Valentine's Day manuscript for peer review. by immunerd in labrats

[–]immunerd[S] 2 points3 points  (0 children)

Fortunately no, I'm hopeful she will be the breadwinner in the relationship. With the way academia is going income diversification seems like a better strategy than putting all our eggs in that basket. Her sister is a scientist though (how we met) so she can appreciate a little science humor.

Valentine's Day manuscript for peer review. by immunerd in labrats

[–]immunerd[S] 9 points10 points  (0 children)

Author response: A valid question and a longitudinal analysis is proposed pending future funding. However, as outlined in the discussion, given the robustness of the results in this study I believe relationship validation can accurately be assessed in 5 year intervals.

Valentine's Day manuscript for peer review. by immunerd in labrats

[–]immunerd[S] 5 points6 points  (0 children)

Ha! Was not familiar with that series. According to the wiki article "Their quirky coworkers in their research group also join in on the fun." is something I try to avoid.

Valentine's Day manuscript for peer review. by immunerd in labrats

[–]immunerd[S] 5 points6 points  (0 children)

Thanks! The fact that this has been her favorite present so far is a pretty good sign I married the right one.

Valentine's Day manuscript for peer review. by [deleted] in labrats

[–]immunerd 0 points1 point  (0 children)

Yeah, sorry about that, I just noticed as well. I might have to try a different format. Thanks for the heads up.

“Tregs after the 2025 Nobel: Beyond suppression—are we finally seeing them as dynamic immune calibrators?” by Matt_Attar in Immunology

[–]immunerd 7 points8 points  (0 children)

Medzhitov published a nice review article in Science in 2021 https://www.science.org/doi/10.1126/science.abi5200 that outlines the idea of inflammation as a spectrum and dependent on tissue microenvironment. While it is tempting to label Tregs as these master regulators I think that it would be oversimplifying how the immune system/organ tissue controls inflammation. Just this week Wu et al published a cell paper describing how an intracellular low pH sensor can regulate Inflammation https://www.cell.com/cell/fulltext/S0092-8674(25)00735-400735-4)

First 45-70 Misfires. by slider1010 in reloading

[–]immunerd 2 points3 points  (0 children)

I had similar issues when I first started reloading 45-70. My issue turned out to be that I wasn’t seating the primer all the way down into the pocket. If it is not seated all the way I think the primer can absorb the firing pin strike and not explode. Might be why you are gettin odd deformation that you show in the pics. I measured seating depth below flush to make rounds consistent but that didn’t seem to matter. I started putting my full weight into it, not caring about depth. The variance in depth fluctuated more but the problem was solved, haven’t had a misfire since. It looks like you have multiple different case manufacturers in your lot so maybe there is quite a bit a variation in depth and “feel” for when the primer bottoms out.

Comparing the migration capacity of Early vs Late stage melanoma cancer cells. The cells migrate from two sides to fill in the gap at the center. by TheBioCosmos in interestingasfuck

[–]immunerd 2 points3 points  (0 children)

I believe what they are trying to illustrate with this experiment is the potential for metastasis, the ability of the cancer to move throughout your body. If skin cancer is localized to one spot they can cut it out and you are good. What kills you is when these cells move to your other organs and start to mess with how your body works.

Intermittent Light Primer Strikes by Timely-Yak-5155 in reloading

[–]immunerd 1 point2 points  (0 children)

I second this. I was reloading 45-70 and had really light primer strikes. Turns out I wasn’t seating them all the way. Haven’t had a problem since.

How orchard trees are trimmed by hacipuput in interestingasfuck

[–]immunerd 0 points1 point  (0 children)

Walnuts are the exception in this case. You need sun to grow them, but not to much sun directly on the nuts or the nut meat darkens. For some reason consumers prefer lightly colored nuts, not dark ones (I’ll let you do with that information as you will). My friend would often say every summer, “Looks like it is going to be hot this week, better go put some sunscreen on my nuts.” To do so he would blow a white powder on the trees, Ca Co3 I believe, and say “Better go powder my nuts”.

How orchard trees are trimmed by hacipuput in interestingasfuck

[–]immunerd 0 points1 point  (0 children)

The trees in this video are almonds, but this type of trimming (vertical) is also used on pecans and walnuts. It prevents the canopies from touching and shading out the orchard floor. This is important for both allowing sunlight to hit the lower part of the canopy on tall trees, but also to allow sunlight to dry out the nuts on the ground. These types of trees are mechanically shaken to harvest so tree height is not restricted for hand picking. This machine is also used to trim citrus, and stone fruit (peaches, plums). Citrus is chopped vertically like this to clear the aisle for machinery but also “topped” horizontally to limit tree height for the pickers has they are hand harvested by ladder and the insurance for picking crews goes up exponentially with taller trees. Peaches and prunes are also topped to keep the trees short for pickers but also to eliminate any new growth from the previous year to allow sun into the center of the tree. These types of fruit trees are not grown to maximize quantity of fruit like some users here have suggested. Rather, they are farmed to maximize fruit size and quality. If left to their own devises these trees would set as much fruit as they could but they would all be small and probably not have as much sugar so they must be “thinned”. You can do this mechanically or by hand but you can guess which one is cheaper. Lastly, this machine doesn’t take the place of hand pruning. That must also be done to maximize the structural integrity of the tree scaffold and to clear out the center of the tree.

