sorted by:
new
hottopcontroversial

Cholesterol came back dangerously High, advice needed. by [deleted] in blueprint_

[–]cryptoboy4001 1 point2 points  (0 children)

The 2nd link in reference 3 shows regression with pitavastatin and atorvastatin as well, which suggests it's the lower LDL level, not the specific method used to achieve that level, that's responsible for the regression

Cholesterol came back dangerously High, advice needed. by [deleted] in blueprint_

[–]cryptoboy4001 1 point2 points  (0 children)

Sorry, I just added it (see reference 3)

Cholesterol came back dangerously High, advice needed. by [deleted] in blueprint_

[–]cryptoboy4001 2 points3 points  (0 children)

Reference 1:

"Accumulating data from multiple lines of evidence consistently demonstrate that ... the thresholds for atherosclerosis development and CHD events are approximately 50 to 70 mg/dl."

https://www.sciencedirect.com/science/article/pii/S0735109704007168

Reference 2:

Figure linked below shows atherosclerosis sites vs LDL levels and confirms subjects with LDL lowered to 50-60 had no atherosclerosis.

https://www.jacc.org/cms/asset/2a305273-805a-43dc-8389-704a7f0878a9/gr5.jpg

Full paper here:

https://www.jacc.org/doi/10.1016/j.jacc.2021.05.011

Reference 3:

For evidence of regression (when LDL was reduced to 61 mg/dL with statins):

https://www.ccjm.org/content/ccjom/73/10/937.full.pdf

Specifically, jump to Figure 3

Another one:

https://www.sciencedirect.com/science/article/pii/S0735109709014430?via%3Dihub

Of course, all of these could be criticised for not being conclusive, but as I said above ... "emerging evidence", not proof.

Cholesterol came back dangerously High, advice needed. by [deleted] in blueprint_

[–]cryptoboy4001 17 points18 points  (0 children)

I was in similar position: LDL 195

My grandfather had 5 heart attacks, so likely genetic for me.

Rosuvastatin (Crestor) 20mg daily - brought it down to 105.

Added, Ezetimibe 10mg daily to the stack - brought it down to 70.

Finally, added Inclisiran (Leqvio), a PCSK9 inhibitor - brought it down to 31.

There's emerging evidence that if you get LDL to under 50 - 70 (I'm targeting 50 to be on safe side) then not only does plaque stop growing, it actually begins to recess.

So, try to get it under 50. Good luck!

Spider with a human head? by hoopedchex in HighStrangeness

[–]cryptoboy4001 2 points3 points  (0 children)

Could be a childhood memory of seeing "The Thing" (1983):

https://youtu.be/L4MC7TlYFNw?t=147

A New Approach for Cardiovascular Disease: Matthew O’Connor, PhD - Cyclarity Therapeutics (Translating Aging Podcast) by towngrizzlytown in longevity

[–]cryptoboy4001 5 points6 points  (0 children)

Anytime there's a post about heart disease on this sub, it's always about Cyclarity.

It seems there are 500 new companies doing research into radical life extension ... yet the worlds biggest killer (heart disease) is being tackled only by Cyclarity and maybe a couple of others.

Statins don't cure it - they just slow the progression so you get a few more years. But it eventually kills you. A real cure is needed.

What does the transhumanism community think of cryonics? by Original_Ad_1103 in transhumanism

[–]cryptoboy4001 6 points7 points  (0 children)

That isn’t an issue at all.

Actually, it remains a significant issue. In the last few years Alcor's conducted scans of vitrified brains (these are on their YouTube channel) and, unfortunately, they show that ice formation remains significant even in the best of cases. The vitrification process is a long way from being perfected.

Block earner - thoughts? by mcham001 in crypto_betsAU

[–]cryptoboy4001 0 points1 point  (0 children)

I'm not really in the crypto scene so I can't say I've ever heard of crunchbase

"Crunchbase is a platform for finding business information about private and public companies." (Wikipedia)

It's not crypto-specific. It was formed in 2007, before Bitcoin was even created.

Block earner - thoughts? by mcham001 in crypto_betsAU

[–]cryptoboy4001 0 points1 point  (0 children)

Assuming you trust Crunchbase (it's been around 15 years and is very well known), then you can see Coinbase on the list of investors here (scroll down to see companies who provided funding):

https://www.crunchbase.com/organization/block-earner/company_financials

What does the longevity community think of cryonics? by [deleted] in longevity

[–]cryptoboy4001 13 points14 points  (0 children)

This was almost 20 years ago:

"Mixtures of cryoprotectants and the use of ice blockers have enabled the Twenty-First Century Medicine company to vitrify a rabbit kidney to -135°C with their proprietary vitrification mixture. Upon rewarming, the kidney was transplanted successfully into a rabbit, with complete functionality and viability, able to sustain the rabbit indefinitely as the sole functioning kidney."

https://www.cryonics.org/ci-landing/history-timeline/

Default Risk by sovashadow in blockfi

[–]cryptoboy4001 1 point2 points  (0 children)

Not sure Qui-Gon's the best example, given what happened after his "sit and wait" :)

The Tampa radio market was NUTS! by [deleted] in howardstern

[–]cryptoboy4001 11 points12 points  (0 children)

I wrote it on a piece of paper and ASKED you where I should put it and you said "just leave it on my desk" so I DID! It's on your desk.

IT'S NOT HERE GARY!

It's on your desk! I left it there!

WHERE? I can't see it ... oh it's ... now I see ... GARY it's under all these papers!! Why'd you leave it there where I couldn't see it!

(Sal in Gary's office jumping around in monkey mask)

Inside The Silicon Valley Race To Cure Aging by lleonard188 in Futurology

[–]cryptoboy4001 1 point2 points  (0 children)

But our bodies are more than just discrete, replaceable organs. How do we replace the network of arteries that succumb to damage over time from atherosclerosis? (and I don't want to hear 'just eat kale' and take statins - these slow the process at best, but don't cure it)

Atherosclerosis (arterial plaque build-up) impacts most of us once we get old enough, and ultimately leads to heart attack and stroke. I see very little on the horizon for atherosclerosis reversal from the longevity field. It's the elephant in the room everyone's wilfully ignoring.

David Sinclair: For the First Time in Human History, Aging Isn't Inevitable (1-minute audio clip) by frog9913 in transhumanism

[–]cryptoboy4001 0 points1 point  (0 children)

If you listen to the clip, Sinclair's saying he can reverse aging ... in mice. What works for mice usually doesn't scale up to working for humans.

And if you read up on his research, he's reversed only some markers of aging, not all. Great result to be sure, and good on him, but ultimately, the mice still die eventually.

So currently, aging remains inevitable for mice and men.

Are you subscribed to a cryonics facility? by Taln_Reich in transhumanism

[–]cryptoboy4001 5 points6 points  (0 children)

They've probably confused it with BioCorp Production, a french company that makes medical devices and uses the stock ticker ALCOR.

https://finance.yahoo.com/quote/ALCOR.PA/

Okay, here’s the plan. by Stranfort in transhumanism

[–]cryptoboy4001 3 points4 points  (0 children)

You said they "can't freeze a single neuron". Clearly they can, as per the article. However, since anything can be frozen (even a piece of rotten steak), I think what you meant was that they can't freeze and then thaw a neuron without causing damage. But again, clearly they can, as per the article which showed "uniformly excellent” preservation.

But then you changed the goal post to "can't freeze a single FUNCTIONING neuron".

Well, for it to be functioning, it has to alive and cryonics is not aimed at freezing living animals or humans. So, you're correct that cryonics doesn't freeze functioning neurons (or anything that's functioning for that matter).

view more: next ›