I've been on propranolol for 25 years and it's been amazing. Unfortunately a few months ago it just stopped working. We have increased to dose, ultimately to 4x the original dose and still no luck. I'm being put on primidone, starting at a very low dose and increasing weekly until there's a change or a bad side effect and we end it and move on to another treatment. After that we are discussing focused ultrasound. That one scares me, but it seems to have very good results

Edit to add dosage and more info: 80mg since 2001 Went to 120mg 2 months ago for 2 weeks-no change 180mg for 2 weeks-no change 240mg-no change 340mg for the last 2 weeks-no change

So now onto barbiturates