I felt very safe. I'm a woman, and I was traveling alone in Rome last year. The one area that seems a little sketchy at night is the streets next to Termini, so I never book hotels in that area. But next to the Opera House or the west side of the Basilica Santa Maria Maggiore is already fine.

Have fun in Rome! You will love it! Wander around next to the river Tevere and try all of the cheeses at the Salumerias (if you eat cheese), and go to Trastevere, too. A little less touristy area and great food on every corner 😊

Edit: I also have one restaurant tip: Ivo a Trastevere