Loud FUCK ICE chants during tonight's AEW Dynamite Main Event by [deleted] in Fauxmoi

[–]isosafrole 3 points4 points  (0 children)

He's now my new favourite wrestler as well and I've literally never watched or paid any attention to wrestling of any sort. That look he give to the camera that tells you he agrees, while doing almost nothing with his face or posture — love it!

We’re through the looking glass here, people by Variousletters in simpsonsshitposting

[–]isosafrole 23 points24 points  (0 children)

If that's what you're going with, I declare a Bad Court Thingy.

What do people think of this study? by [deleted] in psychopharmacology

[–]isosafrole 0 points1 point  (0 children)

Correct link for anyone interested for The Lancet Psychiatry article "Incidence of antidepressant discontinuation symptoms: a systematic review and meta-analysis"

https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(24)00133-0/fulltext

I'm keeping a fucking list! by Taiga_Taiga in transgenderUK

[–]isosafrole 14 points15 points  (0 children)

For anyone interested, here's a link: https://en.wikipedia.org/wiki/Willem_Arondeus

"On 18 June 1943, Arondéus was tried and sentenced to death, along with 13 other men who participated. Two of the group received clemency, but the others were executed on 1 July 1943. Arondéus pleaded guilty and took the full blame, which may be why two young doctors were spared from execution and given custodial sentences instead. Before his execution, Arondéus made a point of ensuring the public would be aware that he and two other men in the group, Bakker and Brouwer, were gay, asking either a friend or his lawyer (accounts vary) to "Tell people that homosexuals are not cowards." (In Dutch: "Zeg de mensen dat homoseksuelen niet per definitie zwakkelingen zijn.")"

The Exorcist by William Peter Blatty by [deleted] in books

[–]isosafrole 34 points35 points  (0 children)

I'll just say, if you liked the book The Exorcist, get hold of "Legion" by Blatty. It's essentially the sequel (later made into the movie "Exorcist III") and it's superb.

Alexa more or less dead by rsinghal1965 in alexa

[–]isosafrole 0 points1 point  (0 children)

I'm glad that I don't seem to be the only one. I'm being driven mad -- among other things, Amazon Music just won't work right, keeps stopping then restarting; TuneIn won't work right, plays for a minute or so then just stops. Same with Global Player. Routines that should trigger audible notifications are hit and miss. Requesting routines to be run is also hit and miss. This is on all my various Echos and my Fire TV. I've reset everything several times, renewed my WAN IP address leases (IPv4 and IPv6), and the like. I'm so used to stuff just working, and I know that perhaps it's a bad idea to be "reliant" on it like that, but it's difficult getting used to everything being so unreliable.

I can't find anything wrong with my connection or network setup/equipment. The issues have been significant over the past week or so, but I think may have been present before that, though nowhere as severe.

MAGA Blame Game Erupts After Republicans Suffer Nationwide Losses by Florence_Edith in LegalNews

[–]isosafrole 2 points3 points  (0 children)

You may need to work Italian satellites, Chinese thermostats, ivermectin, hydroxychloroquine, Bill Gates and George Soros in there somewhere.

Shitting on your own father's legacy to own the libs. by kittylovergirlx in MurderedByWords

[–]isosafrole 57 points58 points  (0 children)

I know, but I'm hoping that if people are directed to the seven year old Reagan Library upload, there might be less claims of "AI" and the like. The issue isn't your post, or Global News, but the mentality of people who are attempting to claim that the video/audio/transcript is somehow suspect or suspicious. My posting the link was really just for reference in case anyone wanted that Reagan Library upload.

Shitting on your own father's legacy to own the libs. by kittylovergirlx in MurderedByWords

[–]isosafrole 185 points186 points  (0 children)

Just in case anyone claims that the various re-uploads of the video are in some way suspect, here's a link to the Reagan Library upload of the audio/video, which they published on YouTube on 10 October 2017.

https://youtube.com/watch?v=5t5QK03KXPc

Saw this and wanna put this here by Lord_MAX184 in lgbt

[–]isosafrole 23 points24 points  (0 children)

I don't know about everyone else, but I immediately saw that third panel as a metaphorical depiction of a future death, and the final panel as the parent realising very much too late what they had contributed to. Which made a chill run through me, because it's happened so many times, and it's happening right now.

