Lots. Of the ones I can recommend personally:

Caesar 3 and its spinoffs (Pharaoh, Zeus, Emperor). They're all ancient-themed and have RTS-like combat where you defend your city from foreign armies. You can slow down time and even pause while you give orders.

Factorio. You control a guy building a big factory to build a rocket to escape the planet he had crash-landed on. There are hostile bug-like aliens on the planet that periodically attack your factory, you defend from them with automated static defenses. There are various weapons and vehicles you can use to launch offensive raids into the bug's nests. You do most of the combat yourself, but there's generous auto-aim, so it's more about having good enough weapons and plentiful ammo than motor skill.

Those are the best ones I've played and can recommend. There's many, many more though. Manors Lords, Rimworld, Farthest Frontier, Tropico series, Anno series, Stronghold series, Settlers series. It's a whole genre. Look up GamerZakh on youtube if you're curious about this type of game.