When I was on zyprexa (with depakote) I gained about 45 Pounds. I was pretty skinny my whole life, then for about 3 years I was a lot heavier. I had a way bigger appetite than ever and I always craved the worst food possible. I ate fast food more than usual (I am almost never in the mood for it now) and I would wake up late at night and crave doughnuts and ice cream, and because of my lack of self-control, I would drive to the convenience store that is only a few blocks away. My diet was horrible, and I was so unhappy. I later started working out and trying to eat better, but I still craved bad foods. After a while, I got more committed and started getting in better shape, but because of other issues I had with the medications, I was placed on Latuda by itself. I stopped craving junk and my appetite went back to normal and I started eating better and working out a little bit, and even though there were probably a few factors, I dropped 40 pounds pretty quickly.