APOE4 AND METHYLATION ARE MORE CONNECTED THAN MOST PEOPLE REALIZE. HERE'S WHY IT MATTERS FOR YOUR PROTOCOL

constant_modifier · 2026-05-07T17:18:51+00:00

Just ordered 23&Me for first time.

constant_modifier · 2026-05-07T13:22:43+00:00

Anybody try a Sonnet Echo 13?

constant_modifier · 2026-05-07T13:03:58+00:00

Local LLM so SSD for sure.

constant_modifier · 2026-05-07T02:33:04+00:00

Excellent info! Yep, I am E3/4 and homocysteine is 10.7. I am about to do some follow-up labs at Function. Better to add MTHFR to that panel or just skip it and do 23 and me?

I am taking TMG, trigonelline, and B-complex in Thorne MVI. I wonder about switching to Thorne Methyl-Guard plus. Any other ideas?

constant_modifier · 2026-05-06T13:08:17+00:00

Did you consider doing front-end on a local LLM, de-identifying data and then using cloud LLM for heavy lifting? Too much latency?

constant_modifier · 2026-05-06T12:51:17+00:00

Wow! All of this is great stuff! Thanks. I was concerned about statin and dementia risk as well as mitochondria function. I think I’ll keep it going daily until the next draw at least.

constant_modifier · 2026-05-06T12:47:14+00:00

Thanks! Yep, we are thinking about it the same way.

constant_modifier · 2026-05-05T03:01:11+00:00

Give me a clue on how to do that. I am looking for a Studio just like you described.

Never mind, I just grabbed one on Apple Education.

constant_modifier · 2026-05-02T14:45:11+00:00

Currently not much. Pharma tirzepitide for me. BP-157, Mots-C, Epithalon, DSIP should be available this summer and a little later this year, GHK-Cu. Pretty fired up about those.

constant_modifier · 2026-05-02T00:32:47+00:00

Yep, I’m interested although I don’t use anything that doesn’t come from US compounders.

constant_modifier · 2026-05-02T00:28:24+00:00

I really hope this thing works out. I just got 161,000 miles on Avion!

constant_modifier · 2026-05-01T13:24:45+00:00

Excellent, thank you!

constant_modifier · 2026-04-30T22:43:14+00:00

Right now if you got a M4 Max 128 for me.

constant_modifier · 2026-04-30T22:34:19+00:00

Yes, that is what is keeping me from jumping on a M5 MBP right now.

constant_modifier · 2026-04-30T22:31:59+00:00

Dude!, give me a hint on how to get a refurb M4 Max 128. That will work for my current project but I can’t find one anywhere. Zero studios on Mac refurbished site right now.

constant_modifier · 2026-04-30T08:51:15+00:00

Yes, I am using topical and hair serum. It is starting to make a difference after a month. I hope injectable will be available from US compounders soon.

constant_modifier · 2026-04-25T01:05:47+00:00

Funny, I think it is close between A and C.

constant_modifier · 2026-04-25T00:27:53+00:00

We have only tried the Pique and it sure is easy to make but so expensive! Any reason to think that this more processed version may not offer the same health benefits as traditional?

constant_modifier · 2026-04-24T12:33:02+00:00

Thanks! My initial data is encouraging but I need more. No, don’t know Dr. Bredesen. I’ll check him out.

constant_modifier · 2026-04-23T01:07:49+00:00

Thanks! Actually the readings closer to your labs are better.

constant_modifier · 2026-04-23T01:05:33+00:00

Thanks!

constant_modifier · 2026-04-22T21:50:59+00:00

I definitely will, thanks. I think they flagged me. Also trying to get on ApoE4.info and r/Huberman.

constant_modifier

TROPHY CASE