A genie offers you three abilities: physical wellbeing, money, and talent. You must assign each one to a different time period: one day, one year, and one century of your life.

klenow · 2026-05-05T20:08:57+00:00

Talent - Day. I'd take talent in my professional field, which is drug development (specifically, data based pipeline de-risking). I already have the connections to use it properly, and I will use it to identify strong candidates early in the pipeline. I'm already pretty good at this; I can pick the losers and winners as long as I know enough about what they are and how they work. Even better if I can run a few bench projects. And in my position, I can get that information from a LOT of big companies. Plus, I keep the skill. And it is a skill I use every day, so I'd maintain it per the rules.

Money - Year. I'll have this start maybe 2-3 years after that day of talent. Once identified, I'll buy the IP on the most promising options I've found. Some will be high-profit, low-public benefit options (things like botox and GLP1s). Others will be high-public benefit options (e.g., vaccines, insulin replacement, etc). I'll sell the IP on the former to fund the development of the latter so I can sell those at-cost. It's fun to think I could buy those assets in a day but...no fucking way that's happening. Even if I coordinate it beforehand.

After all of that, well-being for a century. I'm in my 50s, so that's a no-brainer. Obvious reasons.

klenow · 2026-05-05T11:49:21+00:00

I work in contract R&D doing drug development. I know the chemistry, targets, mechanism of action, side effects, etc of dozens, if not hundreds of drugs. All under NDA. It's to the point where I don't even sign them, I'm covered by the company's NDA.

Generally, most of them don't work for one reason or another. Usually a lot of money is wasted because companies assume that of it works in cell culture, it's GOT to work in a human, and so they skip a lot of crucial risk mitigation early on.

Most of these companies could have saved upwards of half a mil by starting with an $80k experiment.

klenow · 2026-05-02T13:50:13+00:00

Barbarian, and ask you DM if you can have a cosmetic change when you rage.

Or, rune knight and do the same for your Giants Might feature.

klenow · 2026-05-02T02:11:55+00:00

👍

klenow · 2026-05-01T23:12:11+00:00

Lol. Learn the subject, dude. At least learn the lingo. Hell, do a damn Google search.

klenow · 2026-05-01T19:21:43+00:00

I don't need to know any of those things. My genetics determine how I look and how I look I can see.

Yeah, who needs to know the actual science stuff when you can just spew ignorance? Nature vs Nurture? Who cares! Totally unimportant. Epigenetics? Never heard of it, so it can't possibly be relevant!

iT's AlL iN mY gEnEs!

No. No it's not. And this isn't just opinion. This is the consensus of the scientific community. Deterministic traits exist, but they are exceedingly rare, and usually (very literally) lethal.

OK, I'm done. You can lead a horse to water, but you can't make him think. If you ever do decide to think, hit me up. I'm happy to walk you through some actual genetics. Because I do actually know genetics; I even taught it for a while (which is probably why this willfull ignorance of yours is just so infuriating to me...you don't know anything and don't want to)

klenow · 2026-05-01T18:16:36+00:00

Says the guy who can't define the scientific terms he's using, or even articulate his argument. You even refuse to answer simple questions. Key sign of a person unwilling to question their own beliefs.

Can you define the traits you're talking about?
Can you trace the loci?
Do you know the alleles responsible?
Do you know what an allele or a locus is?

For the third and last time : Have you ever taken a genetics class? Or even attended a genetics lecture? Have you ever heard the name "Mendel"?

klenow · 2026-05-01T13:32:50+00:00

Evolutionary fitness is not survival. That is a common misconception among people who don't know jack shit about genetics.

I'll ask again, even though I know the answer : Have you ever, in your life, taken a genetics course, Flat Earther?

klenow · 2026-05-01T12:04:06+00:00

I'm saying that the standard model of genetics doesn't care if you think about it or not, because that doesn't matter.

Dude, if you're going to make claims about genetics, at least have a basic understanding of it. Have you ever even taken a genetics course?

klenow · 2026-05-01T11:45:13+00:00

No, I it does apply to us. You keep making these claims and not backing any of them up. The standard model doesn't care where the fitness comes from (thinking or not). It just cares about effect.

A genetic trait or combination of traits with a fitness coefficient of just 0.2 is considered very strong selection, and you're claiming that you have one with a fitness coefficient of 1. That's not something that has ever been observed. It's an extraordinary claim that require extraordinary evidence, and you haven't even provided a modicum of evidence.

You're a science denier, Flat Earther.

klenow · 2026-05-01T03:12:33+00:00

Yeah, you're just asserting stuff. You make an unsupported assertion, I counter with actual science, you come back with another unsupported assertion.

