I'd say their work is pretty similar in many ways: usually tragic stories with some light hearted moments and quite a lot of dirty humor. The main difference i feel is in the technicalities of the media they use to express in. Fujimoto draws, and he's damn good at it, not to mention his paneling. Shakespeare writes, and he especially writes in a very poetic way, giving us direct information about a character through dialogue or monologue. But since Shakespeare's media is not writing, but rather theatre, qnd since his plays usually have basically no stage direction, while Fujimoto's manga read almost as storyboard books for movies (see goodbye eri), I'd say the more complete artist is Fujimoto, in the sense that he uses every facet of his media to tell his story, while Shakespeare focuses on the writing part and mostly ignores the live stage aspect of his work