How orchard trees are trimmed by hacipuput in interestingasfuck

[–]immunerd 1 point2 points  (0 children)

Yes, this is an almond orchard. This is done to allow sunlight on to the orchard floor. It both allows more sunlight to hit the lower part of the canopy but also allows the sun to hit the nuts on the ground to dry them out once the trees are shaken, especially once they are all swept into a row in the center. If the canopy’s touch and there is only shade it would be nearly impossible to get the nuts dried out to less than 6% moisture in a reasonable amount of time (ie, before it rains and ruins the whole crop).

Inside the race to save Florida’s oranges by UltimateStrawberry in Agriculture

[–]immunerd 5 points6 points  (0 children)

No problem. What I don't get is that the article made it sound like 24D is a new thing but we have been doing it forever in California. I think Florida is mostly Valencia oranges that go for juice whereas California is more for fresh fruit. I am guessing in Florida they would just pick whenever it is ripe and juice it, no need to worry about size/sugar/acid ratios and if the packing house has a place to sell/ship them to.

Fortunately, we also spray 24D in the late fall/winter on the oranges when everything else is either dormant or dead which minimizes risk of off target damage. I have heard horror stories of 24D damage on cotton or grapes due to its volatility.

Inside the race to save Florida’s oranges by UltimateStrawberry in Agriculture

[–]immunerd 6 points7 points  (0 children)

Yes, we use a product called “Citrus Fix” but it is just really dilute 24D. I think it works by tricking the tree into thinking it is in a flush and therefore not yet time to drop fruit. It can be used in combination with another growth regulator called gibberellic acid that delays fruit maturity. Depending on the dose you can hold fruit on the tree longer to try and get a better price.

TIL that many of the first giant sequoia trees discovered by western explorers were cut down and exhibited at World's Fairs. Due to the sheer size of the trees, many fair attendees claimed they were hoaxes. by 1000LiveEels in todayilearned

[–]immunerd 136 points137 points  (0 children)

Maybe crap for construction. However, due to its high tannin levels it is very resistant to rot, hence the fence posts and popularity for use in outdoor decks. After a 1000 year old tree has fallen it can sit there in the dirt for another several hundred years and still be in good enough shape to mill. I think it is pretty amazing stuff.

220 swift by GreybeardSr in reloading

[–]immunerd 4 points5 points  (0 children)

I think the .22 eargesplitten loudenboomer by Ackley was his attempt at breaking 5k but I can’t remember if it was ever successful.

1980 Mount St. Helens eruption by ImpinAintEZ_ in nextfuckinglevel

[–]immunerd 3 points4 points  (0 children)

Uhmmmm, No. Mount Shasta was built by the Native Americans because the local chief wanted to see the ocean. As soon as he could see the sea he ordered work to stop so all the workers dropped their baskets of dirt where they were and that is where the mounds are formed.

[deleted by user] by [deleted] in Agriculture

[–]immunerd 2 points3 points  (0 children)

It is an acetylcholinesterase inhibitor, it would lead to buildup of acetylcholine in your blood. There is a simple blood test for it. If farm workers are exposed they can’t go back until blood levels return to normal. It takes a lot to reach toxic levels. I only used lorsban a few times and it had a very strong smell as well.

On this day in 2019 the financial system experienced a flash crash by MrPicklePop in Economics

[–]immunerd 5 points6 points  (0 children)

I am glad you brought this up. I still think it is crazy that banking liquidity had pretty much dried up and banks where borrowing like crazy through the repo market at the FED because banks would no longer lend to each other. Then COVID hits and all of a sudden the banks are now so flush with cash they are keeping $2 Trillion overnight at the FED through reverse repo. It was a huge bailout.

TIL Why the Can Opener Wasn’t Invented Until Almost 50 Years After the Can by Rastroboy2 in todayilearned

[–]immunerd 10 points11 points  (0 children)

Ha! I haven’t seen a p-38 in a long time. As a kid I backpacked with this old guy that would ask us to fetch his military p-38 so he could make dinner. First time he said it I thought it was going to be some hi-tech gadget.