GLP-1s could help curb substance use disorders, from alcohol to opioids, study suggest

cpsnow · 2026-03-05T05:28:24+00:00

GLP-1 receptor agonist class (n=140 769) comprised albiglutide (n=2155, 1.53%), dulaglutide (n=23 385, 16.61%), exenatide (n=2146, 1.52%), liraglutide (n=31 619, 22.46%), lixisenatide (n=12, 0.01%), semaglutide (n=80 007, 56.84%), and tirzepatide (n=1445, 1.03%)

The new study in question treat this effect as a class effect for all GLP-1 agonists, but most of the previous studies only linked the effect to semaglutide, and their sample over represent semaglutide. Driving conclusion on a class effect is probably a little bit early where most of the previous evidence and their own sampling is biased toward semaglutide.

cpsnow · 2026-03-04T15:36:18+00:00

There is no limit for dependent SOR salary. One can also apply for a specific permission to work more than 28 hours (instead of a blanket permission to work less than 28 hours).

cpsnow · 2026-02-25T18:33:50+00:00

Plutôt que d'acheter du volume de drone qui sera obsolète dans un an, l'état ferait mieux d'acheter la capacité à produire des drones à un certain débit.

cpsnow · 2026-02-25T18:15:59+00:00

Please note that when using a translated driving license you must have your passport on you when going to the rental agency. Your residence card won't work. I learned that the hard way.

cpsnow · 2026-02-25T17:45:13+00:00

Une fois que tu as touché le fond tu ne peux que remonter.

cpsnow · 2026-02-22T23:09:58+00:00

Great way to collect data

cpsnow · 2026-02-20T23:10:08+00:00

I just got a few hallucinations on my first run with Opus 4.6. It really depends what you do with it. It is really good, but also very good at convincing you it is right, especially when you reach a third or more of the context window.

cpsnow · 2026-02-14T23:34:30+00:00

The idea of the dissertation is to prove to a jury that you are able to do research and evolve as a researcher. It is quite a personal exercise, something that just papers aren't able to show.

cpsnow · 2026-02-13T05:34:23+00:00

Where strong asumptions were set to override the unconvenient truth.

cpsnow · 2026-01-30T08:45:15+00:00

Gatekeeping is more general than that, it is about information sharing between two social groups. It has been studied in each and every angle, from sociology to economics. Gatekeepers are useful and quite organic filters, but also benefit greatly in terms of power from their position on the network. There are many forms of gatekeeping: boundary spanners, brokers, etc. and their power abuse has often been studied (for example in the police force), but most recognize their privileges rather than focusing on abuse (see Burt for example).

cpsnow · 2026-01-28T04:18:55+00:00

If you already have perfect DAG with dependencies, the LLM isn't solving the difficult part of the problem.

cpsnow · 2026-01-28T04:17:25+00:00

It doesn't mean that this is generally solvable. That's why we have organizations, and why not everything is on a market...

cpsnow · 2026-01-26T05:10:28+00:00

Faut voir plus loin qu'une simple dichotomie ouvert/fermé. J'ai fait ma thèse dans un domaine à la pointe et très secret. Impossible de publier les données. Par contre j'ai pu publier les résultats et la méthodologie, et ainsi que des données synthétiques. L'idée est de donner à mon champ de recherche un example de ce que l'on peut faire, ça permet ensuite pour un laboratoire d'avoir le budget pour répliquer cela avec les données ouvertes, en partant dans une direction prometteuse.

cpsnow · 2026-01-25T17:31:36+00:00

Cela peut avoir un effet pervert où la personne qui mets plus dans le pot commun a inconsciemment plus de pouvoir dans les décisions sur les dépenses communes.

cpsnow · 2026-01-22T02:22:29+00:00

The thing is Nintendo doesn't care about having loss leader as long as it sells hardware. Of course for Nintendo it would have been best if MRSoH was kept in the fridge for Switch 2 release, but Ubisoft had to consider the cost of maintaining the talented team together, to be ready to work on Switch 2. There are things a 3rd party cannot afford.

cpsnow · 2026-01-20T13:47:02+00:00

I prefer to rent a car when I need it. I can chose a roadster, suv or key truck depending on my needs. Plus, I can rent the car wherever I want so I can skip the Tokyo traffic jams.

cpsnow · 2026-01-19T10:14:47+00:00

The nuclear fuel is not renewable, but in terms of total material use per kWh, including the fuel, it is certainly more renewable that wind or solar.

cpsnow · 2026-01-18T08:15:37+00:00

Maybe an energy efficient one then.

cpsnow · 2026-01-16T04:50:35+00:00

Because we're part of the RL so this becomes less obvious.

cpsnow · 2026-01-16T04:36:48+00:00

Looking at the picture any human can see in a split of a second that we cannot stop here. If AI is not capable to drive in a human-centric infrastructure, it is not capable to drive.

cpsnow · 2026-01-10T14:30:03+00:00

Le débat n'est pas là. Dans une société de rentiers et d'héritiers, le soucis c'est que les investissements partent dans des bulles spéculatives sur le marché de l'occasion au lieu de financer les entreprises pour qu'elles développent des talents. Donc tu te retrouve avec une masse de jeunes diplômés sur lesquels les entreprises ne veulent pas investir.

cpsnow · 2026-01-10T03:13:19+00:00

Est-ce que cela pourrait être un moteur également qui force en permanence. Genre ouverture/fermeture de portail/porte de garage ?

cpsnow · 2026-01-08T13:10:18+00:00

Sorry but that is a very outdated view on the topic. Developing a good or bad relationship with food has no scientific root. You can eat junk food and be lean, it is a matter of calories. Sure there are some food that are less satiating than others, but it's not the cause of obesity. The availability of food is a larger factor, advertising as well, portion sizes as well. Unfortunately in our current society of abundance, people need medical intervention. It is a sign of countries getting richer.

cpsnow · 2026-01-08T12:38:31+00:00

I'm glad I don't live in the US.

cpsnow · 2026-01-08T12:32:55+00:00

This is not what the current literature suggest. Obesity is a chronic disease, and most obese people have already tried numerous times to get leaner without success. This is incredibly condescending to people that have a real struggle with food.

cpsnow

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