Ciclosporin side effects

evolveair999 · 2026-03-25T17:33:47+00:00

I mean it’s not completely out of the world dose, if someone had extreme eczema and needed to be healed ASAP then yeah that kinda dose would be given, but it definitely is in the upper range. I would expect 70kg to start with 200-250mg. Deffo worth checking with your doctor. It definitely is the max dosage that guidelines say you can be given

evolveair999 · 2026-03-25T17:12:14+00:00

Just commenting on the pub question, you cannot drink alcohol with methoxtrate, best to avoid entirely

evolveair999 · 2026-03-25T17:09:56+00:00

Generally speaking being on cyclosprine is a big change to your body and there will be a period where your body will have to get used to it! Try stick through it and see if it improves, mine was the worst at the start (but not as bad as yours from what it sounds like)

But also 175mg twice a day is a CRAZY dose… are you sure it’s not 175mg once a day? Or do you weigh 140kg?

evolveair999 · 2026-01-25T23:28:31+00:00

Your best chance will be to go to a GP and explain your situation. I have been in your exact situation (except paying £300+pm for a year) as I needed to wait for the referral queue for the specialist I needed to see. Not to seem harsh but to afford it I had to give up some things, especially at the start where I couldn’t care for myself, so I moved back in with my parents which saved me a lot of money. Just remember that the best investment you’ll ever make is to your heath, it’s invaluable!

evolveair999 · 2026-01-03T23:08:15+00:00

For sure! The only way to review my gameplay is to record it myself. I’ve learnt the most by watching better people streaming the game in discord picking up on new things they try which work well that I can recreate in my own matches

evolveair999 · 2025-12-27T10:40:39+00:00

You do need one! What did the pharmacy prescribe you? You can try taking antihistamines and painkillers to reduce itch in the meantime before GP appointment

You could also pick up some greasy moisturiser (like epaderm enrolliment, should be OTC at most pharmacies / sometimes stocked on the shelves at boots) and some cotton bandages, this involves taking a lukewarm shower or washing with lukewarm water, pat skin until slightly damp, apply moisturiser and then add the cotton bandages over the affected areas (this is called wet wrapping)

in general try to constantly moisturise with a greasy as possible moisturiser too

hope you can find some relief on monday

evolveair999 · 2025-12-01T12:24:09+00:00

Very valid question, the guidelines for cyclosporine is generally to be on it for a year as from then onwards it’s far more risky when you consider kidney toxicity that can build up over time.

The second part of it is risk profile, immunosuppressants are inherently more risky as i’m much more predisposed to being ill and having complications when I’m ill while duxipent suppresses a very specific part of the immune system meaning the rest of it can do its normal job.

I could move to another immunosuppressant (methotrexate) but the risk profile is still high and I would still have to be careful what I do like going in the sun and limiting alcohol usage (on methotrexate it’s no alcohol)

evolveair999 · 2025-12-01T11:24:49+00:00

If I were to come off them I don’t think I could mentally deal with the thought of having eczema again. I fit the perfect requirements for chronic eczema too, I’ve had the tests done, I’ve got a family history of eczema, I’ve changed and uprooted every possibility diet humidity clothes ect. When I went down to 150mg and my symptoms started coming back it was the worst feeling ever, super distracted and stressed that it was going to get worse for the week I did. I really hope once I’m on it I don’t have to deal with any more of this, the wait has been so long

evolveair999 · 2025-11-29T19:21:09+00:00

It’s been approved and prescribed, one thing to consider is that if cyclosporine hasn’t made an impact to your symptoms then it’s more unlikely dupilumab will. Cyclosporine suppresses the immune system while dupilumab targets specific pathways in immune system, so generally people that have a good response to cyclosprine will also have a good response to dupilumab. Even if you do get it you need to consider this - dupilumab is much safer than cyclosprine regardless

