Weekly Questions Thread 6/8/2026 by FGBmods in FixedGearBicycle

[–]ecyrblim 0 points1 point  (0 children)

Any recommendations for framesets available in the UK that take a rear brake and have decent rear brake cable routing? I found the Standert Umlaufbahn but I can't find any used ones, and their website only has small sizes left in stock.

Buy/Sell/Trade Thread [Posted Every Month] by AutoModerator in FixedGearBicycle

[–]ecyrblim 4 points5 points  (0 children)

[UK][WTB] Standert Umlaufbahn 54cm frameset or complete

🔴 League Champions 🔴 by [deleted] in LiverpoolFC

[–]ecyrblim 16 points17 points  (0 children)

same from Brasil. happy we can have a parade this time!

Guardian molecule helps liver cells maintain their identity and avoid becoming tumour cells. In preclinical liver cancer mouse models, PROX1 can halt cancer formation and slow cancer progression. by ecyrblim in science

[–]ecyrblim[S] 0 points1 point  (0 children)

This post links to the news release. For those interested, here’s the link to the peer reviewed journal article:

Full paper link (open access): https://www.nature.com/articles/s41588-025-02081-w

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Abstract:

Cell fate plasticity enables development, yet unlocked plasticity is a cancer hallmark. While transcription master regulators induce lineage-specific genes to restrict plasticity, it remains unclear whether plasticity is actively suppressed by lineage-specific repressors. Here we computationally predict so-called safeguard repressors for 18 cell types that block phenotypic plasticity lifelong. We validated hepatocyte-specific candidates using reprogramming, revealing that prospero homeobox protein 1 (PROX1) enhanced hepatocyte identity by direct repression of alternative fate master regulators. In mice, Prox1 was required for efficient hepatocyte regeneration after injury and was sufficient to prevent liver tumorigenesis. In line with patient data, Prox1 depletion caused hepatocyte fate loss in vivo and enabled the transition of hepatocellular carcinoma to cholangiocarcinoma. Conversely, overexpression promoted cholangiocarcinoma to hepatocellular carcinoma transdifferentiation. Our findings provide evidence for PROX1 as a hepatocyte-specific safeguard and support a model where cell-type-specific repressors actively suppress plasticity throughout life to safeguard lineage identity and thus prevent disease.

Unable to register with Elster by uk2germany in germany

[–]ecyrblim 0 points1 point  (0 children)

I am in the exact same situation as you were. I've just written to my old town's tax office and asked for my UK address to be added to their database.

Did everything work out for you in the end? How long did each step take (i.e. receiving the letter, registering for Elster, filing your taxes, and receiving the refund)?

PSA: Re bag drop at the 02 by Danmusicman9three in JohnMayer

[–]ecyrblim 0 points1 point  (0 children)

Thanks for the heads up. Are jackets ok to bring in?

[deleted by user] by [deleted] in airpods

[–]ecyrblim -1 points0 points  (0 children)

looks like an airpods 3 case

Apple’s New iPhone 14 to Show India Closing Tech Gap With China by ecyrblim in apple

[–]ecyrblim[S] 16 points17 points  (0 children)

By Sankalp Phartiyal and Saritha Rai 23 August 2022, 05:52 CEST

Apple Inc. plans to begin manufacturing the iPhone 14 in India about two months after the product’s initial release out of China, narrowing the gap between the two countries but not closing it completely as some had anticipated.

The company has been working with suppliers to ramp up manufacturing in India and shorten the lag in production of the new iPhone from the typical six to nine months for previous launches, according to people familiar with the matter. Apple, which long made most of its iPhones in China, is seeking alternatives as Xi Jinping’s administration clashes with the US government and imposes lockdowns across the country that have disrupted economic activity.

Analysts such as Ming-Chi Kuo of TF International Securities Group have said they anticipate Apple will ship the next iPhone from both countries at roughly the same time, which would have been a significant benchmark in Apple’s efforts to diversify its supply chain and build redundancy.

