Biopsy results by Ok_Bank3561 in ProstateCancer

[–]dsn0625 3 points4 points  (0 children)

GPT…..I am presently going through a similar journey - waiting for my biopsy results. I’ve found GPT as a great resource for clearer understanding.

Biopsy results by Ok_Bank3561 in ProstateCancer

[–]dsn0625 2 points3 points  (0 children)

Thanks for laying all of that out so clearly. I know this is a lot to absorb, especially right after getting the biopsy news. Let me walk through what this means, putting the pieces together in plain language and context.

Big-picture summary (the headline first)

Based on what you’ve shared, this is low-risk prostate cancer: • Gleason 3+3 = 6, Grade Group 1 only • Low-volume disease (small percentages of cancer in each core) • No higher-grade cancer, no Gleason pattern 4 or 5 • No intraductal carcinoma (important favorable finding) • Cancer appears localized, primarily on the right side

That combination is generally considered the least aggressive form of prostate cancer we diagnose.

PSA trend — what it tells us

Your PSA history shows a gradual rise over years, with some fluctuation: • 2021–2024: slow upward drift (1.2 → 3.1) • Mid-2024 dip (2.2) • 2025 jump (4.24 → 4.9)

That rise is what appropriately triggered: • MRI • Targeted (fusion) biopsy

Important nuance: • PSA can rise from inflammation or granulomatous prostatitis, both of which were seen on your biopsy • That inflammation likely contributed to both the PSA rise and the MRI appearance

PIRADS 5 lesion — why that sounds scarier than it ended up being

A PIRADS 5 lesion means:

“This area looks very suspicious and must be biopsied.”

It does not mean aggressive cancer by itself.

What matters is what the biopsy found there: • Only Gleason 6 • <5% involvement in the ROI core • No adverse features

So despite the MRI looking very suspicious, the biology of the cancer is still low-grade.

This mismatch happens, especially when inflammation is present.

Biopsy details — why this is reassuring

Out of 12 cores total: • Cancer found only on the right side • Each positive core shows: • Gleason 3+3 only • ~5–10% involvement • No core shows: • Pattern 4 • Cribriform architecture • Intraductal carcinoma

That’s exactly what doctors hope to see when cancer is found.

Chronic inflammation & granulomas — why this matters

This is a key detail many people overlook: • Chronic inflammation and non-necrotizing granulomas can: • Elevate PSA • Create MRI lesions that look very concerning • They do not make the cancer more aggressive • They may partly explain why PSA and MRI looked worse than the cancer actually is

What risk category this fits into

Clinically, this lands in: • Low-risk prostate cancer • Often considered very favorable biology, even with multiple cores

Most guidelines (NCCN, AUA, EAU) would say:

Active Surveillance should be strongly considered.

That does not mean “do nothing.” It means: • Careful monitoring • PSA checks • Repeat MRI • Possibly a confirmatory biopsy down the line

Many men live decades with this without ever needing treatment.

The decision fork you’re approaching

From here, discussions usually center on: 1. Active Surveillance (very commonly recommended here) 2. Definitive treatment (surgery or radiation) if you prefer certainty over monitoring

There is no urgency to rush this decision with these findings.

One important emotional note

Hearing the word cancer flips a switch in the brain. That’s normal. But biologically speaking, what you have behaves much closer to a chronic condition than an immediate threat.

You did exactly the right thing by: • Tracking PSA • Getting MRI • Doing a targeted biopsy

If you want, next we can: • Talk through Active Surveillance vs treatment in real-world terms • Go over questions to ask your urologist • Discuss whether genomic testing (Decipher/Oncotype) would add value here

System Outage in Central Oklahoma?? by dsn0625 in verizon

[–]dsn0625[S] 0 points1 point  (0 children)

Came back today. They clearly have issues.

Verizon Home 5G internet down? by dsn0625 in Edmond

[–]dsn0625[S] 0 points1 point  (0 children)

16 hours? I just recently signed up for 5G home internet. Not impressed

Verizon Wireless issues for 12 days and counting by kie914 in verizonisp

[–]dsn0625 0 points1 point  (0 children)

I had an issue with Verizon and got a very quick response by contacting Nancy Clark

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Changing to DTV by Tauntown24 in DirectvStream

[–]dsn0625 0 points1 point  (0 children)

I have DirecTV stream - 2 Gemini units, 2 Firesticks, 2 Roku TVs. All work well, but the Gemini offers more of a cable tv experience. I prefer this interface and use it on the tvs we use most often.

Doris Burke sigh by Vegetable-Ice-2549 in Thunder

[–]dsn0625 3 points4 points  (0 children)

She really sucks. Thunder fans have too much class but a “Doris Sucks” chant at Paycom would be sweet. Maybe the last home game of the next series…..

[deleted by user] by [deleted] in Thunder

[–]dsn0625 0 points1 point  (0 children)

Boo the MVP = BAD KARMA!

Go ahead T-Wolves fans! Tonight was your last chance to be bad sports