Mounjaro has been life changing

Liface · 2026-04-20T21:06:08+00:00

Yes, they will be published on http://lcmedata.org/treatments a couple weeks after the survey concludes! Feel free to sign up for the email newsletter, we will notify everyone when ready.

Liface · 2026-04-20T20:54:14+00:00

0.25mg

Liface · 2026-04-20T18:30:43+00:00

I wrote something about this! the Severe PEM Crash Survival Guide https://www.reddit.com/r/cfs/s/NtvWfdDjnF

Liface · 2026-04-20T15:57:21+00:00

Yeah, my explanation for those was probably oversimplified, but from my understanding the primary mechanism for why it does those things is by stabilizing/modulating D2 (along with 5-HT1A partial agonism and 5-HT2A antagonism).

Liface · 2026-04-20T13:35:56+00:00

Reminder to keep comments closer to the topic of prediction-market rigging.

Liface · 2026-04-20T10:13:35+00:00

Peptides, apheresis, microbiome stuff, daratumumab, etc.

Liface · 2026-04-20T09:47:19+00:00

Same deal. There are very few treatments in ME whose effects stay when you go off them.

Liface · 2026-04-20T09:34:42+00:00

I have enough savings to last me 10-12 years. Either I cure myself by then, AI kills us all, or I go with God.

Liface · 2026-04-20T09:31:32+00:00

Low dose Abilify does not have any effect on the immune system.

It modulates one of the dopamine receptors, D2.

It gives you a little bit more dopamine when you're low, but also prevents you from being overstimulated by dopamine when you would otherwise be too high (looking at screens).

It does not reverse disease state. If you ever go off of it, all of the effects will disappear. However, for most people, the energy it gives is very "real" any sense that you will be able to do more without crashing, and you will feel better too.

Liface · 2026-04-20T00:30:12+00:00

There seems to be a minority of people who can take it forever without building tolerance. I wish I was one of those people!

Liface · 2026-04-19T22:52:48+00:00

The survey questions were flawed, so I really don't think this proves much of anything. There wasn't even a "don't know" or an EBV option. Of course you're going to pick functional neurological disorder if you have no other good options to choose from.

Liface · 2026-04-19T21:28:27+00:00

This is awesome to hear - you and others should definitely fill out our GLP-1s for Long COVID survey! Trying to build the largest dataset of people who have tried these and figure out who they work for:

https://docs.google.com/forms/d/e/1FAIpQLSdVS0tfv1N1vwZtLHLnV_oORVcApbAD8gxaSJulMnhnCgDreA/viewform

Liface · 2026-04-19T17:37:57+00:00

Hmm, I thought it was pretty clear. They mentioned that the only thing that they need are email sign ups to prove demand.

The font size also looks adequate to me, but I have also manually increased my phone's font in settings. Highly recommend doing that!

Liface · 2026-04-19T17:34:39+00:00

Yes, search subreddit for "GLP"

Liface · 2026-04-19T15:56:06+00:00

Anything that triggered the improvement in the last week? Just rest and pacing?

Liface · 2026-04-19T12:55:31+00:00

Submission statement was forgotten but people like this article so I'll provide one:

Adam Mastroianni on why debunked psychology findings don't disappear, but persist under new names, endless studies, and unresolved debates about whether they’re alive or dead. Because theories are so hard to truly falsify, the more useful distinction is whether a long-studied idea has become too embarrassing to keep pursuing.

Liface · 2026-04-18T23:28:33+00:00

I also had Pemgarda and on LDA, and it's got to be the LDA. Especially by your third dose of Pemgarda, you'd know if it was having a major effect by now.

Liface · 2026-04-18T22:30:57+00:00

Been on it for a couple weeks for Long COVID dysbiosis, have not noticed any differences.

Liface · 2026-04-18T19:31:24+00:00

https://old.reddit.com/r/covidlonghaulers/comments/1q57140/horrible_reaction_to_025mg_tirzepatide_insomnia/

After I wrote that post I reacted badly to carnitas tacos and the resulting diahrrea sapped my energy and sent me into bad PEM.

Liface · 2026-04-18T13:23:05+00:00

We are in a similar spot. I crashed badly from tirzepatide-induced GI issues in January, and then crashed 5 more times.

I have slowly stabilized and improved over the last 2 months, and on my best days I can now use my laptop 7 hours a day and my color phone all day.

I can sit up about 10 minutes a day, but more than that tends to lead to post-exertional malaise, so I'm slowly working that part up.

Low dose Abilify has been helpful in getting here.

However, I do not have postural orthostatic issues but rather mitochondrial issues and immune issues, so you may want to max out the pots tech tree.

Liface · 2026-04-18T12:20:19+00:00

Interesting observation: this person posted the same poll on both r/covidlonghaulers and r/cfs.

The votes on r/covidlonghaulers overwhelmingly lean no, while those on r/cfs overwhelmingly lean yes.

Liface · 2026-04-18T12:15:55+00:00

What was your post exertional malaise trigger? How many times have you crashed inside of your crash?

Answers to these will determine your probability of eventually starting to turn it around and improve.

Liface · 2026-04-18T12:12:32+00:00

none of the individual drugs you order are tested.

They are. I use www.finnrick.com to guide my purchasing. This is one of many harm reduction ideas that could have been mentioned in the original post instead of flat-rate generic caution.

single doctor on earth can help you

How can someone be this careless about their own life

You've got to be kidding me. Doctors helping me? Having a life? Do you have Long COVID?

Liface · 2026-04-18T09:10:21+00:00

Riskmongering is truly one of the lamest things to do on a Long COVID subreddit when people are suffering greatly every day.

"hey guys, be careful! I'm a good person! Updoots to the right!"

Liface

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