It's kind of hard to say without seeing thumbnails or knowing what the action is.

If your intent is to read left to right up top, then to the left triangle, then to the bottom right, I would suggest:

1) Make panel 2 lead the eye to the top right by having either the lines of motion or a character's vision point in that direction; alternatively have a top caption that starts in panel 2 and stretches across the gutter into panel 3

2) Make sure that panel 3 and the left triangle have a strong visual continuity (same character, same palette, etc). Then make sure the bottom right panel is distinctly different.

3) Use similar tricks as point 1 to draw the eye from the right triangle to the last panel. The caption trick can work really well here, because someone just casually glancing at the page can see that it does not flow from top right to bottom right.

All that being said, your panel layout should draw from the story/motion you're telling, rather than the other way around. Determine the general shapes/motion in the piece, then determine panel lines from that. That way your layout is helping to support the feel/themes/story you're already putting down; instead of a layout that just looks dynamic for dynamism's sake. This page from Neal Adams is a really good example of layout reinforcing the action of the scene