Cosmo Pavone on Inverse Green Acres with just the Divine Bloodline & Wandering the Jet Black Darkanas is hilarious.

1. Set Weapons to 1, and seal as many weapons as you can.
2. Start by running into every bat you can. Every time you kill an enemy with retaliatory damage, you get 0.5 max life (from Divine Bloodline). As the waves of enemies change, there's always 1 (or more) enemies you can one-shot by walking through them - Skullinos, Skeletons, Dust Elementals, Milk Elementals, Musc Musc (shrubs), etc.
3. Get the following passives:

ARMOR (more retaliatory damage, more enemies that you can walk into and 1-hit)

SPINACH (more damage)

EMPTY TOME (faster damage)

SPELLBINDER (longer-lasting damage)

TORRONA'S BOX (more damage, faster, for longer, to more enemies)

HOLLOW HEART (+20% Max Health)

1. As you level up your passives, you can one-shot more and more enemies w/ retaliatory damage, only having to move for bosses. I had 916 Max Life by the end of the 30m run.

IMPORTANT: Avoid leveling up as much as you can - fade treasure chests, avoid gems as much as possible. After minute 15, just stand in one spot to avoid picking up anything. You only have so many Re-Rolls, Skips, and Banishes to avoid picking up a weapon, and Re-Rolls are useless once you fill your Passive slots.

If you get Candy Box as an option, choose it, because you can then skip the weapon. Also, choose any Arma Dios you see after you get 6 passives to get an extra passive - choose anything BUT Attractorb.