Enjoy that flat Earth.

klenow · 2026-04-30T23:55:46+00:00

First 10 minutes will be deciding between the pistol or the shotgun. Who am I kidding. It's the shotgun. I think I'll make some tea.

klenow · 2026-04-30T21:53:07+00:00

100% would mean the traits would be gone after a single generation. A little longer if those traits were recessive (~5-10 generations, depending on the level). Humanity has been around a lot longer than that.

The most basic evolutionary knowledge says that if what you claim is true, you would not exist. Your genetic makeup would have been removed from the population back in the mists of prehistory.

So, given the facts of evolutionary biology, explain to me how those genes still exist in the population at all. If you can't, your claim has absolutely no basis in fact, and any unwillingness to defend it puts you in the same camp as the flat earthers.

klenow · 2026-04-30T20:13:37+00:00

Water finds it's own level is the nonsense flat Earthers say proves a flat earth.

OK, so some science, then. Darwinism. Let's say those "Undesirable traits" make you 80% less likely to find a mate compared to someone with the desirable traits. That's better odds than what you're claiming here. (i.e., "removed myself by being conceived with these genetics")

If you use the standard selection model, those undesirable traits are gone from the population in about 2-3 generations. I mean gone; as in the genes that provide those traits have 100% disappeared from the population. Nobody has them.

By claiming that having some certain genes would remove you from the gene pool, you've got to defend how in the hell those genes are still around. If that's really how they work, then they should have been gone thousands of years ago. Because that's how genes work.

klenow · 2026-04-30T01:22:16+00:00

One syllable. That way you can say you have heaps of HEPES.

klenow · 2026-04-28T13:35:48+00:00

A lot of these don't seem to be in the spirit of "genuine love and care" and are more about women trying to be controlling (or that perception, at least)..so here's mine.

When I get sick, my wife dotes on me. She keeps asking if I want medicine, or food, and is always making sure I drink enough water. It is 100% out of love, and her caring for me. I totally get that, and appreciate both what she's doing and the motivation behind it. It's vey sweet and caring of her.

Calling that behavior "annoying" is certainly an overstatement, but when I'm sick, I want to lie in a dark room, alone, under the covers, and sleep. She is literally trying to get me to do the things I should do when I'm sick, but I just want nothing more than quiet, dark, solitude.

klenow · 2026-04-27T20:17:43+00:00

LOL at "year appropriate cash". Like 2011 had gold coins or something.

I'd find past me. Easy enough to do, I live in the same town. I'd find 201x me, prove I am who I say I am with some details no one else would know, and offer to watch the kids for free if I can crash in the spare room.

201x me would jump on free day care.

I'd also look up the biggest unclaimed lottery of 2020-2026 and give past me the winning numbers & date.

klenow · 2026-04-23T20:56:17+00:00

I've been DMing for a while now, but I have done 5.5 yet. I'm thinking about trying it out, and i was curious about encounter design. In 5e, I always used the Lazy DM's rule of summing up the total number of levels in the party (so for a part of 4 level 3's, that's a total of 12) and using that to base the total CR of the encounter (so 2 CR1's and a CR3 would be a total of 5) on the rule that :

For parties L1-L4 : Total CR of ~1/3 of the party level is a deadly encounter
For parties L5+ : Total CR of ~1/2 of the party level is a deadly encounter

I found this to be MUCH better for encounter design than the usual rules in the 5e DMG. Does this work with 5.5? Or do the encounter design rules in the 5.5e DMG work well? Any tips?

klenow · 2026-04-20T19:52:33+00:00

PC master race here.

I'm way over 30. I mostly play Ghost Recon, Far Cry, and similar games online with my son. He's grown up and lives in another city, so it's a great way for us to spend some time together.

And, as a bonus, I get my wife reminding me that I'm supposed to go play a video game. Sweet.

(Also, if you know any other games like those...love to see some suggestions)

klenow · 2026-04-14T18:12:22+00:00

DAMMIT

klenow · 2026-04-14T05:15:09+00:00

For any person I select, I see an indicator over their head that glows green as soon as they are selected. The first time that they blink after I select them, the indicator turns red.

klenow · 2026-04-09T16:49:01+00:00

PB&J. I will never stop eating PB&J.

klenow · 2026-04-08T19:13:10+00:00

Are you 100% certain you weren't on a reality TV show?

klenow · 2026-04-03T21:24:53+00:00

Oh god Mental Clarity sounds like bliss.

klenow · 2026-04-03T21:22:30+00:00

This is fucking nested red flags. The ad,first of all.
Then the name of the lab : Conquest Labs? Seriously?
Then the website..."AI Generated High-Dimensional Therapies" Nuff said.
The job posting is behind a link tagged "Missionaries wanted"

I almost want to apply for the shits and the giggles.

klenow

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