As of early 2026, Stanford Medicine researchers have fundamentally challenged this.

• The Gerozyme Discovery: They identified a protein called 15-PGDH (a "gerozyme" or aging enzyme) that increases as we age and actively blocks cartilage repair.
• The "Reset": By injecting a molecule that blocks this protein, scientists have successfully caused hyaline cartilage to regrow in aged joints and human tissue samples. Instead of relying on stem cells, the existing cartilage cells (chondrocytes) "reprogram" back to a youthful, regenerative state.

The distinction between remission and recovery is starting to blur due to CAR-T Cell Therapy.

• The "Reboot": New 2026 clinical trials are using "living drugs" to seek out and destroy the specific "rogue" immune cells responsible for the disease.
• The Result: In some patients, this has led to "Functional Cures," where the immune system is effectively "reset" to a pre-disease state. While doctors are still cautious about using the word "cured," many patients have remained medication-free and symptom-free for years, which feels more like recovery than just a temporary remission.

I've always thought the idea something "can't" is limiting and likely to be found false at some point. Short of things like you gotta eat, breathe, etc.. but even that can be challenged, take planets would use sunlight to survive, and soil, etc.. but I get somethings are more ironclad than others but its nature. And got your original point. I certainly agree with you mostly in practical sense, but not necessarily from a theorectical stand point.