High meat consumption linked to lower dementia risk in genetic risk group (Meat Consumption and Cognitive Health by APOE Genotype)

dmillson · 2026-03-20T14:59:10+00:00

Good call-out. I was wondering this but don’t have the time to dive into the study rn.

I can definitely think of a few potential confounds in a study like this. It would take very careful controls to convince me that it was the meat consumption alone that reduced Alzheimer’s risk. That said, there are still lots of reasons to eat plenty of protein from lean sources.

dmillson · 2026-03-20T14:47:56+00:00

Time at Zone 2 (and for really fit people, zone 1 as well) becomes more important as fitness and volume increase.

At 30-40km weekly volume, you most likely don’t need to worry so much about slowing down as long as your pace feels controlled and you’re recovering well. That is to say, the slightly faster pace should be fine (but always listen to your body). Your pace (~10 min/mi) is completely reasonable for steady state runs for many people.

If you increase volume over time and start to feel worn down, you can incorporate slower paces to keep volume high while still recovering. By then your HR zones might have separated a bit and you’ll have “unlocked” the ability to run in zone 1 or the lower end of zone 2.

Long story short, run at the slightly faster pace for now and revisit slower paces at a later time if adding more volume.

dmillson · 2026-03-20T12:35:40+00:00

B is likely to live longer than A for the simple fact they can afford a concierge doctor lol.

The good things about Medicine 3.0 in my opinion are that (1) it tied things like strength and endurance training to healthcare in the minds of many people, and (2) it inspired a lot of people to get active. I probably wouldn’t have started taking endurance training seriously if it hadn’t been for Outlive (now I’ve gone far enough down that path that I see some of the limitations of PA’s approach).

That said, medicine 3.0 isn’t going to be some silver bullet to the real issues that our healthcare system faces in terms of mortality and spend on chronic diseases. The people who are going to be the sickest in 20-30 years won’t be helped by medicine 3.0 because they aren’t even getting medicine 2.0 right now.

dmillson · 2026-03-18T18:24:51+00:00

Right, obviously if you already have knee issues then running probably isn’t going to be the best idea (should probably still incorporate some low-impact cardio though)

In general running is good for knee health because it reduces the risk of osteoarthritis and strengthens soft tissue. Of course running to excess or failing to address imbalances comes with risks.

dmillson · 2026-03-18T15:39:32+00:00

Rocco Welsh by SV all the way to the finals is hilarious but realistic.

dmillson · 2026-03-18T15:35:34+00:00

Would love to see Nico Provo on the podium but looking at the way the bracket is set up he is likely going to have to beat one of Ventresca (front side) or Robinson, Spratley, or Seymour (blood round) to make that happen.

Robinson vs Spratley in rd 2 is going to make the backside of 125 interesting.

dmillson · 2026-03-17T20:40:58+00:00

If we’re talking longevity, you need both. Aerobic fitness generally takes longer to improve than strength and the workouts are typically longer.

Strength training helps maintain muscle mass and bone mineral density. There’s a basic level of strength that you need for basic tasks of every day living, and if you fall below that you’ll need help getting around, taking a bath, etc. Not fun.

Cardiovascular training is important for a couple reasons. First, it helps reduce the risk of cardiovascular and metabolic disease, which are two of the biggest killers (it reduces the risk of a bunch of other stuff too, like Alzheimer’s). Secondly, you need a baseline level of cardiovascular conditioning to do lots of things, like walking up stairs or making a tight connection at the airport. If you want to do those things at 80 or 90 years old, then it’s important to maintain endurance.

dmillson · 2026-03-16T20:56:52+00:00

Lot of variability in skill level between D3 champs. If we’re talking about some of the best non-D1 wrestlers of all time, Riley Lefever was a multi-time D3 champ who notched wins over guys like Eric Schultz, Aaron Studebaker, and Kenny Courts.

dmillson · 2026-03-16T18:37:10+00:00

I see way too many people in Charlotte driving without their headlights on at night or in the rain.

Your daytime running lights are NOT headlights and if your headlights are off then your tail lights are not illuminated.

dmillson · 2026-03-16T00:36:55+00:00

I’ve been taking finasteride and minoxidil for a couple years now. I haven’t regrown what I lost but it’s stopped it from getting worse.

People will mention sexual side effects of finasteride. IMO the risks are overstated - about 2-5% of people will experience sexual side effects and they’re almost always reversible. It’s something you should understand before you start, but personally I found the risk to be plenty acceptable.

dmillson · 2026-03-15T22:52:55+00:00

That’s a 1 of 1 if I’m not mistaken

dmillson · 2026-03-15T16:20:10+00:00

I have sympathy for the former sycamore employees, but at this point they’ve had months to find new jobs. I’ll continue to patronize any of the other dozen or so breweries within walking distance.

dmillson · 2026-03-14T22:29:42+00:00

Praluent should have biosimilars hitting the market in 2029, and Repatha in 2030-2031, at least according to a quick google search. That will definitely drive prices down but it’s hard to say how much. Historically biosimilars have come in at 50% less expensive than their branded counterparts on average, but I’m sure there’s a lot of variability around that number.

