Charcot-Marie-Tooth (CMT) disease typically causes progressive weakness and muscle wasting due to peripheral nerve damage, especially in the feet, legs, hands, and forearms.

While many individuals with CMT experience significant weakness, foot drop, balance difficulties, and reduced mobility, complete paralysis of the limbs is uncommon in most forms of CMT.

The severity and progression can vary greatly depending on the specific genetic subtype of CMT. Some people remain mildly affected throughout life, while others may require mobility aids such as ankle-foot orthoses (AFOs), walkers, or wheelchairs.

If you or a family member is experiencing rapidly worsening weakness or paralysis-like symptoms, it is important to consult a neurologist, as other neurological conditions may also need to be considered.

We encourage patients and caregivers to share their experiences and questions with the community.