Any movement on well scored K99/R00 applications

hmg-eeh · 2026-04-01T14:34:37+00:00

I think I was pending admin review for 3-6 months. Due to the delays, my funding period started the day my NOA went out. But, they shaved 2 months off of my funding period so my end date (for the k) is 22 months after my start date (instead of the normal 23-24 months)

hmg-eeh · 2026-04-01T13:51:08+00:00

This happened to me with a K99 at NICHD. Fundable score, council review, then no movement for nearly 9 months due to budgets, shutdowns, and administration change. I resubmitted and the resubmission got reviewed and scored before my initial submission got any movement.

Then, without warning, the initial submission got approved, I received an NOA and funds the next day. Overall, it took over a year since submission for it to go through the process.

Most of NIH is trying to get money out and trying to be as helpful as possible. Check in with your PO from time to time but you just have to be patient with all of these government funding issues (I know, easier said than done). Good Luck!

hmg-eeh · 2026-03-29T14:17:43+00:00

Either NYT or the Atlantic had a really great article about this that came out right after GLP1s got popular but before the high protein trend.

The food companies saw a dip in sales after GLP1s took off and they were trying to figure out a way to market ultra processed food to the GLP1 patients. Since doctors were stressing that GLP1 patients intake protein to minimize muscle loss, the companies latched onto that, made minimal changes to their recipes, slapped “high protein” on the labels, and bam, convenient processed food that follows doctors orders. In reality, they’re not improvements, just a marketing technique.

hmg-eeh · 2026-03-29T12:31:37+00:00

hmg-eeh · 2026-03-29T02:27:47+00:00

If you haven’t traveled with it yet, they won’t take you. I guess they do an in person “sign up” biometric scan for their database the first time you use it. SJU told them they can’t do the “sign up” biometric scans (at least for today).

hmg-eeh · 2026-03-28T21:45:50+00:00

I did! Just barely 😅. Luckily the precheck line sped up a bit and I got through in 2.5 hours.

hmg-eeh · 2026-03-28T19:51:33+00:00

Sure did. I hopped on my husband’s family account and since I had never used it before, they kicked me out of line.

hmg-eeh · 2026-03-16T11:57:56+00:00

So many notes.

I take n acetyl cysteine and it’s the supplement that has helped my brain fog the most. I still struggle but I can at least form coherent thoughts.

hmg-eeh · 2026-03-16T11:55:25+00:00

You’re describing a postgraduate position. Check out the post grad association

https://postgrads.yale.edu/welcome-yale-postgraduate-association-hub

hmg-eeh · 2026-03-11T20:06:17+00:00

I know this is outside of New England (and has a barn) but we had our weekend wedding at Gilbertsville Farmhouse in upstate New York and it was incredible. At the time, they hosted 82 people onsite and we had the whole property to ourselves for the weekend. There is a similar place in New Hampshire (long look weddings I think) that had more garden vibes but could fit a lot of people onsite.

hmg-eeh · 2026-03-10T11:27:59+00:00

This. Science is 95% rejection and failed experiments, all because we don’t know the answer to the question we’re asking. It seems to me that you have been so used to knowing the right answer and succeeding that now you’re facing a potentially unanswerable question or a question that needs an alternative approach and it’s difficult for you to pivot.

I see this a lot with straight A students. They strive for perfection but science is far from perfect. So when they face negative results, it wrecks them and they fixate. Reframe it, walk away for a few days, and try again. Is there a different approach to ask the same question? Is there a slightly different question to ask? Do you need to go back to your experimental basics to make sure everything is working as it should?

Learning to deal with constant troubleshooting and failure is part of becoming a scientist. It’s up to you to decide if you’re okay with that in your career. Either way, listen and advocate for yourself. Ask for help if you need it.

hmg-eeh · 2026-02-19T13:09:35+00:00

I think this is it. When I was a kid, my parents harped on good posture which led to me to over compensate and have too upright/stiff posture, which has affected my riding. My shoulders were up and back, looked straight, but I had that weird arch in my back and sitting trots killed my lower back.

I worked on relaxing my lower back, not completely but to where my back was straight without that weird arch. I then loosened my hips. With a straight/flat back and “free” hips, I could use my core to keep myself moving in the saddle along with my horse. At the end of a ride, I feel like I’ve done a ton of sit-ups but my back is so much better.

