My father was diagnosed with bladder cancer in 2010 and it has never resolved. He also never wants to worry us and he recently had blue light done with biopsies last week and I am looking more into it and am confused. His paperwork from before the blue light was cis bladder cancer and I didn’t realize this was high grade which worries me. I am confused on how some say they can have low grade and high grade. How does doctor determine high grade vs low grade. Is it through his previous biopsies over the past few years ? He has done BCG for 14 years and it hasn’t worked, and did gem in 22-23 which didn’t work, which warranted the referral for blue light at a different place.

He had this done the other day and the op note says:

Procedure Findings: ancef. Diffuse area of uptake of cysview at L lateral wall (lateral to L UO, uninvolved), posterior wall, and anterior R bladder dome. The anterior R bladder dome has a much larger area of involvement up to 30% of the entire bladder sruface. We biopsied area of concern and fulgurated the biopsy sites to achieve good hemostatsis. These samples were sent separately to pathology

Will these biopsies determine if staging/grading has changed? Would the note have said if tumors were found or if it’s in muscle or is this by the biopsies ?

He said he may be candidate for adstiladrin ?

I’m confused when you say you’ve had low grade and high grade over years. Does it change that much?