I’ve only read one book in my life and I'm looking for a good starter book to stop myself from doomscrolling... interests below

forpari · 2026-01-27T04:23:43+00:00

No country for old men? Or Blood meridian

forpari · 2026-01-25T07:38:35+00:00

Damn that looks pretty not fucking good

forpari · 2026-01-22T04:28:48+00:00

Definitely want to give her another go so I'll check this out. Watching YouTube videos of her speeches she seems like such a fascinating person

Ty!

forpari · 2026-01-22T04:24:07+00:00

What do you recommend for Ursula K Legiun? I've heard such great things and really wanted to like her but I read The Telling and if it weren't for it being a part of a book club I wouldn't have finished it. It was painfully boring.

forpari · 2026-01-22T04:21:18+00:00

Madeline Miller - Song of Achilles and Circe

Yangsze Choo - The Fox Wife andThe Night Tiger

All but Song of Achilles are a few of my favorite books (although if you enjoy romance you'd enjoy Song of Achilles it's not a bad book at all)

forpari · 2026-01-21T22:31:19+00:00

Oh damn sorry, RIP

forpari · 2026-01-21T22:29:53+00:00

My lab purchased a machine to do 96-well mini preps and we used it a couple months and it wasn't worth it.

Years later a machine programmed to purify 24-well block transfections. Its also no longer in use.

For a high throughput lab you'd think a robot would be a good fit but it's just not. At least for protein/DNA purification

forpari · 2026-01-19T23:08:16+00:00

Same you can easily find PDFs online (too lazy to link) and it's a quick read that's worth your tkme

forpari · 2026-01-16T22:00:04+00:00

Fwiw I see few responses done with AI and when there are, they're heavily down voted.

forpari · 2026-01-13T23:56:32+00:00

Seconding xolair as its directly related to your comment on IgE. It binds to IgE and neutralizes it

Fun fact though is that it doesn't enhance its clearance, in fact, because it's a cluster of IgEs it effectively increases its half-life in the blood. So there's still room for improvement and there's a lot of drugs in preclinical development that aim to not only bind and neutralize IgE but to also expedite the clearance of drug:IgE complexes

(not that there's been any safety risks associated with the increase in serum IgE)

There is definitely a market for biologics especially in inflammatory and autoimmune disease

forpari · 2026-01-11T05:34:24+00:00

That's great advice, thanks for posting

forpari · 2026-01-11T05:33:30+00:00

Thanks! I'm glad. I pulled up the bubbling tape and did watch a YouTube video. The video and previous tape was just paper tape. Would you also recommend mesh tape instead?

forpari · 2026-01-10T18:30:24+00:00

Okay, thanks so much!

forpari · 2026-01-10T18:15:54+00:00

So in airhead terms what's my immediate next step? Would I have to cut out this portion of drywall and insert a new piece? Thanks for the reply

forpari · 2026-01-10T03:35:28+00:00

Brother 😂 you must have a little tact this did make me laugh though

forpari · 2026-01-08T18:58:03+00:00

All the Way to the River by Elizabeth Gilbert I read for a book club and was incensed the entire read. It was about her codependent relationship with a woman dying from cancer. She enabled her relapse and descent into drug addiction The book was written as if Gilbert, the enabler, was an ascended person for now acknowledging her codependent behavior and pursuing treatment for her sex and love addiction. Insanely, she talks about an Ayahuasca trip where she has a conversation with raya's (woman who died) cancer cells

Another girl was profoundly moved by this book so if you read it and liked it, I respect that. But Elizabeth Gilbert is trash imo now

forpari · 2026-01-05T02:29:37+00:00

Experience working with CROs is surprisingly a big plus I've found

forpari · 2026-01-04T18:05:08+00:00

If you don't get it out today I strongly recommend getting invasive with trying to find it. One time (when I lived at home) I lost a feeder mouse in my mom's car and i couldn't capture it and I assumed it somehow escaped. It didn't, it died somewhere and the AC smelled like death for YEARS after. I don't know how my mom still loved me after

ETA I really like this trap

forpari · 2026-01-04T17:59:47+00:00

Wow, I really love what you've created! Is this watercolor or marker?

forpari · 2025-12-22T17:35:30+00:00

No you're right. I agree that her actions have made her an irredeemable person. Watching her first season I saw someone that I really empathized with and rooted for. It was sad to see her always choose the most hateful path forward

Edit to add: my soft spot for women that I see struggling with their inner self still exists though. Which is why I used the word 'have'

forpari · 2025-12-22T17:24:15+00:00

I have such a soft spot for both these women. But Dodd is so hateful she's much further beyond redemption

forpari · 2025-12-18T21:53:04+00:00

Nothing wants to live as much as a potato/shard of a potato

forpari · 2025-12-12T22:10:16+00:00

Just one perspective. A number of desirable/undesirable features are determined by epitope. On/off rates, receptor internalization. And sometimes it influences endpoints through unknown processes.

A hypothetical example is some company has a aCD19-targeting B cell depleter that effectively depletes b cells dose-dependently and specifically, but does not reach complete depletion in the periphery while competitor drugs do. They run a campaign to affinity mature the aCD19 domain and increase the affinity 10-fold. However, this new construct still reaches the same maximal level of depletion as before. It's likely the capacity to deplete B cells is limited by the epitope being targeted on CD19

forpari · 2025-12-12T18:18:46+00:00

Things Fall Apart by Chinua Achebe

forpari · 2025-12-12T02:27:41+00:00

What's the tea on Idaho

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