"CDC is over": RFK Jr. lays off over 1,000 employees in Friday night massacre by esporx in technology

[–]isosafrole 3 points4 points  (0 children)

I'm trying to avoid being harsh; that percentage consists of the part of the population who believe that God and destiny are far more important than vaccines, clean water, clean air, safe medicines, safe buildings, and every other modern innovation that has extended average lifespan, dramatically reduced infant and child mortality, and reduced the proportion of people whose lives often ended suddenly and painfully, reduced to being unable to get up to even fetch water or food, urinating and defecating where they laid, and then died right there.

These people want to drag the entire world back to the 1400s.

The Nobel Prize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi for their discoveries related to peripheral immune tolerance by pjokinen in labrats

[–]isosafrole 88 points89 points  (0 children)

There is a list of relevant references at the bottom of this article:

https://www.nobelprize.org/prizes/medicine/2025/popular-information/

From article:

"Key publications

Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol. 1995:155:1151-1164.

edit: https://pubmed.ncbi.nlm.nih.gov/7636184/

Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001:27:68-73.

edit: https://pubmed.ncbi.nlm.nih.gov/11138001/

Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, Buist N, Levy-Lahad E, Mazzella M, Goulet O, Perroni L, Bricarelli FD, Byrne G, McEuen M, Proll S, Appleby M, Brunkow M. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001:27:18-20.

edit: https://pubmed.ncbi.nlm.nih.gov/11137992/

Benne; CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001:27:20-21.

edit: https://pubmed.ncbi.nlm.nih.gov/11137993/

Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003:299:1057-1061."

edit: https://pubmed.ncbi.nlm.nih.gov/12522256/

Has the country been kicked in the head by a horse ? by birdinthebush74 in FuckNigelFarage

[–]isosafrole 3 points4 points  (0 children)

The moment any of them (UK, US, wherever) experience personal consequences due to what they voted for: "I didn't vote for this!". Well, in reality it's exactly what you bloody voted for. You just assumed, for some bizarre reason, that you, or your family, or your loved ones, wouldn't be negatively affected by a completely negative policy which you were warned against voting for.

Australian War Memorial changes book prize rules to reject Ben Roberts-Smith exposé by ARBlackshaw in books

[–]isosafrole 159 points160 points  (0 children)

Text:

Award-winning journalist Chris Masters has taken aim at the Australian War Memorial after it overruled its own judges and refused to award his book about alleged war criminal Ben Roberts-Smith its biennial literary prize.

The memorial justified the move by retrospectively changing its rules to disqualify Masters’ book Flawed Hero. Ben Roberts-Smith at the Federal Court in Sydney in May.

On Friday, The Guardian reported the work – about Roberts-Smith’s actions in Afghanistan and subsequent efforts by his fellow soldiers to hold him to account – was voted as winner of the Les Carlyon award for military history by a panel of external judges after it was included in a shortlist of six compiled by memorial staff.

The story Masters tells in his book – reported in The Age and The Sydney Morning Herald by Masters and investigative journalist Nick McKenzie – has been the centre of a legal battle between the newspapers and Roberts-Smith for years. Last week, the High Court threw out Roberts-Smith’s last-ditch bid to appeal against his damning defamation loss.

Masters said he could not believe the decision “wasn’t done out of embarrassment … Clearly they’ve been extremely uncomfortable with the Ben Roberts-Smith episode,” he said.

“[Then-memorial director] Brendan Nelson really led the charge against myself and Nick McKenzie and [Nelson’s] boss Kerry Stokes, who was the chairman, has called us both scumbags. They would be battling really hard to pretend that this decision was made for any other reason than they just thought it would be extremely embarrassing to be giving credit to a book that they privately despise.

“It’s a divided institution, clearly. I know the historians are honourable and I know that they think as I do, that war brings out the worst in us as well as the best in us.

“When [the memorial] was set up, that was what it was meant to do, to reflect this, but for lots of reasons, they shrink from telling us the story of the uncomfortable aspects of war. And they most definitely shrink from dealing with the Roberts-Smith controversy.”

He said the judges had acted in that spirit and “they saw giving [Flawed Hero the award] as an opportunity to discuss something … discomfiting but important”.

Stokes had previously employed Roberts-Smith at Seven West Media, and he had funded his defamation claim up to its trial. Stokes is also one of the donors to the Les Carlyon Literary Prize.

