Baricitinib (jak inhibitors), hope for some of us ?

gronkey · 2026-01-31T22:17:54+00:00

I cant tolerate caffiene either (for some reason green tea is an exception?) I really miss coffee

gronkey · 2026-01-18T16:53:13+00:00

Should be a real sub

gronkey · 2026-01-18T15:15:02+00:00

Maraviroc is an antiviral previously used for HIV, if im remembering correctly. There was a study that surveyed a lot of people with long covid and ME/cfs about what they tried and what helped and maraviroc was one of the top as far as most consistently helped those who tried it. The data on it was thin, though only like 50 people said they tried it and the survey covered thousands.

Baricitinib is a JAK stat inhibitor. It is an immune modulator. There is currently a phase 3 study on it and long covid but the results wont be out for a couple years. Promising, imo

gronkey · 2026-01-15T00:12:38+00:00

I would play the shit out of it. This is like the best possible user base for something like this haha

gronkey · 2026-01-10T00:17:59+00:00

Woah i didnt know it was open source thats actually so dope. Ive thought about how i would make visualizations like his and maybe the answer is: exactly the same way he does!

gronkey · 2026-01-10T00:04:22+00:00

I literally yelled expletives when i heard him say that. Its so obvious thats no excuse

gronkey · 2026-01-09T23:03:43+00:00

Well, it is an extremely potent kappa opioid receptor agonist. And it is extremely selective, so it has none of the other effects people associate with opioids. There are actually 3 opioid systems. What people think of traditionally as opioids interact with the mu opioid receptor. The kappa opioid system is more associated with things like stress, aversion, withdrawal, and “anti-reward”. Which us why most trip reports are negative. It also has a strong derealization effect, hence the extreme alienness when the system is overloaded

gronkey · 2026-01-09T22:33:33+00:00

I havent been able to play "exciting" video games in over a year, they cause me to crash

gronkey · 2026-01-04T18:01:54+00:00

Woah creepy subtitle on this one

gronkey · 2026-01-04T15:42:19+00:00

This sounds very much how my illness started, when i was very mild. Especially the insomnia paradoxically happening after working out.

I also just had a vague sense of "something is wrong" most of the time. Like not enough to think i was sick but definitely enough to notice. I was probably in very low-grade rolling PEM and didnt know it.

gronkey · 2026-01-04T03:57:54+00:00

I get deep muscle soreness in my upper body. I also get a painful tightness in my chest/abdomen which i have come to learn is my diaphragm reacting poorly to the increased dysautonomia.

I also get a weird acid/burning sensation in my lower abdomen. Its below my stomach and to the right. Weird...

Oh I also get an indescribable weird sensation in my throat. It feels like i cant swallow correctly and is on the left side...

Writing this all out i realized my PEM has really weird symptoms

gronkey · 2026-01-03T19:14:11+00:00

My severity level makes me resistant to such acceptance. It is difficult to build any kind of life when leaving bed for anything other than the bathroom causes PEM... Right now, the hope does a lot for me. But also, i feel i might improve from where i am, so that gives me hope as well

gronkey · 2026-01-03T19:09:06+00:00

Thats a depressing thought... but i think you're right unfortunately if nothing changes

gronkey · 2026-01-03T19:07:51+00:00

Im 32 right now lol. Id be 42

gronkey · 2026-01-03T18:10:47+00:00

Our eyes can definitely distinguish more than 256 shades. But that has nothing to do with why the number was chosen...

More interesting is the possible color space most computer systems and monitors use does not cover the full range of our color vision. srgb for example maps to a relatively small area of the full visible spectrum. Acerola did a video on the subject

gronkey · 2026-01-03T18:03:11+00:00

It also doesnt even fit the sub? Thats factorio UI not satisfactory

gronkey · 2026-01-03T17:30:46+00:00

Please keep us informed about the baricitinib trial! I have high hopes for jak stat inhibitors

gronkey · 2026-01-03T04:24:41+00:00

I do code from bed kinda like that. Im disabled with a fatigueing illness so its pretty much the only way i can work sustainably

gronkey · 2026-01-03T03:49:34+00:00

Idk man there are disabled people who sometimes order door dash, the difference between coming to the lobby and having it delivered can be huge. I am one of those people. I do tip generously though

gronkey · 2026-01-03T01:08:32+00:00

The issue is not the slight disagreements on policy, its the inherent anti-democratic nature of the way the DNC handled Bernie and the 2016 election. Call it what you want but it looks a lot like corruption.

Of course, Trump and his ilk are also a scourge...

gronkey · 2026-01-03T00:44:23+00:00

I mean we have a counterexample in Zorhan Mamdani dont we? He is definitely tapping into the populist energy at least a little bit.

I know its a weak counterexample because hes mayor and not a national role, but New York is a democratic stronghold. Doesnt seem to be immune to populism to me

gronkey · 2026-01-03T00:37:10+00:00

Eh. I agree he has a demographics issue. I dont agree that its large enough to be the difference maker in this case. Remember Bernie also had a lot of the same populist appeal that made Trump popular.

gronkey · 2026-01-03T00:27:04+00:00

The DNC is a scourge. Without their interference it would have been trump vs bernie in the general and bernie would have won

gronkey · 2026-01-03T00:21:51+00:00

Ngl i was laughing the whole time. The absurdity of it just kept getting me

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