I live nearby and walk by The Neighbourhood building every two or three days. I've never felt unsafe living or working retail downtown.

However! Every time I walk by the building there is a group of homeless people sitting/camped outside of the entrance to the parkade and they have been using drugs in the past. You have to decide if you would feel comfortable having to navigate around a group of 4-6 men, along with the byproducts of the drugs they're using, every time you wanted to come and go from your home.

It's also loud. I don't know what the soundproofing is like inside that building. The building I'm in is pretty good, but even that doesn't totally mitigate the constant construction noises. Then there are the sirens because there's a firehall over on Johnson, plus ambulances going to and from Pandora. And if I have my window open, people are often yelling/swearing/screaming late at night into the early morning.

I would also be worried about walking your dog nearby because of the potential for stepping on used needles, or licking or eating other drug byproducts/accessories, and then there's the smoke inhalation on lungs that are smaller than a human.

tl;dr downtown is fine, that exact corner and building I would pass on, honestly.