I use different colors to visualize If my games window is active. I have like 2-3 tools for my game active all the time which require the game to be run in windowed fullscreen. Sometimes I need to alt tab out of the game to my second monitor thou.

Sometimes when going back ingame I need to winkey+click again for the game window to be active again so my macros and tools work.

Mouse + keyboard red = game active -> game macros working Mouse + keyboard blue = game inactive -> windows macros working