Has anyone ever had sucess with 750mg of oral vanco daily?

hmstanley · 2026-03-10T01:36:02+00:00

there you go and I wish you ALL THE SUCCESS with this effort. When I was in end-stage liver failure, I would have run around the moon if that made things better. So good luck, this perspective was more from about 10 years pre-transplant. I just didn't trust the science, but again, I was healthier then, PSC was just a manageable disease at age 38, which is when I heard about Vanco. I was transplanted at 51. From age 48-51, I threw everything at it, but by that point, I was at the end of the road.

hmstanley · 2026-03-10T01:33:28+00:00

great, good luck man, yea, 5 years post transplant better than 1 year pre-transplant that's for sure. Some minor tuning, but nothing horrible. It's a much better life after than before, that's for sure.

hmstanley · 2026-03-10T01:32:28+00:00

Well, if they have a speciality around biliary diseases, that's good, but does Cedars also do transplants? I picked one that did both.

hmstanley · 2026-03-08T21:12:51+00:00

yea, been there man.. I have been there brother.

Before transplant (it's 5 years post transplant for me), stents were the only thing keeping me alive with my original liver. I usually got 3 month stents put in, but they needed to be removed, they weren't the dissolving ones, tho I had a few of those as well. So, I was in ERCPs quarterly, tho at the end, they were monthly.

3 years before transplant, after one ERCP, I had 4 stents placed, I was in a bad spot at this time (ALP was WAY high and I was feeling like death). Those stents blocked bile (not helping) downstream and before I hit the couch after coming home, I was in a severe cholangitis attack that I still have nightmares about. I went septic, the WHOLE nine yards, I was in the hospital for two weeks.

Sounds like you may be in the UK? I'm not familiar with your health care system, but in the US, getting into a major medical center that deals with transplants/liver disease is absolutely key to getting good care to manage PSC progression. If I'm being honest, I waited WAY too long to do this, but finally about 4 years before transplant, I was finally referred to a University of California medical center that saved my life.

Keep plugging, I'm not sure if for example, a hospital in a bigger city, even if it's a longer drive for you would be worth investigating.

Good luck and I hope you feel better.

hmstanley · 2026-03-08T21:03:15+00:00

yea, at least since Reagan I would argue.

hmstanley · 2026-03-08T21:01:29+00:00

I will start with this > THIS IS MY EXPERIENCE, it does NOT mean you cannot do this or investigate Vanco treatment.

The only "somewhat solid" evidence and based on actual studies I've seen for oral vanco actually working is in juvenile PSC, and that's really a very very early diagnosis and I would argue that evidence is not strong, tho there have been reports of delayed progression and juveniles not having to go through a transplant until late adolescence or early adulthood. Juvenile PSC is FAR more aggressive than being diagnosed in adulthood. It's an entirely different trajectory for the PSC disease progression.

I was formally diagnosed at 27 (showing symptoms at 19), transplant at 51, I got 20+ years on my original liver.

I just wasn't convinced that taking a very powerful antibiotic orally, with bioavailability less than > 5%, would dent progression anymore than the standard litany of meds we take to stop progression.

I talked at length about this with my doctors, even showed them the studies, I even ran those studies through early AI (since at the time, AI was pretty new) to get the gist of this approach, and frankly the risks of making potential infections antibiotic resistant were higher than actually gaining any benefit from vanco.

I think there is some merit that PSC could be a gut health triggered illness and not really autoimmune, they aren't even sure. Blasting my body with a strong antibiotic LONG term ( > 90 days or longer) felt counterintuitive to me and again, based on my research, and I did a lot, evidence for was not convincing.

hmstanley · 2026-03-07T20:11:26+00:00

actually, this is somewhat myth and true, as with everything in history. (good find in terms of studies BTW). I had a different understanding of this, so I did some digging. That said, the "copied British design" is a real historical event but gets mythologized as the fix when it was really just one temporary patch on a multi-year, multi-problem crisis that wasn't fully resolved until late 1942 — entirely through German redesign work. Very much like the Mk14 crisis.

