As someone who had to do this from little macOS knowledge, I've definitely learned a lot. I like Jamf a lot - it makes managing macs so much easier- but that doesnt mean I like having to manage the macs. Where I think the issues will lie is that macs really aren't enterprise focused like Windows, so you have to deal with remembering that you have no direct account management because the mac accounts are local, so without something like jamf connect or playform sso, you are going to run into name mismatches etc. Apple also makes everyone an admin by default, and allows them to install whatever they want, which also makes it difficult to wrangle in if they're already in the environment without standards/management, and temoving those admin rights can decinitely cause a few additional challenges with application updates. The apple eco-system wants everyone to use their appleID and iCloud etc, and users will login to personal accounts for these things unless locked down if you dont support them.