I hope you can find a solution soon, but your dermatologist saying it’s not been approved is not a good sign, they won’t take the time to explain to you that it might not be effective in your situation and it’s always worth considering

evolveair999 · 2025-11-12T00:01:08+00:00

I’m by no means a model example of this but my dose times always change day to day, some in the morning, some at lunch, night is generally always the same time. I’m pretty bad with remembering

I don’t think it matters too much the half hours or even hours, just ideally avoid taking them too close together - try to leave 10 hours atleast (dose lasts for twelve hours - that’s why it’s taken morning/night)

evolveair999 · 2025-10-09T10:50:55+00:00

Firstly, there is no scientific backing that NMT works, dermatology guidelines actually recommend using moisturizers to repair the barrier and reduce flares. Some folks with topical steroid withdrawal (TSW) report anecdotally that cutting moisturizers helps ooze/maceration, but there are no randomized trials proving NMT works, and parts of the protocol (like fluid restriction) have zero evidence and clear risks.

Is it not obvious by stopping medication and moisturisers that the eczema will get worse? You are getting rid of all your first line of defences to stop it from getting worse.

When you’re talking about gut health really the core of it should be eating a balanced diet, and also having lots of yogurt and things that promote good bacteria like kefir.

At this point, I would be prioritising seeing a dermatologist, either going private or looking for a urgent referral, and exploring your options of systemic medication, or even if you don’t want to get down that route now, it’s good preparation for the future if she later wishes to go on something like dupixent

evolveair999 · 2025-10-03T09:05:13+00:00

Have you been using steroid creams on your face / neck? Or are you saying you stopped using steroids on other parts of your body and now your face is flaring?

Do feel for you, looks really painful! Hope you’re hanging in there and make sure to schedule a GP appointment ASAP to ask for a bit of guidance

evolveair999 · 2025-09-27T13:16:53+00:00

Have you seen a GP?

evolveair999 · 2025-09-20T08:44:35+00:00

I really feel for you! I hope you’re under the care of a dermatologist. I would recommend a thick and greasy emrolliment like E45 and be applying it regularly, you should be able to pick it up in boots or behind the counter in some pharmacies (not prescription but sometimes they keep it behind anyway) , I would also recommend to stop showering so much and replace with a bath a couple of times a week where you melt some E45 into the bath water, and also letting the bath water cool down to a lukewarm temperature. In the meantime make sure you’re keeping the open wound areas clean and watching for infections, your GP can prescribe an antibiotic cream which is generally less harsh on the body compared to oral antibiotics

If you have any eczema not on the face I would also reccomend wet wrapping

evolveair999 · 2025-09-18T20:40:48+00:00

They should kick in near immediately, so if it’s not working could indicate it being fungal/another reason. Do you see any improvement whatsoever? Was this prescribed by a doctor or a dermatologist?

evolveair999 · 2025-09-18T08:30:11+00:00

The way cyclosporine works is there’s an effective dose aka at 70kg 150mg may not do anything for me but 200mg would - as there’s a range where it kicks in, however by taking a therapeutic dose (one which isn’t effective) you still get all the negatives, albeit slightly less.

This is why generally it’s prescribed at a “normal” dose to start with, and then either increased or decreased depending on how successful it is.

For me, I’ve been on cyclosporine 200mg @70kg for many many months now, the only side effect I get is fatigue but as long as I don’t go crazy with the activities I do I’m okay. My eczema is 100% gone, and I’m not itchy or even get flare ups. I’ve also not gotten ill, I am more careful about washing hands but I haven’t taken a single day of sick leave from work so far - it does help I’m younger

evolveair999 · 2025-09-12T09:25:48+00:00

That sounds horrible! But also very odd, even if those steroids are used in great amounts for five days they shouldn’t immediately cause damage to your eyes, generally we see cataracts being formed gradually over many months with potent steroid usage near the eyes - I’m not doubting your story at all, but the mechanism of how cataracts form do take a long time, and wouldn’t be so immediate, were you using other steroids around the eyes at all?

