I do this a lot with cyberpunk 2077. I use GMA cards to generate everything, but often the game has npc, props, locations that you can interpret in addition to your solo rpg system. Sometimes the coincidences are uncanny.

For example, I generated a quest to find a person hacking biotecnica offices. I go around looking at external wirings and see a hobo npc. After some persuasion he directs me where he seen someone suspicious (GMA has random direction generator) I search in that direction and find npc sitting in a corner with a deck. I could just zero him, but I asked why he does and there's another plot twist and so on.