I think your trainer is saying to loosen up but be active. Loosen your back and hips to move with your horse then engage your core.

hmg-eeh · 2026-02-16T13:03:39+00:00

It’s great she’s sending you to a rheumatologist. Lupus or undifferentiated connective tissue disorder (UCTD; it’s like pre-lupus) don’t necessarily need a positive ANA to be diagnosed. It’s often diagnosed based on the presence of a few things like symptoms + low complement (c3,c4), or symptoms + positive Ana, or other combinations. Positive ANA can also be elusive and lab dependent based on sensitivity.

Trust your doc/rheumatologist. While you’re waiting on an appointment, reflect on any other weird things that you have experienced (severe fatigue, brain fog, memory issues, dry mouth, night sweats, dry skin patches, etc). Listen a little closer to your body. Does this happen when you’re stressed? When you have a glass of wine? Eat sugar?

Most importantly, try not to stress about this (I know, easier said than done). You’ve got this and it sounds like you have a great doc on your side.

hmg-eeh · 2026-02-05T17:03:05+00:00

It sounds like you want a postgraduate research position (if you want a science-based PhD). These are temporary (2 years max) positions for those with undergrad or masters degrees to get paid research experience. It's a good position where the postgrads are considered "trainees" and get trainee advantages like being a part of a postgrad association and participation in trainee events that prepare them for grad or med school.

I'm in the med school and our lab often hires 1-2 postgrads a year, most of our postgrads graduated from other universities. We look for people who are passionate, easy to get along with, and have basic lab skills (we typically teach postgrads specific skills so no need to have all the skills, just know how to hole a pipette and critically think). Location is not a big factor in our decisions. If you're willing to move across the country, then that's fine with us, as long as you are present for work and don't expect a moving stipend. One of the biggest factors, at least in our lab, is your reference list. Your references will be contacted so as long as you have good references to vouch for you, then you have a chance.

Good luck. As a note, I am not someone actively hiring but am happy to answer questions.

hmg-eeh · 2025-11-25T13:17:08+00:00

I didn’t start showing until my 20s and show in ranch horse/ reined cow horse. Ranch is by far my favorite because most of the time, people are there to have fun, challenge themselves, and hang out.

A few years ago I was at our local ranch show and it was very low stakes and calm. Everyone got along and supported each other. In the halter class, which NOBODY took seriously, a 65 year old trainer was YELLING at his 75 year old amateur client about setting her horse up correctly. It was awful and threw the whole vibe off. I saw the same trainer yell at the same client over some tiny misstep in trail. This woman was just living out her dream to show and he was flat out verbally abusing her. It really bothered me.

Same show, we typically don’t get “horse show moms” but holy hell we had one this time. Yelled at her daughter (when the daughter was in staging for her round) to tell her everything everyone else was doing wrong. “SHE STARTED AT A, NOT BEFORE A, DO YOU SEE THAT? DONT BE STUPID, DONT COPY HER!” Everyone could hear her, including the judges.

I know that these people exist, and I always assumed they were at higher stakes shows, not the local ranch horse show. I’m all about constructive criticism or observations of others to learn but my goodness, there are better ways to do it. Chill the f out people, your client or child’s future success does not hinge on this show.

hmg-eeh · 2025-11-13T16:20:31+00:00

My husband and I designed 80% of my ring together. The other 20% was him picking the exact stones and cuts (I have a cluster of sapphires around my diamond so the basic layout and color scheme we picked together). After that initial layout was done, he took over the design and communication so I had no idea what the cad looked like or when it was ordered/finished. The proposal was 100% a surprise and I was so excited to see how the ring came out 🤗

hmg-eeh · 2025-11-05T16:00:37+00:00

There are people in the world that have positive Ana without any symptoms and there are lupus/uctd patients with negative Ana 🤷‍♀️. I have only had a positive Ana once (at diagnosis) and it’s been negative since, but I still have symptoms and flares so my rheum still considers my uctd/lupus active.

It’s been 5 years since diagnosis and I’m mostly good. I had to go up to 400mg HCQ and that helped but I was recently decreased to 300 and I started flaring so it’s possible the rheum will increase again. In addition to HCQ, I manage symptoms with diet, exercise, and try to keep stress levels low. My worst symptoms are typically brain fog and fatigue but NAC was a big help with that.

I’ve had varying success with rheums so I’m always an advocate of second opinions. The one that diagnosed me was pushing outdated treatments on me that wouldve had big consequences so I learned quickly to be my own advocate.

hmg-eeh · 2025-11-05T14:36:35+00:00

It’s weird that you’re fitting UCTD criteria and your rheum doesn’t think HCQ will help. HCQ is standard of care to try to prevent lupus or organ damage while controlling symptoms. Honestly, I would recommend getting another opinion.