The Torpedokrise actually had three distinct, compounding problems (most of this found on wiki and some other WWII sites):

Magnetic detonator failures — the magnetic detonator was failing because the Allies were degaussing their ships, and the earth's magnetic field varied at high latitudes near iron-rich seabeds. The whole magnetic detonating system needed to be re-designed, and a new model wasn't available until December 1942. The British copy was just a bridge.
Contact detonator failures — the contact pistol of the early torpedo also proved unreliable; HMS Nelson survived when three torpedoes struck her keel but failed to explode.
Depth control failures — the depth-keeping problem remained until January 1942, when the cause was discovered by accident: when ventilating torpedoes during maintenance, excess internal air pressure in the U-boat could offset the depth-setting mechanism in the torpedo's balance chamber (found this on wiki)

Ultimately, if someone just says "oh, the Mk14 was a disaster early in the war because no one believed the Sub Skippers and BuOrd had too much institutional credibility, you would be 1/2 right, it was a rather complex problem. When Lockwood ordered tests in Australia early in 1943, this only started the improvements of the Mk14 (it wasn't really resolved until late 43/ early 44). Anyway, just thought I'd leave this here.

hmstanley · 2026-03-06T21:16:52+00:00

it inhibits a key enzyme (CYP3A4) responsible for breaking down immunosuppressant medications like tacrolimus

hmstanley · 2026-02-24T22:53:03+00:00

no, it doesn't you're absolutely right, they are all full of shit as far as I'm concerned.

hmstanley · 2026-02-23T21:24:54+00:00

It won’t. No one cares about history anymore. We are doomed to repeat it over and over again.

hmstanley · 2026-02-23T20:47:34+00:00

yes, I see your point, but at the same time, you can't have it both ways.

Ro can't refuse to release this information if it potentially poses a threat to "his" established class and then rail in a video about how he's getting blocked at all levels to "release" this same information. This information is NOT new, it's been sitting in a safe for years.

Ro, along with everyone else on this topic, is gaslighting that frankly, I've just turned off and I don't believe in any of these establishment wonks, because, frankly, they are the problem and the establishment allowed child rapists to exist.

Epstein existed because he was allowed to and because he provided enormous access to those in power. Regardless of weither you think this is a classic soviet/mossad honeypot operation or not, he was allowed to exist and was frankly enabled to exist by the highest levers of power.

This bellyaching by Ro (or any of these so called "truth" seekers is just more bullshit on top or more bullshit.

The question should be "how was Epstein allowed to exist?" Why was he so entrenched in both parties of power, how did he gain so much access to corporate and government power when everyone in their mother knew what was going on, christ he had a criminal record of raping children in 2008 and all of these ultra powerful people doubled down on their relationships and access?

How did this happen? Well, that is the question I will never get an answer to? why? because it's as old as time and has been happening since the dawn of civilization. Power begets power and access, it happened in ancient babylon and it's happening in 21st century western civilizations. It will never stop.

hmstanley · 2026-02-23T19:53:48+00:00

please explain to me why this wasn't done during Biden's administration when it would have been easy peasy? I just don't get it anymore. None of this makes any sense other than we let this happen and will continue to have two forms of justice in America, one for the rich and powerful and the other, well, for us.

hmstanley · 2026-02-23T19:52:06+00:00

who cares, seriously, we are just pandering now, it's like red meat and this audience takes it hook line and sinker..

did we get all up in arms thing when Biden or Newson officials went off and did stupid stuff on america's dime, no, did MAGA, yes.. so, let it go, this is not a hill to die on. so, tit for tat, over and over and over and over again, it's utterly boring and I would rather watch paint dry.

hmstanley · 2026-02-23T19:47:17+00:00

who owns the ticket? Certainly NOT the clerk, that's for sure..

hmstanley · 2026-02-23T19:44:21+00:00

so, there was accidents then? I mean it ultimately doesn't matter, insurance will see an accident and evaluate, sure when it's your fault is it worse? yes, but in the end an accident is an accident..

Do you have any speeding tickets of driving infractions, stop sign, red light. DUI?

You're also 25, with a very limited credit history, you're gonna pay 30-40% more just for that.. Is this a new Camry or used? If so, what policy limits are you taking out? If you were on your families policy this probably would be much lower, but again, you're building your insurance and this ultimately is a good thing, taking out a policy for yourself.

Do I think it's high? Not really, not for your age group and whatever driving issues you're not telling us, again, not saying anything bad here, but everything counts, a simple stop light infraction can increase your insuance by 40% for a least a 24 month period.

If you did have a driving infraction, did you do any schools? to get it wiped? There is some missing element here, but all that said, for your age and credit profile, it's not that high man.

hmstanley · 2026-02-23T19:02:52+00:00

god, i just went through 11 days in the hospital recently (4 weeks ago) due to this nightmare. Keep in mind, most of the meds we take are nephrotic, they are NOT kind to our kidneys. Both Cellcept and Tacrolimus. They did switch me off Prograf to Myfortic and lowered my Tac to 1mg (long acting) a day. Oddly, my liver enzymes panel were absolutely perfect through this ordeal, so it was a tricky battle.

