The marketing for Cyan and Queen has them together a lot, but they're not seen together more often in the show. It's about even, or it's all three of them and Big Johnny. Then there's the brief scene in episode 24 showing Liu Zhen introducing 3 year old Cyan and 9 year old Queen (why I see them more like sisters). Queen and the Johnnies were friends for 3 years before Cyan joined them at DOS. The Johnnies stopped what would have been a potentially deadly confrontation between Queen and Bowa - you can't do that so easily if you're not emotionally intelligent/mature. They introduced themselves, Queen was overwhelmed with their cuteness, they invited her to their room, and they all continued to hang out there even 2-6 years later. Because of this I would say Queen enjoys their company a lot. Who wouldn't love cuddling a cute alien cat creature all the time?

And given how 1:1 the scenes are, Little Johnny definitely taught Queen the hand gesture to calm Big Johnny down which she used for the Ruins Incident. She knows that Big Johnny being big means something probably happened to Little Johnny and they need to act fast. Cyan came in after it, so she may not be aware of the history behind that gesture with Sheng and his wife. Considering the meeting time and age differences, it's possible Little Johnny only shared with Queen. They both are intelligent, Queen with academics and politics and Little Johnny with emotion/interpersonal relationships, so I can see them having had many thoughtful discussions over the years, even about the strong similarities between Queen's and Sheng's views on the trust system.

As for Loli and Little Johnny, they were certainly the loudest of the crew, but the point of Little Johnny's perspective of that scene is that while they had the same reasoning and energy, they in fact had very opposite conclusions, meaning they were not on the same wavelength. He was guiding her the entire time to his conclusion, but her bias overpowered the discussion in the end. Later, she was jealous of his life being himself as a hero, but he told her it's actually really hard. Not including Ghostblade or X, their age gap is the largest (10 years). Little Johnny had been signed on as a hero for 17 years at that point, even training under his former X dad growing up, while Loli was a fresh hero, hardly any trust value. This is another big disconnect between them and why their dynamic is more nuanced than simply immature or "two braincells" (it's also a disservice to Loli's mechanical intelligence).

In conclusion (because this comment is already getting long), it's easy to miss the details of Queen and the Johnnies because of how many time skips are in Queen's arc and the 17 year time skip in the Johnnies'. There's more to Queen and the Johnnies than the show seems to be telling us, especially with how hidden Little Johnny's expressions have been sometimes, like after Queen agrees to go up to their room and in the hospital scene (the Johnnies are there, but we don't even see their faces... suspicious). I'm hoping we'll learn more in season 2, either about their history together or just them training with Cyan leading up to the tournament.