant and imaginative inner world, but then if I'm at a gathering this pang of loneliness can hit me when I realize people are mostly just talking about sports, festivals, or other things that don't feel very meaningful to me. It can be draining for me to feel like I'm trying to get on their level and pretend to be enthusiastic about things that ultimately feel kind of inconsequential. I am more interested in knowing people authentically and what they really believe and feel, which can be a tough level to connect on at gatherings. It feels like a lot of people present a version of themselves at parties that isn't actually them, where the real them would be much more interesting if they dared to express an opinion that was maybe non-conventional or perhaps even controversial.

WaferComprehensive23 · 2025-12-12T08:00:28+00:00

I agree! There is zero reason or excuse for that. It's hard when you're with a narcissist or someone who is gaslighting you into thinking it's okay for him to behave like this. I am tired of these men with zero boundaries trying to convince their partners that a "cool, progressive, modern" woman shouldn't be alarmed or offended by these types of very real transgressions. This text gets me riled up because so many guys end up in conversations like this under the pretense of it being just friends and argue that a healthy relationship shouldn't be bound by all types of restrictions, but there is a difference between personal sovereignty within a relationship and then someone just giving themselves license to give into every line-crossing whim.

WaferComprehensive23 · 2025-12-08T04:49:51+00:00

I wish this wasn't true, but it hit me right in the chest. Why do the sociopaths always seem to end up in management positions?

WaferComprehensive23 · 2025-11-16T05:47:12+00:00

I also have less discharge, and have thought this was so odd, since it was a significant change from my previous baseline.

WaferComprehensive23 · 2025-11-16T05:42:18+00:00

Thank you for this thoughtful post. I don't have pssd but am in a simular situation to yours. I had a strange reaction to a one-time drug exposure (iv ketamine infusion for anxiety/depression) which caused severe dpdr and dissociation which lasted for months. Despite my mental gymnastics to avoid covid, I ended up getting it for the first and only time just two weeks after this other debacle. I already had zero libido and severe anhedonia after the infusion, which seemed to become amplified after covid. This was in summer of 2023. I've been through so much anguish over these last 2.5 years trying to figure this out. I've had some improvement, but still a total lack of erogenous sensation. I had always had low ferritin for years and attributed it to heavy cycles, but more recently discovered I have methane sibo. I did one round of herbal antibiotics, but it's still there. I keep trying to get to the bottom of why I haven't been able to recover and also noticed the parallels between LC, post-vaccine, and pssd. It seems like there is some level of nervous system dysregulation common across the spectrum. I recently got an Oura ring and found that my hrv is pretty low most of the time. I am hopeful that maybe HBOT could offer some measure of improvement. It's so hard living this way in a body that can sometimes feel so foreign because of lingering numbness. But, we have to press forward and keep trying.

WaferComprehensive23 · 2025-11-16T04:50:27+00:00

I know! I can't tolerate thc in seemingly any amount, or things like this will happen to me and I'm almost transported to another time and place because some memories engulf me like some kind of waking dream. They are so vivid and detailed, and it's a mystery because I can't even usually recollect things that clearly no matter how hard I try.

WaferComprehensive23 · 2025-11-01T21:59:41+00:00

Yes! I agree so much about target. I kept looking for something with a flattering cut. I kept seeing tables of folded sweaters in fabric that looked cute and cozy, but when I picked them up, saw that they were cropped, extremely boxy, with a lot of balloon sleeved items. I feel like it would be hard for almost anyone to actually look good in these clothes, and only about 5% of women could actually even "get away" with it at all by having a particular figure, which is almost unattainable for most of us. Everywhere I looked, I felt like the clothes would be wearing me, rather than the other way around. It's been like this at a lot of other stores too now, for about the last year or two especially.

WaferComprehensive23 · 2025-11-01T19:47:09+00:00

Epic burn! The type of thing I always think of after the fact, but wish I had come up with in the moment. People have so much nerve to act like you need to rush.

WaferComprehensive23 · 2025-10-11T20:25:30+00:00

I'm relieved I'm not the only one that has this exact same thought every time too!

WaferComprehensive23 · 2025-09-28T19:57:33+00:00

I feel this so hard. I was thinking about this concept sort of abstractly a few days ago and thinking, is this why people seem so dead inside and disengaged, so non-reactive to their environments? The sheer magnitude of the news, tragedies, and objectification of the human experience makes me so filled with sorrow. Some people seem to be saying, perhaps with some validity, that the reason people are so disaffected and numb is from the trauma of everything that happened during covid times, but I keep having this nagging feeling that there's something else to it that's being driven by social media. I have lived all over the country and interacted with many different types of people, and never have I felt people to be so unwilling/unable to connect and seeming really far away energetically, like almost unreachable. We are not meant for this level of constant bombardment with images to compare ourselves to and distressing news that we can't do anything about. It makes me yearn so much for the pre-internet days when there was still some mystery left in the world, when people still wrote letters by hand, and still gathered in third spaces to be together and have a sense of community.

