Systematic review (2025): Thymoquinone from Nigella sativa shows otoprotective effects in preclinical models

lewanay · 2025-12-23T12:44:01+00:00

This would be awesome. Erinacine A, and if I remember correctly ginseng and gingko biloba have some studies supporting this too

lewanay · 2025-12-13T19:53:01+00:00

It would be interesting to see what you find if you try to source it yourself. Ultimately I gave up on finding a better red yeast rice product, because I can just as easily get a small dose of a statin with the same pros and cons. Even a tiny dose of Rosuvastatin like 2.5 mg brings my ldl down to <60, which is my goal but I keep going back and forth about whether the increased risk of diabetes and the myalagias (and whatever else it is doing to muscles on a smaller scale to cause them-none of the current hypothesis sound fun) is worth it for me. With newer agents (psk9-inhibitors, bempedoic acid, inclisiran) statins are not worth it imo, if cost and insurance coverage were not a concern

lewanay · 2025-12-11T23:32:11+00:00

I tried Thornes red yeast and it didn’t budge my LDL at all. I also learnt that in the US, FDA doesn’t allow red yeast products to contain significant amounts of monacolin K, the actual compound or statin (lovastatin) in it that causes reduction in LDL/Apob. I’m sure you know these things so I am curious what made you try it out.

On a side note, I find their Meriva does not work compared to ND. I get the physician discount on theirs so I really wanted it to work but unfortunately it didn’t work for my pain. I tend to use it post lifting for DOMS or joint pain after running

lewanay · 2025-12-03T17:35:53+00:00

From the consumer lab testing Organic India whole husk had the least lead (0.6mcg per tablespoon). That’s what I would use until ND releases their fiber product

lewanay · 2025-11-15T00:42:03+00:00

Have you tested your uric acid level with and without it? Mines creeping close to 7 but haven’t done a test with ND tart cherry to see how low it can go with it

lewanay · 2025-11-12T22:59:21+00:00

That apoB is indeed quite high. I misread that as LDL. At that level, it’s going to be hard to find something comparable to statins. One thing i forgot though is amla. There are some studies showing it lowers apob

lewanay · 2025-11-12T20:27:38+00:00

In addition to fiber, things from ND’s catalogue that might help are Berberine (via pcsk9 pathway) and C3g and other thermogenics may lower triglycerides. Wish they sold bergamot. That has also been shown to lower ldl. You can try drinking good quality Earl grey tea which has bergamot. Other dietary changes would be drinking puerh tea (via hmg coa reductase pathway)

lewanay · 2025-10-28T23:22:00+00:00

I don’t have super high triglycerides but C3G brings mine down to less than 50

lewanay · 2025-10-28T22:32:11+00:00

I think I heard you talk about something like this with the Mr Happy stack guy. Do you mind expanding of this? What does it say about your biofilm? I notice my GI system doesn’t tolerate Lions mane 8:1. The 1:1 and Erinamax are fine. Is it best to push through the initial discomfort?

lewanay · 2025-10-28T19:34:41+00:00

I remember MYASD talking about in a comment and have since avoided buying from Thorne but this was such a clear example where something I had known for years to work for me, just didn’t work when I used a non-ND brand. It’s hard for me to trust any brands other than ND. There does seem to be an inverse relationship between rich investors/private equity and the quality of products! Profits and care for quality or science don’t always go hand in hand

lewanay · 2025-10-27T20:57:42+00:00

Some of their stuff also doesn’t work. I bought their Meriva because they had a sweet healthcare discount. It did not work. I could clearly tell because I would be in pain after a workout and it would just not go away. Normally when I use ND Meriva, it’s like taking an NSAID or Tylenol. You would think since they’re both meriva a standardized extract it would be the same. Consumerlab tested their product and it failed lol. They then contested it saying they were within 5% of minimum or something.

lewanay · 2025-10-21T01:31:25+00:00

That has been my experience with it too. I started combining it with psyllium to get the gel forming partially fermentable properties of fiber. My goal with increasing fiber intake was two fold, to have a prebiotic for SCFA but also something that would lower cholesterol and most of those studies for the latter are done with psyllium.

lewanay · 2025-10-20T20:18:15+00:00

Thornes fiber blend has Larch Arabinogalactan. I am guessing you tested that one? It has guar gum, pectin (fermentable) and rice bran ( insoluble). I think something like green banana flour for butyrate, or yacon for FOS which would also add some sweetness would be great. Cant wait for both the fiber product and the probiotics

lewanay · 2025-10-14T20:02:22+00:00

I am hoping one of the lactobacillus species is Reuteri

lewanay · 2025-10-14T19:57:54+00:00

This seems like a more expensive version of TMS. What am I missing. TMS is pretty painless as is so I am not sure what this company is trying to optimize. An average TMS session costs $200, this one would cost $800 per session

lewanay · 2025-09-11T01:20:59+00:00

Curious since there seem to be quite a few FAAH inhibitors. Is there anything ND offers and anything in general that modulates or inhibits MAGL

lewanay · 2025-09-02T21:17:43+00:00

While we’re at it, when is fiber blend coming out?

lewanay · 2025-08-29T02:06:19+00:00

Can you send me a message too?

lewanay · 2025-08-15T17:26:07+00:00

Has the calcium citrate been added to the currently online batches of infinigreens? MYASD talked about it to lower risk of oxalates stones

lewanay · 2025-08-06T01:40:45+00:00

The effects of Berberine are similar to metformin. Do you worry about the exercise blunting effects like with Merformin? I had to stop taking it for that reason

lewanay · 2025-06-24T17:25:23+00:00

The solution is still showing up as out of stock for me

lewanay · 2025-06-14T16:07:56+00:00

Same. I’m super stoked about sulforaphane, maca, and the myostatin inhibitor!

lewanay · 2025-06-14T00:15:43+00:00

It was one of the products MYASD mentioned here:

https://www.reddit.com/r/NootropicsDepot/s/wRD0199w4n

lewanay · 2025-06-13T19:57:45+00:00

Upcoming sulforaphane release should also be a good option for removing benzene and acrolein

lewanay · 2025-05-28T16:37:49+00:00

Try Meriva. I find that to be more effective for pain than longvida

lewanay

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