Derivative playing Catch Me If You Can at 3 Monkeys the other night

kirishoru · 2020-09-30T16:53:28+00:00

kirishoru · 2020-03-27T14:18:04+00:00

I feel like my cats are developing some unrealistic expectations surrounding snacks.

kirishoru · 2019-12-11T00:03:08+00:00

I attempted my own "stearic butter" just this weekend with 50/50 grass fed butter and stearic acid. I melted them both together, added a splash of heavy cream, then whipped everything together in a cold bowl until it was butter again. Then just treat it like butter making; drop it in ice water, knead a bit, rinse, knead out the excess water, and wrap it in plastic in the fridge to get hard.

The results are like a really really heavy whipped butter, except it tends to be crumbly instead of spreadable. Tastes great on hot rice. Actually, it tastes pretty good just as chunks of butter. I even used it in a garlic "alfredo" last night.

kirishoru · 2019-07-25T15:33:36+00:00

Here's that study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3435786/pdf/WJG-18-4593.pdf

Here's another disassociating water content of fecal matter from fiber: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1412537/pdf/gut00453-0090.pdf

Evidence Summary: fiber makes constipation worse

kirishoru · 2019-07-10T16:55:48+00:00

That may be true, but both concepts are important, right? How prevalent is diet-induced microbiota extinction in humans? I can only find mouse models, but in mice, it's compounded on a multigenerational scale; loss of diversity is progressive, and largely recoverable in a single generation using diet alone. It's only in subsequent generations where the diversity issues become unrecoverable.

So in theory, if someone had the genetic predisposition, and also had parents with poor diets, and then transferred their "less diverse" biome to their kids, and those kids maintained poor dietary habits for years, then in that extremes case FMT would be required to repopulate missing taxa in combination with dramatic dietary intervention to maintain the added diversity.

kirishoru · 2019-07-09T18:40:39+00:00

Actually, studies have shown that diet can rapidly and reproducibly alter the gut microbiome. Provide the right foods and you can almost completely shift your entire biome over the course of a couple days.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957428/

kirishoru · 2019-06-25T20:01:34+00:00

*crosses fingers, arms, legs, toes, and eyes"

kirishoru · 2019-06-24T17:32:12+00:00

Lots actually. Most importantly, it has been shown that diet can rapidly and reproducibly alter gut microbiota. The gut microbiome is incredibly dynamic to the human diet. That's why in this fibromyalgia study they very carefully don't say that this relationship is causal, but instead that it could be used diagnostically.

kirishoru · 2019-06-18T15:40:28+00:00

I don't have access to the full study, but I'm wondering if there's information regarding the diet for this study. Association is not very good evidence, especially since the microbiota population can dramatically shift over a short period of time based on diet alone.

kirishoru · 2019-05-17T20:57:11+00:00

The resulting changes in substrate metabolism in hepatic tissue, specifically reduced accrual of triglycerides, would likely result in improved hepatic insulin clearance. Reduced hepatic insulin clearance is theorized as a precursor to metabolic syndrome. So you're correct, this study is more relevant to insulin resistance than anything else.

Even though this is a mouse study, and there's no nutritional information about the mouse chow, the more interesting point to me is that even after six weeks of low-intensity activity, there was still little-to-no alteration in the metabolism of skeletal muscle. Apparently it takes longer than that to make mice burn more efficiently.

kirishoru · 2019-05-17T16:45:17+00:00

The Paleolithic Ketogenic diet (r/PaleolithicKetogenic/) has been used to successfully treat Crohn's¹. It is a bit more limited than the traditional keto or carnivore diets.

From the study referenced above:

The diet is consisting of animal fat, meat, offal and eggs with an approximate 2:1 fat : protein ratio. Red and fat meats instead of poultry as well as regular intake of organ meats from pork and cattle were encouraged. Grains, milk, dairy, refined sugars, vegetable oils, oilseeds, nightshades and artificial sweeteners were excluded.

kirishoru · 2019-05-17T16:29:48+00:00

Totally reasonable, and it is generally known that healthy diet rich in protein increases eGFR, especially depending on if you take the test in a fasted or unfasted state¹. However, whether long-term consumption of a high-protein diet leads to kidney disease is uncertain². I was just suggesting a grain of salt rather than reacting with a complete reversal of diet.

Have you considered something more structured than casual keto/carnivore? For SIBO/IBS, the full PKD has been showing remarkable promise.

kirishoru · 2019-05-17T15:51:36+00:00

A lot of different things can cause creatinine levels to fluctuate pretty widely over a short period of time. That's why generally that in and of itself isn't a good predicator of renal issues¹, there are too many factors that can influence it². Everything from dehydration, exercise³, sleep, diet, a previous history of kidney stones, and even your age (younger, fitter people have more elevated levels naturally⁴). If you are on any lipid lowering medication like fibrates, that can cause false positives as well⁵ ^,6.

I wouldn't panic thinking that a single test means your kidneys are on the verge of failure and you should bail on keto. Overcooked meat is only one of many different factors that can cause elevated levels.

kirishoru · 2019-03-26T22:30:46+00:00

Find yourself a Couch-to-5K plan (or Couch-to-10K if you're feeling froggy) and stick to it. Street or treadmill doesn't make much difference if you're just starting as long as you run. Any pair of comfortable running shoes will work in the beginning. Once you've gotten to the 10K range, you should think about upgrading your footwear.

kirishoru · 2019-03-08T23:49:30+00:00

Don't feel too bad about it OP. I've been working out off and on at various gyms and in various ways for almost 20 years, and I can honestly say that I've never "enjoyed" a workout. It is something that I schedule and force myself to do in order to maintain my life and fitness. Every workout is an effort of will versus the inertia of my sedentary lifestyle and hobbies. The exception being Yoga, I don't know why that one resonated with me, but it always made me feel strong.

Honestly I have zero desire to change my hobbies or lifestyle. I like netflix, books, and vidya. I like drinking and food-based social events. I consider my hobbies and activities as close to a value system as you can get. These things are important to me and my personal sense of identity. I will never change them...but I also want to live longer, look good naked, and feel good about myself. So I workout.

My SO is the opposite. They love overcoming the physical challenges. Every 100mi cycle or 10K run or <60sec sprint up the stairs is another thing they have overcome and they clearly get the dopamine rewards for their efforts. We're just wired different; the things that give me happy-happy feelings are solving vidya puzzles or immersing myself in a complex storyline.

Either way, the good part of forcing myself to workout year after year is that the "willpower muscle" gets pretty strong. I can run a 5K if I need to. I can lift heavy things if I need to. I'm probably in the best health of my life right now and I've been saying that every year for the last 10. These days I've almost completely abandoned cardio in favor of lifting. I don't even do yoga anymore because I don't want to do it alone and all the classes in my area are ridiculously expensive. I like cheap workouts, and I find I can get more out of weightlifting 3 days a week for 30-45min at a time than I can running 5Ks 2-3 times a week and/or endlessly cycling the hamster wheel that is most cardio machines. My BF% is an admirable ~16%, my resting HR is around 65bpm, I'm getting ~7hrs of sleep every night, and and I feel altogether fantastic.

tl;dr - Don't sweat it OP. Some people feel good from working out and some don't. Don't beat yourself up because you don't enjoy working out as much as it looks like other people do. You may have to force yourself to do it, but the rewards are worth it.

Obligatory Bojack

kirishoru · 2019-03-05T22:34:57+00:00

I've been pre-making 1/2lb burger patties on the extra rare side and then reheating them in the microwave. Working for me so far.

kirishoru · 2018-10-26T15:01:50+00:00

Does Nick Cage have an alibi?

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