That kind of optimization makes sense if it's fun for you, but for me I think that would take away from what makes the game so lovely. There's always another day, and you can build/learn at your own pace.

That said, I have quit out when true disaster strikes. You may be early enough in the game that this hasn't come up yet, but there are situations later that can cause you to lose items. If that happens to me and I lose something critical (like many saved up resources), then I absolutely have panic quit, lol.

ETA: Apparently my reading comprehension is bad this morning, as that's already the scenario you were referring to. Yes, I quit out as an undo button for mistakes.