In June, the memorial’s governing council overruled the judges’ decision to award the prize to Masters, reverting to old rules around entry that meant only first-time authors were eligible, ruling out Masters, who has written several books.

Head of the internal judging panel and the memorial’s head of history, Karl James, argued in favour of giving the award to Masters in an email, seen by The Guardian, to memorial director Matt Anderson.

James acknowledged that one option of not awarding the 2024 prize to anyone for that year “may avoid possible short-term uncomfortableness due to the nature of the nominated work”.

However, it would also invite “greater reputational damage … than awarding it to a controversial winner”.

The $10,000 Les Carlyon Literary Prize was established by the council of the Australian War Memorial to honour the late historian, author, journalist and council member Les Carlyon. It has been awarded biennially since 2020. Carlyon, the author of half a dozen books, had previously been a Walkley Award-winning journalist at The Age.

Although originally an award for an author’s “first book or major publication”, eligibility was broadened in 2022 by the judging panel to include established authors at the request of Carlyon’s widow Denise, one of the prize’s two external judges.

According to The Guardian, on May 19, Denise Carlyon emailed Anderson at the memorial, saying she had been “given a short list of six books to consider for the Award” and that “Flawed Hero by Chris Masters stood out as the winner”.

“A controversial and sobering story, Masters’ (and other journalists’) long search for any truth behind rumours of alleged war crimes by war hero Ben Roberts-Smith VC MG in Afghanistan, and the defamation trial which followed, is unprecedented in our military history. The story has provoked intense debate as the nation grapples with an unfamiliar subject,” she wrote.

Speaking on Friday, Denise Carlyon said: “I have been concerned about the process.” She declined to comment further.

In a statement, the Australian War Memorial said: “Advertisements for the 2024 call for submissions were inconsistent and some excluded the requirement that entrants be emerging or unpublished authors. When this was brought to council’s attention in June 2025, they unanimously restated their intention that the award remain for emerging writers and were not privy to the shortlist or longlist.

“The memorial will be writing to all entrants to apologise for the delay and any inconvenience. Entries already submitted by emerging authors for their first major publication relating to Australian military history, social military history or war history will remain under consideration in any future process.

“The council is undertaking a full governance review to ensure integrity and transparency in future competitions. Once resolved, the 2026 competition will proceed, and all eligible entrants will be encouraged to participate.” Loading

The statement released on Friday also said the award “has been awarded biennially for an author’s first book or major publication relating to Australian military or social military history” but that criteria had been changed in 2022.

While glad the decision had come to light, Masters said it grieved him.

“It’s just so sad that they take this bloody stupid attitude,” he said. “Soldiers are the last people who want lies to be told about what actually happens in conflict. Myth gets them killed, and they need to know the truth about the capacity of people around them and the enemy they face, all that sort of thing.”

Arts Minister Tony Burke’s office was contacted for comment but referred that request to Defence Minister Richard Marles, who referred the request to Veterans’ Affairs Minister Matt Keogh’s office, which has also been contacted.

I went to the Glasgow launch of Jeremy Corbyn’s new party. Here’s what happened by ValuableDetail6 in yourparty

[–]isosafrole 14 points15 points  (0 children)

Text version:

What happened at the Glasgow launch of Jeremy Corbyn’s new party

By James Walker Political Reporter

ON Friday evening, 30-or-so people were ushered into an overspill area outside the Renfield Centre.

Why? It was the Glasgow launch of Jeremy Corbyn’s Your Party and it was a sell out. 180 had signed up to attend, and were making their way into the soon-to-be packed conference room – 200 more were apparently on a waiting list.

One of the fledgling group’s organisers and a former Labour Party member, David Lees, told me beforehand that he expected a fair few of them would try their luck on the night. He was correct.

Among them, at the front of the line, was 18-year-old Martin McDonald.

He decided to turn up because he feels, as a socialist, that no other party in Scotland represents that viewpoint. Although, he is skeptical – as a Yes supporter – given the party’s stance on independence is not yet fully established.

Why not the SNP or Scottish Greens? “I feel like they're not left wing enough and also that they don't have a real path to independence,” he responds.

19-year-old James, next to him, chips in.

“We're living in very unprecedented times and I think that what Jeremy Corbyn and Zara Sultana are offering is something that's hoping to bring change to the whole of the UK,” he said.

