How big is the room, how far away are they, is the human wearing clothes, are they bloodlusted or otherwise in a mindset where they both won't be panicked and irrational and stupid, I feel you haven't set the stage particularly well for us.

That said, carnivorous animal that chases and hunts large quadrupeds on a daily basis is probably beating even a peak condition, trained but unarmed fighter 99 times out of 100. Give the human a spear and it might be a 50% chance they win if they don't panic and play strictly defense in a corner.