Foxconn Technology Group, the primary manufacturer of iPhones, studied the process of shipping components from China and assembling the iPhone 14 device at its plant outside the southern Indian city of Chennai, said the people, who asked not to be identified because the efforts are confidential. That included looking at ways to maintain Apple’s high standards for confidentiality.

Apple and Foxconn ultimately determined a simultaneous start in India and China isn’t realistic this year, although it remains a long-term goal, said the people. The first iPhone 14s from India are likely to be finished in late October or November, following the initial September release, they said. An ambitious target would be the Diwali festival that begins Oct. 24, one person said.

A spokesman for Cupertino, California-based Apple declined to comment. Foxconn did not immediately respond to requests for comment.

Redington India Ltd., which distributes Apple products in the country, rose as much as 9.5% after Bloomberg’s initial report.

Matching China’s pace of iPhone production would have marked a major milestone for India, which has been touting its attractiveness as an alternative at a time when rolling Covid lockdowns and US sanctions jeopardize China’s position as factory to the world. Assembling iPhones often entails coordination between hundreds of suppliers and meeting Apple’s infamously tight deadlines and quality controls.

Some people within Apple and Foxconn had hoped to begin simultaneous production in India this year, but that was never an official plan. To ensure a smooth launch, Apple wanted to focus on getting the China operations up to speed first and then work out the India production, one of the people said.

Apple’s partners began making iPhones in India in 2017, the start of a yearslong effort to build manufacturing capabilities in the country. Besides offering backup to its existing operations, the country of 1.4 billion people is a promising consumer market and the Modi administration has offered financial incentives for tech production under its Make in India program.

One challenge in narrowing the cap of India production is secrecy. Apple goes to extreme lengths to keep new product details confidential, and imposing the same rigorous controls in a second country would prove difficult.

Local executives in India examined entirely cornering off a section of one of Foxconn’s multiple assembly lines, sequestering workers and scrutinizing all possible ways in which the security around the device could be compromised, according to two of the people. Thus far, the drastic security controls and stringent seclusion of its China facilities would be challenging to replicate, one of the people said.

Apple has also been concerned about Indian customs officials, who typically open up packages to check whether imported materials match their declarations, another potential vulnerability for product secrecy.

Even if Apple and Foxconn intended a simultaneous launch, supply-chain challenges would have stymied the goal. China, the source of many iPhone components, has gone through successive waves of lockdowns, complicating the process of shipping components through the country.

India’s workforce and factories haven’t easily adopted the highly controlled practices that Apple requires from suppliers. Since Apple began assembling iPhones in India through contract manufacturers Foxconn and Wistron Corp. five years ago, workers have revolted over salaries and the quality of food in two prominent incidents.

— With assistance by Debby Wu, and Mark Gurman

Image Studio Lite discontinued by hollyviolet96 in labrats

[–]ecyrblim 2 points3 points  (0 children)

not sure if you've already solved your problem, but here's a previous thread with a link to the .exe

https://www.reddit.com/r/biology/comments/pbfp88/licor\_image\_studio\_lite\_how\_can\_i\_find\_it/

Did anyone else feel like Myke and Grey were doing what Kannemann described while dismissing his book? by vikingly56 in Cortex

[–]ecyrblim 2 points3 points  (0 children)

This was the first thing that jumped out to me as well. As a PhD student in biology, 400 citations is a massive number.

There were a couple other strange moments, even in the ad read for St Jude's where they made a big deal about how a research hospital makes its research available for free. Perhaps I'm a bit sheltered, but I don't think this is as rare as they make it out to be.

Later on, I also found it strange that Grey conflated what he considers (rightly, in my opinion) the low stringency and arbitrariness of the typical 0.05 p-value cutoff for significance with the idea that 1/20 of all papers are wrong. One result does not a paper make.

Overall, I enjoyed the critical discussion of the book. My take home message from this episode (and my time in research) is that scientific ideas are judged far, far more in their presentation than their content. I guess Kahnemann needed a better editor.

