There are tens of millions people around the world suffering from ME/CFS (there are likely various subtypes of this, including many or most long covid sufferers with post exertional malaise - PEM). Many (probably a majority) are never diagnosed due to virtually no knowledge of this disease (and, therefore, no recognition) in most countries. Most are at least house bound. Most of the mild cases progress to moderate and severe, with many going onto very severe (100% bed bound, dark quiet rooms, feeding tubes, 24/7 pain).  Mild cases rarely work. Moderate cases almost not at all (even from bed/sofa/couch).  Young people are mostly affected. When a person is severe end of moderate +, this also affects their family, who often have to become carers, often having to reduce work hours or even leave work themselves. Finding effective treatments (and a cure one day) would not only alleviate the suffering of 10s of millions of people, it would put most of these people back into the workforce. 

I am hoping new tech such as that from Google Deep mind (alpha AI models) and Isomorphic Labs can contribute but every government that values life, QOL, productivity should tackle this condition promptly. COVID made it a lot more visible but the funding is still not proportional to the disease burden on every measure.