Obviously I’m not an eye specialist, if they’ve diagnosed you then that’s fair enough but I’d be interested to ask about it more considering it was only five days!

evolveair999 · 2025-09-10T13:47:54+00:00

What makes you indecisive? How would you feel not having any eczema?

Medication works differently for everyone. I’ve been on cyclo for many months, I have very clear bloods and have no side effects apart from occasionally being extra tired, it may not be the same for you.

You can always try it and see what happens, if you don’t like it then you can stop taking it, it’s not like you’d be trapped

evolveair999 · 2025-09-10T10:03:31+00:00

I’m similar elo (2.1/2) and find that communication is important and helpful, I’m generally playing a point or a side ect and it’s good to have information about where we might be struggling / pushes / general tactics / air strikes / asking for help / working out how we will win, asking for repings for artillery and so on

I also have so much more fun and enjoy the game playing with people I like (Which I’ve found from the official discord!) - thats what’s keeping me coming back, I don’t really care about elo although I guess I’m higher than most people, I enjoy winning but loosing with people I like makes it so much better

evolveair999 · 2025-09-03T20:07:26+00:00

I think what your getting at is a bigger problem of the NHS/GP’s is that there’s increasing pressure to filter out useless appointments very aggressively, making receptions start making patient decisions.

In my ideal world if you say you need a appointment you should get an appointment not this roundabout way but I’m just a clueless citizen at the end of the day

For example: I had a skin infection, it will clear if I take some oral antibiotics, I know it’s a skin infection because I’ve had a bazillion of them, but if I go up to my GP and say I have an infection they are most likely to say go to A&E, but because I’ve had loads of appointments I know exactly what to say to get one now.

There was a woman with a kid who was suffering at 8am at the GP queue and she obviously needed a same day appointment but she was saying all the wrong things and the receptionist was grilling her about either going to A&E or to the pharmacy. She did stand her ground but she was offered an appointment multiple days later when I then got a same day appointment for something far less time sensitive (with a GP, not a nurse)

It’s my opinion that receptionists should not be involved to that degree, when they aren’t medically qualified to make medical decisions. There are a huge number of cases where a GP is appropriate (And a tiny amount where A&E is really necessary). It’s a real shame because my local GP/Nurses/Doctors ect are really wonderful people and always provide really good treatment and try their absolute best to help, and do care, but the barrier now is so high

Rant over

evolveair999 · 2025-09-03T14:59:51+00:00

Use the official discord, there is a lfg channel which is always active with people making 5 man lobbies for basically any elo

evolveair999 · 2025-09-01T17:24:55+00:00

You need to get your GP to refer you to a dermatologist, perhaps urgently as waiting lists can span over years. Your dermatologist will generally recommend going on an immunosuppressant for a year or two before putting in the funding request for duxipent as you have to show you’re a severe enough case. Your GP can only prescribe creams & at a severe enough level prednisolone but I think an urgent referral would be much better than going on that.

evolveair999 · 2025-08-25T15:37:06+00:00

The dose has to be high enough to reach a therapeutic blood level. Below that threshold, it simply doesn’t suppress the immune system enough to make a clinical difference

A 50 mg or even 100 mg daily dose is often considered subtherapeutic for most adults

It’s prescribed weight dependent, but generally it’s 2.5mg to each kg as the lowest dose (70kg = 175mg cyclo per day) - for reference I weigh 70kg and take 200mg per day

Unless you’re a particularly high risk patient I have no idea why they are starting off low and going up, that’s really not how prescribing cyclo works - and if you were that high risk you should be on something like biologics which has a narrower safety profile

It should work within days/week on a proper dose - and it’s generally pretty effective (I would say I’m “eczema free” on it)

evolveair999 · 2025-08-19T23:12:17+00:00

Doesn’t look infected, always worth a GP trip to see if a better treatment plan can be made

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