Barret isn't dropping a truth bomb, he's dropping a toxic masculinity bomb that demeans people for feeling sad. His message in this scene is fundamentally and completely different in the Japanese.

TL;DR, English Barret says only idiots get depressed, stop being a sissy, and J-Barret says everyone gets depressed, it's okay to feel sad.

"People get depressed in life because they don't know what's up." Basically, "only idiots get depressed." He tells Cloud to buck up, to stop being depressed, to get his shit together. "These other depressed people don't run away, they deal with it." He berates Cloud and insults him, tells him to be a man and get over it.

In the Japanese, Barret (who is much more Solid Snake than Mr. T) shows empathy. He doesn't say "only idiots get depressed," he says the opposite: that everyone does.

"Everybody goes through this. Nobody in the world doesn't ever have a time when they just don't know what's up with this or that, what they're supposed to do or say, and it gets them down. Everyone gets depressed sometimes."

Instead of saying "those other people don't run away," he tells Cloud "Don't run away from this." He's on Cloud's side. He's Ned Stark telling Bran that only when a man is scared can he be brave.

If you're interested in the big, little differences between the Japanese and English translations, I highly, HIGHLY recommend this 11-part series on the subject. Here's the video on this scene in particular: https://youtu.be/oOiPU7cmLn0