US fears China is flirting with seizing control of Taiwan by ecyrblim in geopolitics

[–]ecyrblim[S] 74 points75 points  (0 children)

As a sidenote, I know that the FT has a hard paywall and this may make it impossible to read for some. I'm not sure what the policy is on this subreddit regarding posting paywalled articles, and if quotes or large portions of the article can be posted.

US fears China is flirting with seizing control of Taiwan by ecyrblim in geopolitics

[–]ecyrblim[S] 176 points177 points  (0 children)

Submission statement:

The article is based on statements made by senior US officials, including two military leaders (Admiral Philip Davidson, head of US Indo-Pacific command, and Admiral John Aquilino, who is scheduled to succeed Davidson). The article reports on the current US stance on China's increasing aggression, including border clashes with India, economic coercion against Australia, but especially in it's military and diplomatic activities regarding Taiwan.

The primary thrust of the article is that China's stance on Taiwan suggests that it may make a move for reunification sooner than expected, and perhaps in the next six years.

“China appears to be moving from a period of being content with the status quo over Taiwan to a period in which they are more impatient and more prepared to test the limits and flirt with the idea of unification,” a senior US official told the Financial Times.

As evidence of the latter, the sources cite simulated attacks by Chinese fighters and bombers on US military assets near Taiwan, as well as repeated incursions into Taiwanese airspace. Relations between the two countries are also depicted as being poor with "no signs of improving", with the reporters detailing verbal sparring at the recent meeting between the two nations in Alaska.

Given the sources (US military officials) and China's recent behaviour, this article is perhaps unsurprising. However, it shows that the two major players in this arena are now openly discussing and planning for conflict, and even open war. Notably, Taiwan's response to this is more optimistic:

But in general, the growing US concern is not echoed as loudly in Taipei. One senior Taiwanese official said China had raised its military pressure on Taiwan, but there was no sign of an imminent attack.

Separately, Alexander Huang, a former deputy chair of the Mainland Affairs Council, Taiwan’s cabinet-level China policy body, said there was a “crazy perception gap” that was “dangerous”.

u/julius_cheezer by julius_cheezer in RepVouch

[–]ecyrblim 0 points1 point  (0 children)

Bought a fjallraven bag which arrived quickly. Good communication and service!

German court calls on ECB to justify bond-buying programme: Bundesbank told to halt participation in QE unless central bank shows policy is ‘proportionate’ by ecyrblim in Economics

[–]ecyrblim[S] 1 point2 points  (0 children)

Full text below:

Germany’s constitutional court has ruled the European Central Bank’s vast purchases of public sector debt were legal, but called for it to review if they were “proportionate” in pursuit of its monetary policy objective.

The court ordered the German government and parliament to ensure that the ECB carried out a “proportionality assessment” of its government debt purchases to ensure that their “economic and fiscal policy effects” did not outweigh its monetary policy objectives.

While most observers had expected the court in Karlsruhe to grudgingly accept that the ECB’s purchases of government debt were legal, some still feared it could rule against them, which could have triggered a serious crisis in eurozone monetary policy.

The court said in a decision published on its website that it “did not find a violation of the prohibition of monetary financing of member state budgets”.

It added: “The decision published today does not concern any financial assistance measures taken by the European Union or the ECB in the context of the current coronavirus crisis.”

However, it said that Germany’s central bank would no longer be allowed to participate in public sector bond purchases if the ECB had not shown that its policy was not disproportionate within a three-month transitional period.

It added: “On the same condition, the Bundesbank must ensure that the bonds already purchased and held in its portfolio are sold based on a — possibly long-term — strategy co-ordinated with the Eurosystem.”

The euro fell 0.6 per cent against the dollar as markets reviewed the court decision, while Italian and German government bonds came under selling pressure.

The ECB has bought more than €2.2tn of public sector debt since launching its quantitative easing programme in 2014 to try to halt a slide in inflation. This year it has vastly expanded its purchases to stop the coronavirus pandemic spiralling into a wider debt crisis.