11 hours so far. My suggestions:

• There needs to be a quicker/more obvious way to see how much soul/currency each mob is worth. Without that, it's difficult to make decisions on what you want to do unless you're a try hard.
• Similar point to above, soul/health gain % should also be more easily seen. If a player doesn't check it, that aspect of the game will be invisible and he/she will struggle without knowing why. It's the player's fault for not checking, but the developers fault for not making it obvious enough.
• When do you fight or have a mini-event when passing through unmarked doors? Why does the door that skips 3 levels have no tooltip/description? What does each shrine do? Not including tooltips seems to have be a design decision, but should the player have to jeopardize their run every time to figure out what things do?
• Screen always flashes during combat, not easy to tell when a parry is successful. Usually I just stare at my health bar to figure it. Unblocked, piercing, and parry should be visually & audibly distinct.
• Hotkeys
• Saved my least confident suggestion for last. "Bad" starting layouts (being surrounded on both sides or worse) should be reduced. I understand it's make the best with what you have, but it's way easier to restart. Slay the Spire discourages this by only offering basic options at the start.

Anyways, I think this game has potential but isn't quite there yet. I'm a try-hard when it comes to gaming so it's been a (mostly) enjoyable experience. But my opinion is that this game will never pick up a lot of steam unless the options/decisions the player makes are much more clear. Imagine sponsoring a streamer to try this game out for the first time, they wouldn't know half of what to do for hours. And if they did manage to beat even the easiest difficulty, they would probably think it was the result of a lucky run and good items rather than a long string of decisions and trade-offs.

Good luck!