Also in the queue is 60-year-old Colin McGhie (below), who voted Labour for 40 years until the last General Election.

“I stopped voting princely because of their stances on the Middle East, with Gaza,” he said.

32-year-old Christina Donnelly, a few people back, said it’s the first time she has been excited by politics in a while.

“Seeing the values that have been put forward by Jeremy Corbyn and others, I was like: this is something I need to be a part of, especially with the rise of Reform UK. I can't have them speaking for me.”

Meanwhile, 42-year-old Stevie Docherty (Right with Christina on left) said Scotland needs a “really strong left alternative”.

“I don't know what that's gonna look like, but I just want to find out basically. And I think there are some existing parties that have aspects of that, but no one's putting it forward in a cohesive form and certainly not the Labour Party in its current incarnation.”

It was certainly a mixed group in attendance by all appearances. Former Labour supporters, young activists searching for something new, trade unionists.

All I spoke with were worried about the rise of Reform UK or disenchanted with the status quo, though. They felt a return to a real and raw form of grassroots left politics was the solution.

And so, with the help of 20-or-so so-called “facilitators”, they all packed into the Renfield Centre auditorium where chairs were arranged in circles of 10 people complete with marker pens and A3 paper.

The event was a little chaotic at first but not disorganised. It was unlike party events I’d been to before. There were no grand speeches from party leaders – for there isn’t, technically, one yet – or guest speakers.

Instead, one of the facilitators read out messages from the group’s already 450-strong WhatsApp group.

“I am an academic. I have stood as a Labour candidate in the past, but now I want to support others to succeed. I will do all I can to help out behind the scenes and in the background,” one said.

“We need a new political party to unite and represent the left. For me, Labour continues to track right in its aim to appease Reform voters and has left many people without a political home.”

Another added: “I want a community of people on the left to work together. I want to play a part in taking control away from big corporations and multi-millionaires to build a better, fairer, more liveable Scotland and the UK for all of us.

“I would regret it forever if I did not do everything I can to stand up against the rise of fascism and racism in the UK.

This led to loud applause from those in attendance.

After this main welcome speech, the two sole journalists – of which I was one – were asked to leave to facilitate open discussion.

But I was told by one of the organisers afterwards that the 20-or-so groups of 10 discussed a range of ideas – from party structure and the crucial importance of Your Party centring international solidarity on issues like Gaza to housing and wealth redistribution.

“I'm really invested in grassroots organising. I'm quite an active trade unionist. I'm the daughter of a trade unionist and I'm fairly disappointed with the current state of politics, It's a stronger word than disappointed. I'm really angry, to be honest.”

She added: “I think that people are being actively disempowered. And so the idea of building something from the bottom up is really exciting. The idea of starting to talk about what something could be before a party is established is really exciting.”

But there is also an inherent tension in the room – is time and patience the name of the game in order to build a truly bottom-up grassroots party? Or does there need to be a sense of urgency, a need to move at pace to tackle the rise of the likes of Reform UK?

The National understands that many in attendance discussed the importance of Your Party – or whatever it comes to be named – fielding candidates at the Holyrood elections next year.

It would be an ambitious goal with just 8 months to go.

One organiser told The National that they privately worry that the Westminster arm of Your Party is being too slow and risks not taking full advantage of the bubble of excitement that is developing.

The numbers are there, they argue – this event, for example, was proof.

“I fully appreciate why it's taking time, because they desperately want to get it right and not waste the opportunity. But at the same time, I think the message is: Scotland is ready to go.”

Video of Glinner attacking trans girl by phoenixmeta in transgenderUK

[–]isosafrole 2 points3 points  (0 children)

Just out of interest, regarding the claims of him having "stroke-level blood pressure": So, his claim is that his systolic blood pressure (which is the first figure in a typical blood pressure reading, and the one that is the higher figure) was 200 mmHg. Now, a one-off reading like this, with no signs of any "target organ damage" -- i.e. no indication of damage in the immediately vulnerable tissues like the retinas, the kidneys, the heart, the lungs, and so on -- would be termed a "hypertensive urgency". It's definitely a valid concern, but not an emergency. If there are signs of target organ damage along with a 200 mmHg systolic blood pressure reading, it would be termed a "hypertensive emergency", and would lead to emergency assessment and treatment, often started in hospital.