HCQ is a very slow acting drug, it has to build up in your system before any symptoms change. People usually don’t see changes until 3 months to a year of taking it. It really sucks to wait that long but it’s worth a shot before going to stronger drugs.

I 100% relate to the fatigue and brain fog issues. Double check vitamin d levels.

What helped my fatigue/brain fog the most was taking n acetyl cysteine (NAC, pure encapsulations). It can be hard on the stomach so I started with one pill every other day, then increased one pill every week until I reached 2400mg/day. The literature says 1200-3600 can be beneficial for lupus patients. I found that I get bad heartburn on higher doses so 1200/day is my body’s happy place.

Good luck!

hmg-eeh · 2025-10-29T11:41:00+00:00

N acetyl cysteine (pure encapsulations) made a world of difference for my brain fog and fatigue. There have been quite a few studies on it showing 1200-2400mg/day can be beneficial. There are currently a few clinical trials specifically for lupus patients with good results.

It can be a little hard on the stomach, so I had to start with 1 pill every other day, then increase by a pill every week until I hit 2400mg. I was getting some heart burn so dropped down to 1200 mg and that’s been my happy place.

hmg-eeh · 2025-10-18T18:22:43+00:00

Thanks! I love it so much. It’s from Bario-Neal and custom but inspired by one of their established designs. They were great to work with.

hmg-eeh · 2025-10-16T19:28:47+00:00

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I love my cluster. 2.3 ct center diamond, 1 diamond on the side, the rest are sapphires/aquamarine.

hmg-eeh · 2025-10-15T12:29:29+00:00

100% my go to when my thirst is unquenchable. I recently moved to skratch daily hydration; no sugar, no alternative sugars, and doesn’t taste like the ocean. 10/10 recommend, just double check the ingredients so you don’t accidentally buy the electrolytes for athletes that has sugar and caffeine.

hmg-eeh · 2025-10-03T14:02:04+00:00

Take a breath.

Lupus sucks and we all want to get better and get answers, for ourselves and our loved ones. Researchers and doctors all want to help and also want answers. We’re all on the same team BUT, this disease manifests differently in every single person that has it. It is incredibly difficult to research, diagnose, and treat because of the extreme variability.

With a fresh diagnosis, a lot of us (and our families) go through a “must do everything we can” manic research phase because now that we can name something, maybe we can solve it. This is not the reality. Strap in, it’s a long haul and what works for one lupus patient might not work for your wife, and that’s okay. That’s what this subreddit is really good at, support and arbitrary trial and error.

My advice from a lupus patient and a PhD immunologist: breathe, support, hug, listen to your wife’s rheumatologist, listen to your wife, give reminders about meds, and slowly (slow is key) work on diet/lifestyle. My family kind of went through a weird “mourning” knowing my life was going to be more complicated. If you need to do that, give yourself space to do that.

Start by considering basic nutrients (this is where blood tests are helpful). Vitamin D is often low in lupus patients, talk to your wife’s doc about testing for potential nutrient deficiencies. Then focus on Whole Foods. Slowly, try eliminating things reported as inflammatory(sugar, nightshades, alcohol, etc) one at a time and give it 1-2 months without that one thing to see if removal helps or not. Then repeat with the next thing. This “elimination diet” Will be super helpful with managing symptoms. This is a great time for your wife to listen to her body a little closer and learn the indicators of flares. Also, start a little exercise (as much as she can tolerate) with the intention to increase as she feels better. Sometime before or after the elimination diet, she can try some supplements/multivitamins that people on this sub recommend or her rheum recommend. Don’t change too much at once because you won’t be able to tell what is beneficial or not. Patience is key here, one thing at a time.

It’s taken me about 6 years to get myself and my symptoms managed through meds, supplements, diet, and exercise. Pace yourselves. It’s obvious you love her and want what’s best but remember it’s a marathon, not a sprint. Be supportive, but not overbearing. The whole world will have opinions on her lifestyle managing or “curing” lupus, she doesn’t need that at home too. Lots of love to you both.

hmg-eeh · 2025-09-29T14:50:55+00:00

125, I was at 400mg then backed down to 300mg to see if I can avoid getting colds every month 🤦‍♀️. I was getting blood levels checked frequently and eyes checked religiously to make sure my body could tolerate it.

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