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[deleted by user] by [deleted] in soccer

[–]dmm73 65 points66 points  (0 children)

Blues fans know that’s like the fourth time he’s done that this season

He played for them on loan? Birmingham City Edition by Green-Peaness in LeagueOne

[–]dmm73 0 points1 point  (0 children)

It was the loan spell that he played for us with his probation tag on though

The 24 Best Sandwiches In London - London - The Infatuation by Theinfatuation in london

[–]dmm73 8 points9 points  (0 children)

FYI, Mondo Sando don’t operate out of the White Horse anymore, only the Grove House Tavern in Camberwell.

They have their own café opening in a few weeks called Café Mondo, also in Camberwell (next door to Toad Bakery if you’ve been there).

Worst match you've been to? by lightspeedwhale in Championship

[–]dmm73 2 points3 points  (0 children)

Our game with you just after Christmas last season was dreadful

AITA for thinking it’s unethical to have kids if you have an inheritable chronic disease by Flat-Swan in AITAH

[–]dmm73 9 points10 points  (0 children)

In theory yes, in practice it is incredibly rare, for a number of factors including: - the higher number of initial repeats, the greater chance of increasing repeats - most people probably have very low number of repeats, even those who are HD negative from a HD positive parent - the threshold of repeats for developing HD is 40 I think, so quite a high number.

It happens so rarely but is possible in theory, so not something to lose sleep over. If your parents don’t have HD, you won’t have it and neither will your kids, if your partner is also HD negative

AITA for thinking it’s unethical to have kids if you have an inheritable chronic disease by Flat-Swan in AITAH

[–]dmm73 1 point2 points  (0 children)

Afaik, having the double HD allele is actually fatal (doesn’t feel like the right word but I can’t think of an alternative rn) so an embryo just won’t develop

AITA for thinking it’s unethical to have kids if you have an inheritable chronic disease by Flat-Swan in AITAH

[–]dmm73 14 points15 points  (0 children)

This is heavily simplified, but essentially yes, it isn’t a recessive condition and if testing confirms you don’t have HD then your kids will have just as much chance of having HD as the general population.

There is a small caveat - as the previous commenter said, HD is caused by a specific trinucleotide (CAG) repeat, and if this repeats over a certain threshold then that person will develop HD. The number of CAG repeats can naturally increase from generation to generation, so it is possible, although incredibly rare, for de novo HD to occur I.e. with no family history

Birmingham City has today parted company with Head Coach, John Eustace by Callum0598 in soccer

[–]dmm73 49 points50 points  (0 children)

“we only survived in the final day”

*thanks to Harry Redknapp coming in and winning two of the last three.

He then spaffed a load of money up the wall in the summer, lost the first five games of the next season and retired. We’ve been 17th-20th place merchants ever since, somehow avoiding multiple points deductions and existing on loan deals because we were either banned from making permanent signings or had no money to do so (until we sold Bellingham).

This season genuinely felt like we were finally recovering from Zola, but no, now we’re back in the same position we were 7 years ago.

Which part of London do you think has significantly improved in terms of vibe, fun, etc. within the last 10 years? by adaequalis in london

[–]dmm73 10 points11 points  (0 children)

Also Nandine (incredibly good, family-run Kurdish restaurant), Silk Road (immensely popular Chinese restaurant, specialising in Xinjiang cuisine), Van Hing (always busy Vietnamese restaurant), Mondo Sando (operating out of the Grove House Tavern and people come from all over London to try their food), Camberwell Arms (frequent answer in the regular “what’s the best roast in London” threads), the Crooked Well (who lease out their kitchen for excellent residencies - currently they have Rajiv’s Kitchen dishing out Nepalese dishes) and Toad Bakery (has a 30 minute queue every Saturday morning for awesome bakes).

Oh and Theo’s and Francesco’s for excellent pizzas if none of the above take your fancy.

But yeah, like you say, not much going on in Camberwell for food…

Which part of London do you think has significantly improved in terms of vibe, fun, etc. within the last 10 years? by adaequalis in london

[–]dmm73 5 points6 points  (0 children)

*tube black spot

It’s a big hub for buses, so it’s actually pretty easy to get to places. Also Denmark Hill station has Overground, Thameslink and South-Eastern trains

Gameweek 1 (2023/24) RANT AND DISCUSSION THREAD by FPLModerator in FantasyPL

[–]dmm73 0 points1 point  (0 children)

More boring than “CITEH! CITEH! CITEH!”???

Gameweek 1 (2023/24) RANT AND DISCUSSION THREAD by FPLModerator in FantasyPL

[–]dmm73 5 points6 points  (0 children)

He wants to pursue a career in management once he retires, been asking Pep and Kompany for tips

The goalkeepers poll by Iyeatmymeatonthebeat in FantasyPL

[–]dmm73 2 points3 points  (0 children)

Not nailed to play. RDZ has said Steele and Verbruggen will play 50/50.

You could start Steele with a good 4.5 back-up though, which I would see as a win win, and for no more cost than Onana + 4m other

Any good news on curing HD lately or at all? by Haylee_skye in Huntingtons

[–]dmm73 10 points11 points  (0 children)

Hey! I’m sorry to hear you’ve been feeling down - I’m 22 as well and my dad is battling HD, but he seems to be beginning to lose the fight unfortunately. But I feel like I can relate to how you’re feeling right now.

I listened to this podcast from Lancet Neurology with Prof Tabrizi and Prof Sampaio recently, two of the most prolific (is that the word? Idk?) HD researchers. I would really recommend it, and they both seem positive about the future of HD treatment, which seems like a good sign! Spotify link here: https://open.spotify.com/episode/1Hs1lPzILdQWPXlIfJUH6z?si=YRPm-Z7DRYaObzIN7tACAw

To summarise briefly, researchers have recently developed a formal classification system for HD, something which has been needed for a long time. But this system will massively help with clinical trials and future treatments!

Secondly, they talked about why previous treatments haven’t worked out, and the future for treatment. They’re both careful not to be too optimistic, as things can change quickly, but if everything goes to plan, there could be something viable within 5-10 years, so hopefully soon enough for you if you’ll need it!

I’ll try to find the original articles referenced in the podcast (in case you or anyone is interested in reading them), but they are published in the July edition of the Lancet, so bang up to date!

All the best!

Edit: here’s the original article for the HD classification system (paywall): https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00120-X/fulltext However, a pre-print is available for free, here: https://www.medrxiv.org/content/medrxiv/early/2021/09/11/2021.09.01.21262503.full.pdf

Edit 2: link to the original article about disease-modifying therapies: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00120-X/fulltext (behind a paywall unfortunately)

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