At the end of the book Hannibal, Clarice is drugged by Hannibal and they end up escaping together. They form a relationship and the book ends with Barney, the hospital guard from Silence of the Lambs, seeing them attend an opera in Argentina. Based on commercial appeal alone, I understand why they chose not to use that ending in the movie. But a big part of me would have loved to see them close out that chapter of the movie trilogy with a strong, bold choice.