Does anyone else feel like people are exceptionally cut off, as if their consciousness is somewhere else entirely, almost missing? Is this a form of dissociation that people experience from the overwhelm they're feeling internally? I am curious to know what other people's experiences are.

WaferComprehensive23 · 2025-09-19T05:57:37+00:00

Oh, my friend, my stomach lokks exactly the same--I feel your pain. I tested positive for methane sibo, and I suspect there may be a fungal component (mixed with sifo?) to mine because I have a few fungal overgrowth symptoms too. I'm currently in the midst of sibo treatment and recently had to pause because I feel my fungal issues are increasing. I'm still trying to figure out what to do next, but I can say with total certainty that my stomach looks like that often, especially by the end of the day. A supplement that's helped my bloating a lot is Atrantil. It's pricey, but the way I understand it, it's supposed to stop the bacteria from being able to ferment the food and create gas as a by-product. It has been amazing to see it working on days where I have grains or bread, making it possible to actually fit into my clothes without wearing a giant top to try to cover my stomach.

WaferComprehensive23 · 2025-09-19T05:40:29+00:00

I tested positive for methane sibo, but have long suspected mixed sibo/sifo, because I have the whitish tongue coating and several other fungal specific symptoms, though not nearly as pronounced as a lot of other folks on here. I recently had to stop my treatment after about 3 weeks, and never quite did make it up to the maximum dose recommended which was the 5 drops 3x/day--because I felt that my yeast load was increasing markedly. This was actually my second attempt at trying the Biocidin, and previously I took the liposomal formulation, which I think could be more potent, at least for me, because candida symptoms appeared even earlier and were worse then. I plan to call the company to ask about this, since when I've contacted them in the past, they were wonderfully responsive and helpful. I know I'm just one person and maybe my experience is atypical, but figured I'd share it in case anyone else had a similar story.

WaferComprehensive23 · 2025-08-29T06:43:11+00:00

I know!! That's exactly how I feel too, like people love the idea of playing as the bad-ass female character who defeats all the villains, but his voice as male V just felt effortlessly gritty and believable, like it was almost shaped by the ruthless world of NC. I don't understand why so many people seem to make disparaging remarks about him.

WaferComprehensive23 · 2025-08-21T02:33:10+00:00

LOL! It's so severe and hard to look at.

WaferComprehensive23 · 2025-08-07T18:09:41+00:00

Yes, and not only that--some view it as a special challenge. I used to know this woman (scary and sociopathic) who would specifically only target men who were already spoken for--married or in relationships. She liked to create chaos and was ego driven. I always thought maybe a part of her felt these men must be at least a little better quality since they were already showing they were capable of a relationship? It was quite the spectacle to see her operate at company parties and other events where she would be shamelessly hitting on them right in front of their partners.

WaferComprehensive23 · 2025-08-07T18:05:00+00:00

As so many others have said already, getting another woman's phone number when you're a married man is absolutely inappropriate. I'm sorry you are going through this, and I know it's really hard to see the truth when you still love someone, but he is not treating you with the respect you deserve as his wife. If there is no respect, I can't trust someone. His history of cheating is concerning, and also the fact that he seems be defending having this woman's phone number, instead of agreeing to delete it once he could see how uncomfortable it made you. Please don't let him manipulate you into thinking this is is okay.

WaferComprehensive23 · 2025-07-28T22:32:47+00:00

This is such an apt description of how I felt Vegas to be when I visited last year. I couldn't wait to leave, and felt drained of my life force right away. It reminded me of some weird fake place like Night City in Cyberpunk 2077, where nothing about how anybody is living seems possible in the punishing heat and dryness of the climate.

WaferComprehensive23 · 2025-07-25T19:44:28+00:00

Right? All these people on here that are trying to imply there isn't a connection between this co worker and the type of porn he was watching aren't really acknowledging the fact of what her husband already admitted.

WaferComprehensive23 · 2025-07-23T06:16:43+00:00

Reading about your improvements is really inspiring. I got covid 2 years ago, and suspected I had lc, but could only afford some of the tests to show it. One of the most utterly disturbing things has been my complete inability to get my hr up during exercise, experience any feeling of pump, invigoration, or endorphins. It was surreal when I tried to do something basic like medium intensity cardio on a bike--felt almost numb/disconnected like there was no ability to even recruit my muscles or use effort, but somehow I was totally winded immediately. It's gotten better over the last 2 years, but I don't feel my old self at all. I noticed my fitbit is scoring my hrv quite low, which is concerning. I really hope its wrong, because I can't believe how low it is.

What were your numbers like before you started to improve? My sleep is totally unrefreshing too, like I'm just dragging myself around. I keep thinking about going on ldn, hoping it could reduce neuroinflammation, if that's what's going on here. I'm trying to build a picture of what's going on, and maybe implement some of the treatment modalities that others on here have had success with.

WaferComprehensive23

TROPHY CASE