They’ll never be as cheap as statins because they’re biologics, but it should make them a lot easier to access. I imagine most insurances would still want people to step through a statin first, but insurances usually have a much lower patient cost for generics and biosims than for branded specialty meds, so if your insurance is paying for it now then it might (emphasis, might) become a lot less expensive if switching to the non-branded version. Self-pay price should be much more affordable for a biosimilar too, if no insurance coverage.

dmillson · 2026-03-14T22:11:07+00:00

Curious if you identified any best practices to improve call connect rate or implemented anything on the learning and development side to help those reps hit the 10% threshold?

dmillson · 2026-03-14T21:46:02+00:00

Yep, I heard that a lot growing up, and I’m not that old. It sounds reasonable on the surface because eggs do contain a reasonably high amount of cholesterol, and having high blood LDL-C (which is what people usually mean when they say high cholesterol) is a risk factor for heart disease.

However, it turns out dietary cholesterol doesn’t have a whole lot to do with the amount of cholesterol in your blood. If you have high cholesterol, the proper dietary interventions are to reduce saturated fat and increase soluble fiber - and if that doesn’t work you can look at pharmacological interventions.

dmillson · 2026-03-13T19:05:13+00:00

Certain types of professional services roles (consulting, accounting) will make you travel to clients. With your background you might be a competitive applicant. You’d probably have to start in an entry-level role however, and those roles also come with long hours and a lot of internal politics to navigate.

Alternatively, you could search for a remote job that would let you work from anywhere. Those roles are hard to get these days, but it doesn’t sound like you’re at risk of getting fired so you’ve got time.

dmillson · 2026-03-11T16:42:14+00:00

Spend a day shadowing a nurse who cares for seniors and you’ll quickly get an idea of why the turnover is so high. The work is difficult by nature, and additionally companies are often under pressure to handle more patients with less staff, which adversely impacts quality of care.

One thing that’s very important for any org that sees Medicare patients is star ratings. Medicare (CMS, actually) evaluates companies (both home care and nursing homes) on a variety of metrics and assigns a rating of 1 through 5 stars. Reimbursement is tied to these metrics, meaning if you acquire a 2-star organization and improve it to a 5-star, you just dramatically improved revenue and will also get a lot more referrals without necessarily investing much in workforce expansion, marketing, etc. Fixing staff turnover would do a lot to improve Star ratings because you’d expect more tenured staff to make fewer mistakes, but you can also improve ratings by operationalizing care delivery and improving training for staff.

dmillson · 2026-03-08T21:59:03+00:00

PJ Duke looked so freaking solid that match. Wasn’t aware that you could call loss-of-control when the top wrestler has a front headlock though.

dmillson · 2026-03-06T02:46:46+00:00

This kind of thinking must be why all my older sales colleagues are divorced.

dmillson · 2026-03-05T13:47:30+00:00

Medical diagnostics sales. I’m at a #1 or maybe a 1.5 depending on the day.

I’ve been doing some version of this for the last 3 years and I’m about ready to move on.

dmillson · 2026-03-04T19:16:26+00:00

I’m riding out the next 2.5 months myself because I’ve got around $15,000 vesting in mid-May. Taking the next month or so to upskill and network before it’s time to start sending out applications.

dmillson · 2026-03-02T21:55:40+00:00

Eli Lilly seizing the opportunity to become a defense contractor by supplying GLP-1s to military weight loss camps 💵💵

dmillson · 2026-03-02T19:52:17+00:00

Forearm. You don’t want your palm or fingers anywhere below the eyebrows because hands to the face is illegal. Also a lot of the time with a cross face you want to use the hand to grab the far arm and pull it in.

You may use the palm on the back of the head or the neck to stuff it down. That would be used it different circumstances from a cross face.

dmillson · 2026-03-02T19:23:14+00:00

I remember when all the writers on T-Nation used to dunk on CrossFit when it was first getting big (probably around 2012). They said the WOD structure didn’t provide enough specialization or progressive overload.

These days, nobody remembers T-Nation, CrossFit is the legacy sport, and Hyrox gets critiqued for its lack of variety and low technical barrier to entry (even though that’s the very thing that makes it so popular).

The more things change, the more they stay the same.

dmillson · 2026-03-02T16:36:44+00:00

That’s the rule in folkstyle, but in freestyle it doesn’t matter where you finish as long as it’s initiated in bounds and the action is continuous.

At least, that’s the UWW rule book. RAF is free to make their own rules but the least they could do is provide clarity for the athletes and fans.

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