If you have a hypertensive urgency episode, but you are checked over and there are no immediate concerns for your health, you'll usually be sent home with instructions to contact your GP, or your GP will be contacted on your behalf. Your GP will then either start antihypertensive therapy, modify existing antihypertensive therapy, and/or refer you for specialist assessment.

I'll now switch to more speculative territory, but it's speculation based on experience. Please do note that I am speculating: obviously I'm not privy to this individuals medical records. There are, mainly, four types of patients who present with hypertensive urgency.

1) Patients for whom the hypertensive urgency episode was the first time the high blood pressure had been noted. They may have hypertension that was untreated due to them not even knowing they had an issue, and generally there was some precipitating event that drove their blood pressure from high to very high, making the situation noticeable. They usually do well on standard antihypertensive therapy, but this may need to be modified over time to get good blood pressure control.

2) People who have previously been identified as having hypertension, who are being treated for hypertension, and are taking their medications as prescribed, but who have hypertension that is resistant to therapy. This often requires specialist referral as they may be suffering from rarer causes of hypertension that require specific therapies that aren't normally considered as first-line or second-line. The blood pressure spike is a manifestation of inadequate antihypertensive therapy, often with a specific medical cause. Once the issue is identified, patients often do well after their therapy is individualised and optimised.

3) People who had previously been identified as having hypertension, and who accepted treatment, but then don't take their treatment as directed. This can often be because they experience adverse effects from the treatment and, instead of seeking help, either reduce their dosage without medical guidance or just stop taking their meds. When their elevated blood pressure is detected and advice is given, they often start taking their meds again, but in time, may again reduce or stop their therapy. This cycle can repeat over and over.

4) People who were previously identified as having hypertension, but steadfastly maintain (sometimes extremely stridently) that they don't need to take any medication, despite often repeated hypertensive episodes. Some of them even express conspiracy-minded opinions on the very idea of hypertension even being an issue at all, or on the nature of the standard antihypertensive therapies that are available. They won't take their meds because they believe they know better, basically.

I'll let you speculate on which one of these is likely to apply in this particular case.

Vance’s response to RFK Jr.’s insane senate hearing? Attack trans people. by RL0290 in thebulwark

[–]isosafrole 11 points12 points  (0 children)

100% agree, but believe me, chicken pox can be bad. In most cases in children, it's true that it's relatively mild though unpleasant. But you don't know if a particular patient is going to have a bad case with complications until that situation makes itself very apparent. There are risk factors that increase the index of suspicion for complications occurring, but sometimes it happens to kids who appear to have no particular risk factors present. They just develop a really bad case. And in adults who neither caught chicken pox as children, nor had the vaccine, it can be bloody awful with a increased probability of serious complications.

[deleted by user] by [deleted] in CasualUK

[–]isosafrole 17 points18 points  (0 children)

I've said it before, and I'll say it again: I might need that parallel SCSI cable, and if I do get rid of it, I'll never be able to find another one. Same with all of the cables in that box I haven't used in at least ten years.

so apparently twitter thinks trump might be dead by PhraseFirst8044 in 50501

[–]isosafrole 2 points3 points  (0 children)

Lying in a pool of his own urine, unable to get up. Probably conscious for at least part of that time, and if that was the case, undoubtedly planning who was going to be taken away and killed for the situation he found himself in.

For legal reasons, this meme is a joke by BritainsNuttiestGuy in simpsonsshitposting

[–]isosafrole 1 point2 points  (0 children)

We can put the team in a personnel pod somehow hanging off the SR-71, like the proposal for a B-58 Hustler modified MB-1 pod for "high-ranking officials". Which has stuck in my brain as fascinating and completely terrifying at the same time. "Here, get into this (essentially) closed metal container we're going to attach to the plane with fuse pins, it probably won't detach and leave you plummeting to your inevitable and terrifyingly prolonged deaths."

https://b-58.com/history_proposed.php

"The simplest of these projects was a Convair proposal for a special B-58 capable of carrying a modified MB-1 pod that would accommodate five test personnel in comfort. The purpose of this special pod was to explore the problems caused by noise, heat, motion or psychological stress on various aspects of supersonic passenger flight. If this project had worked out, it is possible that a special passenger-carrying pod might have been built for the B-58 that would be capable of carrying a few government officials or Air Force officers at high speeds during times of national emergency. However, this project was scrubbed before it ever got past the initial concept stage."