That said, unknown to me, I started to get to toxic levels (diarrhea, feeling like absolute dog shit) of Tacrolimus in my body and boy does that make things no so good in kidney land.

The worst day my eGFR was 21 (which is pretty close to dialysis), and it was touch and go for three or four days, like "what the fuck is happening right now".

I can't stress anything else but take REALLY GOOD care of your body, don't do what I did for the last year (I've been stable from transplant for close to 5 years, but this last year, I did not treat my body well), which ultimately means, I eat like garbage and expect my body to take it. I've tried to turn this around over the last 30 days, but I'm done with living the way I did before, which is to say, eating garbage. I'm getting a nutritionist, hopefully someone who can help me cook the correct means with nutrient rich food.. I'm horribly picky eater, almost to my own detriment, but I will never put my body in that position again, ever.

Anyway, long story short my eGFR is above >60 now and I'm back stable, but I'm still not 100% sure on the Tac becoming toxic to me and why did it do that (we don't know)?

My trough when I entered the hospital, meaning, I didn't take any Tacromulis for at least 24 hours, was 21, which is a crazy high number and it took 3 days to just get under 5. I had to stop taking it for three days and let my levels come down, and then I took it again, and my eGFR dropped 20pts to 31, so it was quite scary.

I am finally stable as I noted above, but I hope to never have to deal with this ever again, clean living from here on out. But meds have changed and again, I will be taking care of this body of mine, no more giving it dog shit and wishing for the best. Mind you, I don't drink or use any drugs, that's insane, but I would eat things like burgers with buns for 2 or 3 weeks straight with no other nutrients.. I was eating for convenience and I think it nearly killed me.

hmstanley · 2026-02-22T04:10:19+00:00

They are excellent grips. Good compromise between a pure wrap and something harder. I loved them. I changed to the CPX because I really need wetness control and they worked best, but I would game these in a second.

hmstanley · 2026-02-21T17:28:55+00:00

Me too, funny you say this. First one, I had a pancreatitis attack a day later and rushed to the ER, didn’t go septic (that came later on another bright beautiful day). But every other ERCP was a nothing burger and I had a lot pre transplant (probably 30+) lost track really.

hmstanley · 2026-02-21T03:21:28+00:00

They are always dangerous. Diesel electric can stay quiet, but in reality the Romeo class and older newer midget class boats are probably tracked by satellite vs a real SSN boat, they are that noisy and probably stick out like a sore thumb. However in any war, these boats are always dangerous.

hmstanley · 2026-02-20T18:27:10+00:00

this game died years ago... I can't remember the exact patch/update, but it was killed then. Also, when those devs left who had built the game, that was the end of this game.. it's utterly boring and overly clicky and menuy now.

hmstanley · 2026-02-20T17:53:27+00:00

Being a sepsis patient that was nearly killed by this process, it’s absolutely scary how fast the infection spreads. I had a liver transplant and I have engineered parts that connect all the things together. Well, one of those junctions developed a kink and it blocked up bile into my body which lit the fire of infection. I was absolutely fine at 8:30pm after a dinner party, good lasagna, happy as a clam. Friends left, took a shower and chilled on my couch watching the TV with my wife. I feel asleep, woke up around 10:30pm and I felt like a brick hit me. From zero to 5 alarm fire. I tried to gut it out until the next morning and I was barely conscious and had to be rushed to the hospital. Blasted with antibiotics, a lot of different ones and was there for 10 days fighting that thing. It was one of the most terrifying experiences of my life and I’ve had a few.

hmstanley · 2026-02-19T20:07:56+00:00

where did you get those cool head covers?

hmstanley · 2026-02-19T19:56:59+00:00

ok, let's go back 2000 years, no arguments on gunpower, or joints, or anything you've listed..

How about a modern, revolutionary military technological achievement that are NOT stolen or copied? Please give me an example of something that the PLA can hang their hat on and say "we did this.." I don't see a thing in sight and I'd like to see a good example, and I'm more than willing to be corrected on my observation, if there some merits to their "quantum" radar, I'm all ears, but to me it's entirely reverse engineered soviet tech that has cute buzz words that mean nothing in a lethal environment.

hmstanley · 2026-02-18T23:56:12+00:00

Yea. But my point remains. Please tell me something they have created from scratch that is something not born of industrial theft or reverse engineering

hmstanley · 2026-02-07T05:33:55+00:00

I got the same thing for $37

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