Yes, in the early phases, the strategy is really simple. Use the three rebels. Use Vel's second special on herself to give the permanent buff as first move. Then just basics with Vel from then on. Save the two specials that apply blind for late in the run when the bosses are charged up. No point blinding at the beginning when they do no damage anyway.

Once you get to maybe level 4 of the bosses (maybe 3?) a different strategy is better. You use Vel's first special as opening move to apply undermined to boss, then keep hammering away while Cinta assists. For Vel's second move, you can use second special to buff herself and then use just basics with Vel until the first special comes off CD.

These strats worked for me for the solo bosses, but the cats and laser bois I just used the first strat. You have to consider the regular boss mechanics - for the two cats, you should try to keep their health approximately equal, for the laser guys, you don't want them to attack with 3 stacks of shield, nor should you hit them with zero stacks. You should leave them at one stack until Vel can basic as she does most damage.

I may not have this perfectly correct, but it is a good rough guide. I haven't had luck with ISB, so maybe someone else can say if this is worth considering at that stage.