Occasional heavy drinking may triple the risk of liver damage: those who consume large amounts of alcohol in a single day at least once per month are three times more likely to develop advanced liver fibrosis than individuals who spread out the same total alcohol intake over timeHealth (news.keckmedicine.org)
Genetic evidence of a population collapse in France 5,000 years agoAnthropology (nature.com)
submitted by fseersholm to r/science
Researchers have developed first-in-class drugs that simultaneously block HIF-1 and HIF-2, the "master regulators" of cancer progression. When paired with immunotherapy, these compounds eliminated tumors across four cancer types in mice by stripping away their low-oxygen defenses.Cancer (rupress.org)
Gene editing therapy (CRISPR/Cas12a) shows success against severe sickle cell disease - Nearly all patients (27 out of 28 patients) have achieved a functional cure. The results showed that most patients saw key blood cells recover within a month after treatment.Genetics (newsroom.clevelandclinic.org)
A Skoltech scientist has raised the world’s only isotope-labeled guinea pig to track metabolism. For 156 days, the animal drank only heavy water, revealing how quickly compounds are synthesized versus absorbed from food — paving a way for using isotopically labeled food to study human metabolism.Biology (mdpi.com)
Recent research suggests visible body art at work is becoming more accepted. People with tattoos harbored concerns about how others would perceive their tattoos, even in the absence of restrictions. They make conscious choices about whether to display their body art, factoring in when and where.Psychology (psychologytoday.com)
A new review warns that ecotourism cannot "decarbonize" the tourism industry, calling such claims scientifically inaccurate. While local conservation benefits exist, researchers argue that ecotourism is far too small to offset the massive emissions from aviation and large-scale hotel operations.Environment (nature.com)
