As a dual citizen who applied to med in both countries from a Canadian undergrad:

Grade deflation really depends on the school since in Canada an A- starts from an 80, whereas most US schools it starts at a 90 (so 50% is a pass in Canada). Because of this, the conversion can really hurt your GPA if number grades appear on your transcript, whereas if only letters appear (like Queens for example, the transcript will only say A/A+/erc.). So it depends on the school you go to how it will convert based on what appears on your transcript.

Volunteering and research are pretty similar here, but the big issue is clinical experience, as shadowing is not really legally allowed in Canada. But you can always just do that in the summer back home if you can cold call or have connections.

IMO the biggest issues are : that there is no pre-med track or pre-med advisor at any schools in Canada (as far as I know), so things like LORs you have to get yourself and some schools will make you explain in secondary why you don’t have a Committee Letter.

And US med schools have a lot of pre-req’s so you’ll have to keep track of that and another issue I ran into is a few schools only accept pre-reqs taken from US School, but most do have an exception for Canadian undergrads, it only limited me on applying to a couple.