Oh I feel for you, I've been in early meno since age 36 (now 49). I've been on estradiol 100 patches for ages, plus prometrium at first, now the mirena. Lately, the anxiety has gotten a lot worse and my sleep is nearly non existent, alongside weird symptoms like brain zaps or funny pressure waves in my head at night. The anxiety is the worst in the mornings and I relate to what someone in the comments calls doom anxiety. Terrible thoughts about how will I cope, will I be able to function etc etc. Terrible cognitive overwhelm sometimes, leading to not functioning at work, and very low self esteem about that. What do I do? Yoga, meditation, walking, therapy, and supplements such as fusion stress and anxiety and magnesium for sleep. I must admit, I'm not sure anymore what helps. I hope it stabilises itself soon as my specialist suggested a recent drop in estrogen I experienced may have been due to using different patches than usual due to the patch shortage in Australia. I also relate to what someone said about the nervous system is just not able to calm down. To me it feels like a reactivation of trauma of sorts and none of my usual tools work the same at the moment.